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ATE1 arginyltransferase 1 [ Homo sapiens (human) ]

Gene ID: 11101, updated on 13-Aug-2020

Summary

Official Symbol
ATE1provided by HGNC
Official Full Name
arginyltransferase 1provided by HGNC
Primary source
HGNC:HGNC:782
See related
Ensembl:ENSG00000107669 MIM:607103
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes an arginyltransferase, an enzyme that is involved in posttranslational conjugation of arginine to N-terminal aspartate or glutamate residues. Conjugation of arginine to the N-terminal aspartate or glutamate targets proteins for ubiquitin-dependent degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Expression
Ubiquitous expression in thyroid (RPKM 8.9), testis (RPKM 7.9) and 25 other tissues See more
Orthologs

Genomic context

See ATE1 in Genome Data Viewer
Location:
10q26.13
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (121740421..121928801, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (123499939..123688149, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984183 Neighboring gene ribosomal protein S15a pseudogene 5 Neighboring gene ATE1 antisense RNA 1 Neighboring gene NSE4 homolog A, SMC5-SMC6 complex component Neighboring gene transforming acidic coiled-coil containing protein 2 Neighboring gene Sharpr-MPRA regulatory regions 8460 and 2354

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC26724

Gene Ontology Provided by GOA

Function Evidence Code Pubs
arginyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
arginyltransferase activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
proteasomal protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein arginylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein arginylation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
arginyl-tRNA--protein transferase 1
Names
R-transferase 1
arginine-tRNA--protein transferase 1
arginyl-tRNA-protein transferase
NP_001001976.1
NP_001275663.1
NP_001275664.1
NP_001275665.1
NP_008972.2
XP_005269515.1
XP_005269516.1
XP_016871086.1
XP_016871087.1
XP_016871088.1
XP_016871089.1
XP_016871090.1
XP_016871091.1
XP_016871092.1
XP_016871093.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001976.2NP_001001976.1  arginyl-tRNA--protein transferase 1 isoform 1

    See identical proteins and their annotated locations for NP_001001976.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC025947, AF079098, AK124669, AL731566, HY046979
    Consensus CDS
    CCDS31300.1
    UniProtKB/Swiss-Prot
    O95260
    UniProtKB/TrEMBL
    B3KWA3
    Related
    ENSP00000224652.6, ENST00000224652.10
    Conserved Domains (2) summary
    pfam04376
    Location:2192
    ATE_N; Arginine-tRNA-protein transferase, N terminus
    pfam04377
    Location:290431
    ATE_C; Arginine-tRNA-protein transferase, C terminus
  2. NM_001288734.1NP_001275663.1  arginyl-tRNA--protein transferase 1 isoform 3

    See identical proteins and their annotated locations for NP_001275663.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC025947, AF079098, AK124669, AK296356, AK303604, HY046979
    Consensus CDS
    CCDS73211.1
    UniProtKB/Swiss-Prot
    O95260
    UniProtKB/TrEMBL
    B3KWA3, B4DK25, B4E107
    Related
    ENSP00000444852.1
    Conserved Domains (1) summary
    pfam04377
    Location:175316
    ATE_C; Arginine-tRNA-protein transferase, C terminus
  3. NM_001288735.1NP_001275664.1  arginyl-tRNA--protein transferase 1 isoform 4

    See identical proteins and their annotated locations for NP_001275664.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in its 5' UTR, initiates translation at a downstream start codon, and uses an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (4) has a shorter N-terminus and a unique internal segment, compared to isoform 1.
    Source sequence(s)
    AC025947, AF079099, AK124669, AK303604, AL731566, HY046979
    Consensus CDS
    CCDS73212.1
    UniProtKB/Swiss-Prot
    O95260
    UniProtKB/TrEMBL
    B3KWA3, B4E107
    Related
    ENSP00000358036.3, ENST00000369040.7
    Conserved Domains (1) summary
    pfam04377
    Location:198335
    ATE_C; Arginine-tRNA-protein transferase, C terminus
  4. NM_001288736.1NP_001275665.1  arginyl-tRNA--protein transferase 1 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding region, and uses an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (5) has a shorter and distinct N-terminus and a unique internal segment, compared to isoform 1.
    Source sequence(s)
    AC025947, AF079098, AF079099, AK124669, AL731566
    Consensus CDS
    CCDS73213.1
    UniProtKB/Swiss-Prot
    O95260
    UniProtKB/TrEMBL
    B3KWA3, F5GXE4
    Related
    ENSP00000440881.1, ENST00000540606.5
    Conserved Domains (2) summary
    pfam04376
    Location:1485
    ATE_N; Arginine-tRNA-protein transferase, N terminus
    pfam04377
    Location:287424
    ATE_C; Arginine-tRNA-protein transferase, C terminus
  5. NM_007041.4NP_008972.2  arginyl-tRNA--protein transferase 1 isoform 2

    See identical proteins and their annotated locations for NP_008972.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is the same length as isoform 1 but has a unique internal segment.
    Source sequence(s)
    AC025947, AL731542, AL731566
    Consensus CDS
    CCDS31299.1
    UniProtKB/Swiss-Prot
    O95260
    UniProtKB/TrEMBL
    B3KWA3
    Related
    ENSP00000358039.3, ENST00000369043.7
    Conserved Domains (2) summary
    pfam04376
    Location:2192
    ATE_N; Arginine-tRNA-protein transferase, N terminus
    pfam04377
    Location:294431
    ATE_C; Arginine-tRNA-protein transferase, C terminus

RNA

  1. NR_110006.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate 5'-terminal exon and lacks two internal exons, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AC025947, AL731542, AL731566

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    121740421..121928801 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005269459.3XP_005269516.1  arginyl-tRNA--protein transferase 1 isoform X3

    Conserved Domains (2) summary
    pfam04376
    Location:1485
    ATE_N; Arginine-tRNA-protein transferase, N terminus
    pfam04377
    Location:330467
    ATE_C; Arginine-tRNA-protein transferase, C terminus
  2. XM_017015598.2XP_016871087.1  arginyl-tRNA--protein transferase 1 isoform X4

  3. XM_017015599.2XP_016871088.1  arginyl-tRNA--protein transferase 1 isoform X5

  4. XM_005269458.3XP_005269515.1  arginyl-tRNA--protein transferase 1 isoform X2

    Conserved Domains (2) summary
    pfam04376
    Location:2192
    ATE_N; Arginine-tRNA-protein transferase, N terminus
    pfam04377
    Location:337474
    ATE_C; Arginine-tRNA-protein transferase, C terminus
  5. XM_017015604.1XP_016871093.1  arginyl-tRNA--protein transferase 1 isoform X10

  6. XM_017015602.1XP_016871091.1  arginyl-tRNA--protein transferase 1 isoform X8

  7. XM_017015600.1XP_016871089.1  arginyl-tRNA--protein transferase 1 isoform X6

  8. XM_017015597.1XP_016871086.1  arginyl-tRNA--protein transferase 1 isoform X1

  9. XM_017015603.1XP_016871092.1  arginyl-tRNA--protein transferase 1 isoform X9

  10. XM_017015601.2XP_016871090.1  arginyl-tRNA--protein transferase 1 isoform X7

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