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KAT7 lysine acetyltransferase 7 [ Homo sapiens (human) ]

Gene ID: 11143, updated on 2-Oct-2018

Summary

Official Symbol
KAT7provided by HGNC
Official Full Name
lysine acetyltransferase 7provided by HGNC
Primary source
HGNC:HGNC:17016
See related
Ensembl:ENSG00000136504 MIM:609880; Vega:OTTHUMG00000161770
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HBO1; HBOA; MYST2; ZC2HC7
Summary
The protein encoded by this gene is part of the multimeric HBO1 complex, which possesses histone H4-specific acetyltransferase activity. This activity is required for functional replication origins and is involved in transcriptional activation of some genes. In both cases, the acetylation of histone H4 helps unfold chromatin so that the DNA can be accessed and replicated or transcribed. [provided by RefSeq, Oct 2016]
Expression
Broad expression in testis (RPKM 37.1), bone marrow (RPKM 22.8) and 24 other tissues See more
Orthologs

Genomic context

See KAT7 in Genome Data Viewer
Location:
17q21.33
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (49788619..49829096)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (47865922..47906458)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 35 member B1 Neighboring gene family with sequence similarity 117 member A Neighboring gene uncharacterized LOC729220 Neighboring gene tachykinin 4 Neighboring gene MRT4 homolog, ribosome maturation factor pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
integrase gag-pol Cellular acetyltransferase binds HIV-1 integrase both in vitro and in cells and acetylates three specific lysine's (K264, K266, K273) in the carboxy-terminus of integrase PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Androgen receptor signaling pathway, organism-specific biosystem (from WikiPathways)
    Androgen receptor signaling pathway, organism-specific biosystemAndrogens, mainly testosterone and 5alpha-dihydrotestosterone (DHT) play significant role in the growth and development of the male reproductive organs. These steroid hormones bring about their biolo...
  • Chromatin modifying enzymes, organism-specific biosystem (from REACTOME)
    Chromatin modifying enzymes, organism-specific biosystemEukaryotic DNA is associated with histone proteins and organized into a complex nucleoprotein structure called chromatin. This structure decreases the accessibility of DNA but also helps to protect i...
  • Chromatin organization, organism-specific biosystem (from REACTOME)
    Chromatin organization, organism-specific biosystemChromatin organization refers to the composition and conformation of complexes between DNA, protein and RNA. It is determined by processes that result in the specification, formation or maintenance o...
  • HATs acetylate histones, organism-specific biosystem (from REACTOME)
    HATs acetylate histones, organism-specific biosystemHistone acetyltransferases (HATs) involved in histone modifications are referred to as A-type or nuclear HATs. They can be grouped into at least four families based on sequence conservation within th...
  • Regulation of Androgen receptor activity, organism-specific biosystem (from Pathway Interaction Database)
    Regulation of Androgen receptor activity, organism-specific biosystem
    Regulation of Androgen receptor activity

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA replication origin binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
H4 histone acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription regulatory region DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA replication IDA
Inferred from Direct Assay
more info
PubMed 
histone H3 acetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone H3 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
histone H4-K12 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
NOT histone H4-K16 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
histone H4-K5 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
histone H4-K8 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of histone H4 acetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein localization to nucleus IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated TAS
Traceable Author Statement
more info
PubMed 
response to actinomycin D IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to anisomycin IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to dithiothreitol IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to hydroxyurea IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to sorbitol IMP
Inferred from Mutant Phenotype
more info
PubMed 
stress-activated protein kinase signaling cascade IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
nuclear chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
histone acetyltransferase KAT7
Names
K(lysine) acetyltransferase 7
MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2
MYST histone acetyltransferase 2
histone acetyltransferase MYST2
histone acetyltransferase binding to ORC1
NP_001186084.1
NP_001186085.1
NP_001186086.1
NP_001186087.1
NP_001333635.1
NP_008998.1
XP_011522537.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051976.1 RefSeqGene

    Range
    5001..45478
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001199155.1NP_001186084.1  histone acetyltransferase KAT7 isoform 2

    See identical proteins and their annotated locations for NP_001186084.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC015795, AF217502, AK294836, DC306552
    Consensus CDS
    CCDS56035.1
    UniProtKB/Swiss-Prot
    O95251
    Related
    ENSP00000398961.2, OTTHUMP00000220717, ENST00000424009.6, OTTHUMT00000366037
    Conserved Domains (2) summary
    pfam01530
    Location:184212
    zf-C2HC; Zinc finger, C2HC type
    cl27485
    Location:294579
    MOZ_SAS; MOZ/SAS family
  2. NM_001199156.1NP_001186085.1  histone acetyltransferase KAT7 isoform 3

    See identical proteins and their annotated locations for NP_001186085.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC015795, AF217502, AK293976, DC306552
    Consensus CDS
    CCDS56037.1
    UniProtKB/Swiss-Prot
    O95251
    Related
    ENSP00000413415.2, OTTHUMP00000220714, ENST00000454930.6, OTTHUMT00000366033
    Conserved Domains (2) summary
    pfam01530
    Location:5373
    zf-C2HC; Zinc finger, C2HC type
    cl27485
    Location:185470
    MOZ_SAS; MOZ/SAS family
  3. NM_001199157.1NP_001186086.1  histone acetyltransferase KAT7 isoform 4

    See identical proteins and their annotated locations for NP_001186086.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AF217502, AK294014, DC306552
    Consensus CDS
    CCDS56036.1
    UniProtKB/Swiss-Prot
    O95251
    Related
    ENSP00000424577.1, OTTHUMP00000220715, ENST00000509773.5, OTTHUMT00000366034
    Conserved Domains (2) summary
    pfam01530
    Location:113132
    zf-C2HC; Zinc finger, C2HC type
    cl27485
    Location:214499
    MOZ_SAS; MOZ/SAS family
  4. NM_001199158.1NP_001186087.1  histone acetyltransferase KAT7 isoform 5

    See identical proteins and their annotated locations for NP_001186087.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks three alternate in-frame exons compared to variant 1. The resulting isoform (5) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AF217502, AK294052, DC306552
    Consensus CDS
    CCDS56038.1
    UniProtKB/Swiss-Prot
    O95251
    Related
    ENSP00000423385.1, OTTHUMP00000220716, ENST00000510819.5, OTTHUMT00000366035
    Conserved Domains (3) summary
    pfam01530
    Location:5373
    zf-C2HC; Zinc finger, C2HC type
    cl01179
    Location:70123
    CcmH_N; N-terminal domain of cytochrome c-type biogenesis protein CcmH and related proteins
    cl27485
    Location:155440
    MOZ_SAS; MOZ/SAS family
  5. NM_001346706.1NP_001333635.1  histone acetyltransferase KAT7 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (6) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC015795, AC027801, AW889189
    Conserved Domains (2) summary
    pfam01530
    Location:113132
    zf-C2HC; Zinc finger, C2HC type
    cl27485
    Location:244529
    MOZ_SAS; MOZ/SAS family
  6. NM_007067.4NP_008998.1  histone acetyltransferase KAT7 isoform 1

    See identical proteins and their annotated locations for NP_008998.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AF217502, DC306552
    Consensus CDS
    CCDS11554.1
    UniProtKB/Swiss-Prot
    O95251
    Related
    ENSP00000259021.4, OTTHUMP00000220713, ENST00000259021.8, OTTHUMT00000366032
    Conserved Domains (2) summary
    pfam01530
    Location:184212
    zf-C2HC; Zinc finger, C2HC type
    cl27485
    Location:324609
    MOZ_SAS; MOZ/SAS family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    49788619..49829096
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011524235.3XP_011522537.1  histone acetyltransferase KAT7 isoform X1

    See identical proteins and their annotated locations for XP_011522537.1

    Conserved Domains (2) summary
    pfam01853
    Location:110288
    MOZ_SAS; MOZ/SAS family
    cl17182
    Location:54306
    NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate
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