Format

Send to:

Choose Destination

KATNA1 katanin catalytic subunit A1 [ Homo sapiens (human) ]

Gene ID: 11104, updated on 10-Oct-2019

Summary

Official Symbol
KATNA1provided by HGNC
Official Full Name
katanin catalytic subunit A1provided by HGNC
Primary source
HGNC:HGNC:6216
See related
Ensembl:ENSG00000186625 MIM:606696
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. This gene encodes the p80 subunit. This protein is a member of the AAA family of ATPases. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Feb 2011]
Expression
Broad expression in testis (RPKM 18.8), ovary (RPKM 7.2) and 24 other tissues See more
Orthologs

Genomic context

See KATNA1 in Genome Data Viewer
Location:
6q25.1
Exon count:
14
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (149594873..149649018, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (149916009..149970154, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene glycoprotein integral membrane 1 Neighboring gene ribosomal protein S18 pseudogene 9 Neighboring gene large tumor suppressor kinase 1 Neighboring gene uncharacterized LOC105378050 Neighboring gene uncharacterized LOC645967

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
isomerase activity IEA
Inferred from Electronic Annotation
more info
 
microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
microtubule-severing ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule-severing ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic microtubule organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule severing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
centrosome IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
microtubule IEA
Inferred from Electronic Annotation
more info
 
midbody IDA
Inferred from Direct Assay
more info
PubMed 
mitotic spindle pole IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spindle IDA
Inferred from Direct Assay
more info
PubMed 
spindle pole IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
katanin p60 ATPase-containing subunit A1
Names
katanin p60 (ATPase containing) subunit A 1
katanin p60 subunit A1
p60 katanin
NP_001191005.1
NP_008975.1
XP_005266861.1
XP_005266862.1
XP_016865696.1
XP_016865697.1
XP_016865698.1
XP_016865699.1
XP_024302085.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204076.1NP_001191005.1  katanin p60 ATPase-containing subunit A1 isoform 2

    See identical proteins and their annotated locations for NP_001191005.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two alternate in-frame exons in the central coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    BC050428, DB031858
    Consensus CDS
    CCDS56456.1
    UniProtKB/Swiss-Prot
    O75449
    Related
    ENSP00000335180.8, ENST00000335643.12
    Conserved Domains (1) summary
    pfam00004
    Location:169305
    AAA; ATPase family associated with various cellular activities (AAA)
  2. NM_007044.4NP_008975.1  katanin p60 ATPase-containing subunit A1 isoform 1

    See identical proteins and their annotated locations for NP_008975.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK292090, BC050428, CA426364
    Consensus CDS
    CCDS5217.1
    UniProtKB/Swiss-Prot
    O75449
    UniProtKB/TrEMBL
    A8K7S5
    Related
    ENSP00000356381.2, ENST00000367411.7
    Conserved Domains (3) summary
    smart00382
    Location:241382
    AAA; ATPases associated with a variety of cellular activities
    pfam00004
    Location:245381
    AAA; ATPase family associated with various cellular activities (AAA)
    pfam09336
    Location:456489
    Vps4_C; Vps4 C terminal oligomerization domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    149594873..149649018 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010209.1XP_016865698.1  katanin p60 ATPase-containing subunit A1 isoform X3

    Conserved Domains (1) summary
    COG0464
    Location:81356
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
  2. XM_005266805.4XP_005266862.1  katanin p60 ATPase-containing subunit A1 isoform X2

    Conserved Domains (2) summary
    pfam00004
    Location:226328
    AAA; ATPase family associated with various cellular activities (AAA)
    pfam09336
    Location:403436
    Vps4_C; Vps4 C terminal oligomerization domain
  3. XM_017010208.1XP_016865697.1  katanin p60 ATPase-containing subunit A1 isoform X3

    Conserved Domains (1) summary
    COG0464
    Location:81356
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
  4. XM_024446317.1XP_024302085.1  katanin p60 ATPase-containing subunit A1 isoform X3

    Conserved Domains (1) summary
    COG0464
    Location:81356
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
  5. XM_005266804.2XP_005266861.1  katanin p60 ATPase-containing subunit A1 isoform X1

    See identical proteins and their annotated locations for XP_005266861.1

    UniProtKB/Swiss-Prot
    O75449
    Related
    ENSP00000335106.5, ENST00000335647.9
    Conserved Domains (3) summary
    smart00382
    Location:241382
    AAA; ATPases associated with a variety of cellular activities
    pfam00004
    Location:245381
    AAA; ATPase family associated with various cellular activities (AAA)
    pfam09336
    Location:456489
    Vps4_C; Vps4 C terminal oligomerization domain
  6. XM_017010207.2XP_016865696.1  katanin p60 ATPase-containing subunit A1 isoform X1

    UniProtKB/Swiss-Prot
    O75449
    Conserved Domains (3) summary
    smart00382
    Location:241382
    AAA; ATPases associated with a variety of cellular activities
    pfam00004
    Location:245381
    AAA; ATPase family associated with various cellular activities (AAA)
    pfam09336
    Location:456489
    Vps4_C; Vps4 C terminal oligomerization domain
  7. XM_017010210.2XP_016865699.1  katanin p60 ATPase-containing subunit A1 isoform X1

    UniProtKB/Swiss-Prot
    O75449
    Conserved Domains (3) summary
    smart00382
    Location:241382
    AAA; ATPases associated with a variety of cellular activities
    pfam00004
    Location:245381
    AAA; ATPase family associated with various cellular activities (AAA)
    pfam09336
    Location:456489
    Vps4_C; Vps4 C terminal oligomerization domain
Support Center