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KAT7 lysine acetyltransferase 7 [ Homo sapiens (human) ]

Gene ID: 11143, updated on 22-Aug-2021

Summary

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Official Symbol
KAT7provided by HGNC
Official Full Name
lysine acetyltransferase 7provided by HGNC
Primary source
HGNC:HGNC:17016
See related
Ensembl:ENSG00000136504 MIM:609880
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HBO1; HBOA; MYST2; ZC2HC7
Summary
The protein encoded by this gene is part of the multimeric HBO1 complex, which possesses histone H4-specific acetyltransferase activity. This activity is required for functional replication origins and is involved in transcriptional activation of some genes. In both cases, the acetylation of histone H4 helps unfold chromatin so that the DNA can be accessed and replicated or transcribed. [provided by RefSeq, Oct 2016]
Expression
Broad expression in testis (RPKM 37.1), bone marrow (RPKM 22.8) and 24 other tissues See more
Orthologs
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Genomic context

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See KAT7 in Genome Data Viewer
Location:
17q21.33
Exon count:
16
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (49788681..49835026)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (47866043..47912388)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 35 member B1 Neighboring gene family with sequence similarity 117 member A Neighboring gene signal recognition particle 14 pseudogene 3 Neighboring gene uncharacterized LOC729220 Neighboring gene tachykinin precursor 4 Neighboring gene CRISPRi-validated cis-regulatory element chr17.3537

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The histone acetyltransferase HBO1 functions as a novel oncogenic gene in osteosarcoma. Gao YY, et al. Theranostics, 2021. PMID 33754016, Free PMC Article
  2. CircMRPS35 suppresses gastric cancer progression via recruiting KAT7 to govern histone modification. Jie M, et al. Mol Cancer, 2020 Mar 12. PMID 32164722, Free PMC Article
  3. HBO1 (KAT7) Does Not Have an Essential Role in Cell Proliferation, DNA Replication, or Histone 4 Acetylation in Human Cells. Kueh AJ, et al. Mol Cell Biol, 2020 Jan 30. PMID 31767635, Free PMC Article
  4. Deciphering structure, function and mechanism of lysine acetyltransferase HBO1 in protein acetylation, transcription regulation, DNA replication and its oncogenic properties in cancer. Lan R, et al. Cell Mol Life Sci, 2020 Feb. PMID 31535175
  5. HBO1 directs histone H4 specific acetylation, potentiating mechano-transduction pathways and membrane elasticity in ovarian cancer cells. Quintela M, et al. Nanomedicine, 2019 Apr. PMID 30759370

See all (107) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The histone acetyltransferase HBO1 functions as a novel oncogenic gene in osteosarcoma.
    Title: The histone acetyltransferase HBO1 functions as a novel oncogenic gene in osteosarcoma.
  2. KAT7 is a genetic vulnerability of acute myeloid leukemias driven by MLL rearrangements.
    Title: KAT7 is a genetic vulnerability of acute myeloid leukemias driven by MLL rearrangements.
  3. The Protective Effect of HBO1 on Cigarette Smoke Extract-Induced Apoptosis in Airway Epithelial Cells.
    Title: The Protective Effect of HBO1 on Cigarette Smoke Extract-Induced Apoptosis in Airway Epithelial Cells.
  4. CircMRPS35 suppresses gastric cancer progression via recruiting KAT7 to govern histone modification.
    Title: CircMRPS35 suppresses gastric cancer progression via recruiting KAT7 to govern histone modification.
  5. UHRF1-KAT7-mediated regulation of TUSC3 expression via histone methylation/acetylation is critical for the proliferation of colon cancer cells.
    Title: UHRF1-KAT7-mediated regulation of TUSC3 expression via histone methylation/acetylation is critical for the proliferation of colon cancer cells.
  6. HBO1 is essential for H3K14 acetylation but HBO1 is dispensable for DNA replication and cell proliferation in immortalized human cells. HBO1 gene deletion led to profound changes in cell adhesion, particularly in 293T cells.
    Title: HBO1 (KAT7) Does Not Have an Essential Role in Cell Proliferation, DNA Replication, or Histone 4 Acetylation in Human Cells.
  7. identify the MYST acetyltransferase HBO1 (also known as KAT7 or MYST2) and several known members of the HBO1 protein complex as critical regulators of leukaemia stem cells maintenance
    Title: HBO1 is required for the maintenance of leukaemia stem cells.
  8. As the core catalytic subunit, HBO1 consists of an N-terminal domain and a C-terminal MYST domain that are in charge of acetyl-CoA binding and acetylation reaction. This paper reviews the recent advances and discusses the understanding of the multiple functions, activity regulation, and disease relationship of HBO1. [review]
    Title: Deciphering structure, function and mechanism of lysine acetyltransferase HBO1 in protein acetylation, transcription regulation, DNA replication and its oncogenic properties in cancer.
  9. These data suggest that LYAR promotes the association of the BRD2-KAT7 and BRD4-KAT7 complexes with transcription-competent rDNA loci but not to transcriptionally silent rDNA loci, thereby increasing rRNA synthesis by altering the local acetylation status of histone H3 and H4.
    Title: LYAR potentiates rRNA synthesis by recruiting BRD2/4 and the MYST-type acetyltransferase KAT7 to rDNA.
  10. HBO1 preferentially acetylates histone H4 through the concomitant overexpression of co-regulator JADE2, and is required for the expression of YAP1, an ovarian cancer oncogene and mechano-transductor signaling factor.
    Title: HBO1 directs histone H4 specific acetylation, potentiating mechano-transduction pathways and membrane elasticity in ovarian cancer cells.
Submit: New GeneRIF Correction See all GeneRIFs (48)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
integrase gag-pol Cellular acetyltransferase binds HIV-1 integrase both in vitro and in cells and acetylates three specific lysine's (K264, K266, K273) in the carboxy-terminus of integrase PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA replication origin binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables histone acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables histone acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in histone H3 acetylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in histone H3-K14 acetylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in histone H4 acetylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in histone H4-K12 acetylation IDA
Inferred from Direct Assay
more info
 PubMed 
NOT involved_in histone H4-K16 acetylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in histone H4-K5 acetylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in histone H4-K8 acetylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in internal peptidyl-lysine acetylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in natural killer cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in positive regulation of DNA replication IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription, elongation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of erythrocyte differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of hematopoietic stem cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of histone H4 acetylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein localization to nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-dependent DNA replication initiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of nucleotide-excision repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription, DNA-templated TAS
Traceable Author Statement
more info
 PubMed 
involved_in response to actinomycin D IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to anisomycin IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to dithiothreitol IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to hydroxyurea IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to sorbitol IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in stress-activated protein kinase signaling cascade IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
part_of histone H3-K14 acetyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
NOT located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in site of DNA damage IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
histone acetyltransferase KAT7
Names
K(lysine) acetyltransferase 7
MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2
MYST histone acetyltransferase 2
histone acetyltransferase MYST2
histone acetyltransferase binding to ORC1
NP_001186084.1
NP_001186085.1
NP_001186086.1
NP_001186087.1
NP_001333635.1
NP_008998.1
XP_011522537.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051976.1 RefSeqGene

    Range
    5001..45478
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001199155.2 → NP_001186084.1  histone acetyltransferase KAT7 isoform 2

    See identical proteins and their annotated locations for NP_001186084.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC015795, AC027801
    Consensus CDS
    CCDS56035.1
    UniProtKB/Swiss-Prot
    O95251
    Related
    ENSP00000398961.2, ENST00000424009.6
    Conserved Domains (3) summary
    PLN00104
    Location:294 → 579
    PLN00104; MYST -like histone acetyltransferase; Provisional
    cd16378
    Location:209 → 262
    CcmH_N; N-terminal domain of cytochrome c-type biogenesis protein CcmH and related proteins
    pfam01530
    Location:184 → 212
    zf-C2HC; Zinc finger, C2HC type

  2. NM_001199156.2 → NP_001186085.1  histone acetyltransferase KAT7 isoform 3

    See identical proteins and their annotated locations for NP_001186085.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC015795, AC027801
    Consensus CDS
    CCDS56037.1
    UniProtKB/Swiss-Prot
    O95251
    Related
    ENSP00000413415.2, ENST00000454930.6
    Conserved Domains (2) summary
    pfam01530
    Location:53 → 73
    zf-C2HC; Zinc finger, C2HC type
    cl27485
    Location:185 → 470
    MOZ_SAS; MOZ/SAS family

  3. NM_001199157.2 → NP_001186086.1  histone acetyltransferase KAT7 isoform 4

    See identical proteins and their annotated locations for NP_001186086.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC015795, AC027801
    Consensus CDS
    CCDS56036.1
    UniProtKB/Swiss-Prot
    O95251
    Related
    ENSP00000424577.1, ENST00000509773.5
    Conserved Domains (2) summary
    pfam01530
    Location:113 → 132
    zf-C2HC; Zinc finger, C2HC type
    cl27485
    Location:214 → 499
    MOZ_SAS; MOZ/SAS family

  4. NM_001199158.2 → NP_001186087.1  histone acetyltransferase KAT7 isoform 5

    See identical proteins and their annotated locations for NP_001186087.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks three alternate in-frame exons compared to variant 1. The resulting isoform (5) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC015795, AC027801
    Consensus CDS
    CCDS56038.1
    UniProtKB/Swiss-Prot
    O95251
    Related
    ENSP00000423385.1, ENST00000510819.5
    Conserved Domains (3) summary
    pfam01530
    Location:53 → 73
    zf-C2HC; Zinc finger, C2HC type
    cl01179
    Location:70 → 123
    CcmH_N; N-terminal domain of cytochrome c-type biogenesis protein CcmH and related proteins
    cl27485
    Location:155 → 440
    MOZ_SAS; MOZ/SAS family

  5. NM_001346706.2 → NP_001333635.1  histone acetyltransferase KAT7 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (6) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC015795, AC027801
    Conserved Domains (2) summary
    pfam01530
    Location:113 → 132
    zf-C2HC; Zinc finger, C2HC type
    cl27485
    Location:244 → 529
    MOZ_SAS; MOZ/SAS family

  6. NM_007067.5 → NP_008998.1  histone acetyltransferase KAT7 isoform 1

    See identical proteins and their annotated locations for NP_008998.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC015795, AC027801
    Consensus CDS
    CCDS11554.1
    UniProtKB/Swiss-Prot
    O95251
    Related
    ENSP00000259021.4, ENST00000259021.9
    Conserved Domains (2) summary
    PLN00104
    Location:324 → 609
    PLN00104; MYST -like histone acetyltransferase; Provisional
    pfam01530
    Location:184 → 212
    zf-C2HC; Zinc finger, C2HC type

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    49788681..49835026
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011524235.3 → XP_011522537.1  histone acetyltransferase KAT7 isoform X1

    See identical proteins and their annotated locations for XP_011522537.1

    Conserved Domains (2) summary
    pfam01853
    Location:110 → 288
    MOZ_SAS; MOZ/SAS family
    cl17182
    Location:54 → 306
    NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O95251.1 GenPept UniProtKB/Swiss-Prot:O95251

Gene LinkOut

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