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MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 [ Homo sapiens (human) ]

Gene ID: 11183, updated on 3-May-2020

Summary

Official Symbol
MAP4K5provided by HGNC
Official Full Name
mitogen-activated protein kinase kinase kinase kinase 5provided by HGNC
Primary source
HGNC:HGNC:6867
See related
Ensembl:ENSG00000012983 MIM:604923
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KHS; GCKR; KHS1; MAPKKKK5
Summary
This gene encodes a member of the serine/threonine protein kinase family, that is highly similar to yeast SPS1/STE20 kinase. Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast pheromone response. This kinase was shown to activate Jun kinase in mammalian cells, which suggested a role in stress response. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in endometrium (RPKM 13.1), ovary (RPKM 10.3) and 25 other tissues See more
Orthologs

Genomic context

See MAP4K5 in Genome Data Viewer
Location:
14q22.1
Exon count:
37
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (50418475..50561126, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (50885211..50999376, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene L-2-hydroxyglutarate dehydrogenase Neighboring gene microRNA 4504 Neighboring gene distal membrane arm assembly complex 2 like Neighboring gene cyclin dependent kinase like 1 Neighboring gene zinc finger protein 678 pseudogene Neighboring gene atlastin GTPase 1 Neighboring gene small nuclear ribonucleoprotein polypeptide G pseudogene 1 Neighboring gene RNA, 7SL, cytoplasmic 452, pseudogene Neighboring gene salvador family WW domain containing protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Common genetic variation and performance on standardized cognitive tests.
NHGRI GWA Catalog
Genome-wide association study of periodontal health measured by probing depth in adults ages 18-49 years.
NHGRI GWA Catalog
Lupus nephritis susceptibility Loci in women with systemic lupus erythematosus.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
MAP kinase kinase kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
activation of JUN kinase activity TAS
Traceable Author Statement
more info
PubMed 
activation of MAPKKK activity IEA
Inferred from Electronic Annotation
more info
 
activation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction by protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
stress-activated protein kinase signaling cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
mitogen-activated protein kinase kinase kinase kinase 5
Names
MAPK/ERK kinase kinase kinase 5
MEK kinase kinase 5
MEKKK 5
germinal center kinase-related
kinase homologous to SPS1/STE20
NP_006566.2
NP_942089.1
XP_006720076.1
XP_011534679.1
XP_011534680.1
XP_011534681.1
XP_011534682.1
XP_024305229.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006575.5NP_006566.2  mitogen-activated protein kinase kinase kinase kinase 5

    See identical proteins and their annotated locations for NP_006566.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 2. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AK124738, AL118556, BC036013, CN343360
    UniProtKB/Swiss-Prot
    Q9Y4K4
    UniProtKB/TrEMBL
    B3KWC4
    Conserved Domains (2) summary
    smart00036
    Location:511826
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06646
    Location:10277
    STKc_MAP4K5; Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase kinase kinase 5
  2. NM_198794.3NP_942089.1  mitogen-activated protein kinase kinase kinase kinase 5

    See identical proteins and their annotated locations for NP_942089.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AK124738, AL118556, BC036013, CB990293
    UniProtKB/Swiss-Prot
    Q9Y4K4
    UniProtKB/TrEMBL
    B3KWC4
    Conserved Domains (2) summary
    smart00036
    Location:511826
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06646
    Location:10277
    STKc_MAP4K5; Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase kinase kinase 5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    50418475..50561126 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536378.3XP_011534680.1  mitogen-activated protein kinase kinase kinase kinase 5 isoform X3

    Conserved Domains (3) summary
    smart00036
    Location:444759
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:3210
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06613
    Location:1210
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
  2. XM_024449461.1XP_024305229.1  mitogen-activated protein kinase kinase kinase kinase 5 isoform X1

    Conserved Domains (2) summary
    smart00036
    Location:511826
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06646
    Location:10277
    STKc_MAP4K5; Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase kinase kinase 5
  3. XM_006720013.4XP_006720076.1  mitogen-activated protein kinase kinase kinase kinase 5 isoform X1

    See identical proteins and their annotated locations for XP_006720076.1

    UniProtKB/Swiss-Prot
    Q9Y4K4
    Conserved Domains (2) summary
    smart00036
    Location:511826
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06646
    Location:10277
    STKc_MAP4K5; Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase kinase kinase 5
  4. XM_011536377.3XP_011534679.1  mitogen-activated protein kinase kinase kinase kinase 5 isoform X2

    See identical proteins and their annotated locations for XP_011534679.1

    Related
    ENSP00000013125.4, ENST00000013125.8
    Conserved Domains (3) summary
    smart00036
    Location:511825
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:20277
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06646
    Location:10277
    STKc_MAP4K5; Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase kinase kinase 5
  5. XM_011536379.3XP_011534681.1  mitogen-activated protein kinase kinase kinase kinase 5 isoform X4

    Conserved Domains (3) summary
    smart00036
    Location:375690
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:1141
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:1141
    PKc_like; Protein Kinases, catalytic domain
  6. XM_011536380.3XP_011534682.1  mitogen-activated protein kinase kinase kinase kinase 5 isoform X5

    Conserved Domains (1) summary
    smart00036
    Location:222537
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
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