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Katna1 katanin p60 (ATPase-containing) subunit A1 [ Mus musculus (house mouse) ]

Gene ID: 23924, updated on 6-Jun-2024

Summary

Official Symbol
Katna1provided by MGI
Official Full Name
katanin p60 (ATPase-containing) subunit A1provided by MGI
Primary source
MGI:MGI:1344353
See related
Ensembl:ENSMUSG00000019794 AllianceGenome:MGI:1344353
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables ATP hydrolysis activity and dynein complex binding activity. Acts upstream of or within microtubule cytoskeleton organization; neuron migration; and protein localization. Located in several cellular components, including axon; centrosome; and lipid droplet. Orthologous to human KATNA1 (katanin catalytic subunit A1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 6.5), placenta adult (RPKM 5.6) and 27 other tissues See more
Orthologs
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Genomic context

See Katna1 in Genome Data Viewer
Location:
10 A1; 10 2.32 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (7601748..7638913)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (7725990..7763150)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene protein-L-isoaspartate (D-aspartate) O-methyltransferase 1 Neighboring gene STARR-positive B cell enhancer ABC_E3875 Neighboring gene nucleoporin 43 Neighboring gene large tumor suppressor Neighboring gene STARR-seq mESC enhancer starr_25689 Neighboring gene STARR-positive B cell enhancer ABC_E6817 Neighboring gene STARR-positive B cell enhancer ABC_E9338 Neighboring gene glycoprotein integral membrane 1 Neighboring gene STARR-positive B cell enhancer mm9_chr10:7529819-7530120 Neighboring gene peptidylprolyl isomerase (cyclophilin)-like 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
PubMed 
enables dynein complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
 
enables microtubule severing ATPase activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in growth cone ISO
Inferred from Sequence Orthology
more info
 
part_of katanin complex ISO
Inferred from Sequence Orthology
more info
 
located_in lipid droplet IDA
Inferred from Direct Assay
more info
PubMed 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 
located_in mitotic spindle pole ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in spindle ISO
Inferred from Sequence Orthology
more info
 
located_in spindle pole ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
katanin p60 ATPase-containing subunit A1
Names
katanin p60 subunit A1
lipotransin
p60 katanin
NP_035965.3
XP_030100951.1
XP_036011678.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011835.3NP_035965.3  katanin p60 ATPase-containing subunit A1

    Status: VALIDATED

    Source sequence(s)
    AC156391
    Consensus CDS
    CCDS23689.2
    UniProtKB/Swiss-Prot
    Q9WV86
    UniProtKB/TrEMBL
    E9QKG2
    Related
    ENSMUSP00000019929.7, ENSMUST00000019929.13

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    7601748..7638913
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155785.1XP_036011678.1  katanin p60 ATPase-containing subunit A1 isoform X1

    Conserved Domains (3) summary
    pfam09336
    Location:366399
    Vps4_C; Vps4 C terminal oligomerization domain
    pfam17862
    Location:313357
    AAA_lid_3; AAA+ lid domain
    cd19522
    Location:120289
    RecA-like_KTNA1; Katanin p60 ATPase-containing subunit A1
  2. XM_030245091.2XP_030100951.1  katanin p60 ATPase-containing subunit A1 isoform X2

    Conserved Domains (1) summary
    COG0464
    Location:3256
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]