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ATE1 arginyltransferase 1 [ Homo sapiens (human) ]

Gene ID: 11101, updated on 4-Dec-2022

Summary

Official Symbol
ATE1provided by HGNC
Official Full Name
arginyltransferase 1provided by HGNC
Primary source
HGNC:HGNC:782
See related
Ensembl:ENSG00000107669 MIM:607103; AllianceGenome:HGNC:782
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes an arginyltransferase, an enzyme that is involved in posttranslational conjugation of arginine to N-terminal aspartate or glutamate residues. Conjugation of arginine to the N-terminal aspartate or glutamate targets proteins for ubiquitin-dependent degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Expression
Ubiquitous expression in thyroid (RPKM 8.9), testis (RPKM 7.9) and 25 other tissues See more
Orthologs
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Genomic context

See ATE1 in Genome Data Viewer
Location:
10q26.13
Exon count:
19
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (121740424..121928463, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (122636555..122824802, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (123499939..123687978, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984183 Neighboring gene ribosomal protein S15a pseudogene 5 Neighboring gene Sharpr-MPRA regulatory region 2750 Neighboring gene ATE1 antisense RNA 1 Neighboring gene uncharacterized LOC124902517 Neighboring gene NSE4 homolog A, SMC5-SMC6 complex component

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC26724

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables arginyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables arginyltransferase activity TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within proteasomal protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein arginylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein arginylation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
arginyl-tRNA--protein transferase 1
Names
R-transferase 1
arginine-tRNA--protein transferase 1
arginyl-tRNA-protein transferase
NP_001001976.1
NP_001275663.1
NP_001275664.1
NP_001275665.1
NP_008972.2
XP_005269515.1
XP_005269516.1
XP_016871086.2
XP_016871087.1
XP_016871088.1
XP_016871090.2
XP_016871092.2
XP_047280477.1
XP_047280478.1
XP_047280479.1
XP_047280480.1
XP_047280481.1
XP_047280482.1
XP_047280483.1
XP_047280484.1
XP_047280485.1
XP_047280486.1
XP_047280487.1
XP_047280488.1
XP_047280489.1
XP_047280490.1
XP_047280491.1
XP_047280492.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001976.3NP_001001976.1  arginyl-tRNA--protein transferase 1 isoform 1

    See identical proteins and their annotated locations for NP_001001976.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC025947, AL731542, AL731566
    Consensus CDS
    CCDS31300.1
    UniProtKB/Swiss-Prot
    O95260, Q8WW04
    UniProtKB/TrEMBL
    B3KWA3
    Related
    ENSP00000224652.6, ENST00000224652.12
    Conserved Domains (2) summary
    pfam04376
    Location:2192
    ATE_N; Arginine-tRNA-protein transferase, N terminus
    pfam04377
    Location:290431
    ATE_C; Arginine-tRNA-protein transferase, C terminus
  2. NM_001288734.2NP_001275663.1  arginyl-tRNA--protein transferase 1 isoform 3

    See identical proteins and their annotated locations for NP_001275663.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC025947, AL731542, AL731566
    UniProtKB/Swiss-Prot
    O95260
    UniProtKB/TrEMBL
    B3KWA3, B4DK25, B4E107
    Conserved Domains (1) summary
    pfam04377
    Location:175316
    ATE_C; Arginine-tRNA-protein transferase, C terminus
  3. NM_001288735.2NP_001275664.1  arginyl-tRNA--protein transferase 1 isoform 4

    See identical proteins and their annotated locations for NP_001275664.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in its 5' UTR, initiates translation at a downstream start codon, and uses an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (4) has a shorter N-terminus and a unique internal segment, compared to isoform 1.
    Source sequence(s)
    AC025947, AL731542, AL731566
    UniProtKB/Swiss-Prot
    O95260
    UniProtKB/TrEMBL
    B3KWA3, B4E107
    Related
    ENSP00000509714.1, ENST00000693276.1
    Conserved Domains (1) summary
    pfam04377
    Location:198335
    ATE_C; Arginine-tRNA-protein transferase, C terminus
  4. NM_001288736.2NP_001275665.1  arginyl-tRNA--protein transferase 1 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding region, and uses an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (5) has a shorter and distinct N-terminus and a unique internal segment, compared to isoform 1.
    Source sequence(s)
    AC025947, AL731542, AL731566
    Consensus CDS
    CCDS73213.1
    UniProtKB/Swiss-Prot
    O95260
    UniProtKB/TrEMBL
    B3KWA3, F5GXE4
    Related
    ENSP00000440881.1, ENST00000540606.7
    Conserved Domains (2) summary
    pfam04376
    Location:1485
    ATE_N; Arginine-tRNA-protein transferase, N terminus
    pfam04377
    Location:287424
    ATE_C; Arginine-tRNA-protein transferase, C terminus
  5. NM_007041.4NP_008972.2  arginyl-tRNA--protein transferase 1 isoform 2

    See identical proteins and their annotated locations for NP_008972.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is the same length as isoform 1 but has a unique internal segment.
    Source sequence(s)
    AC025947, AL731542, AL731566
    Consensus CDS
    CCDS31299.1
    UniProtKB/Swiss-Prot
    O95260
    UniProtKB/TrEMBL
    B3KWA3
    Related
    ENSP00000358039.3, ENST00000369043.8
    Conserved Domains (2) summary
    pfam04376
    Location:2192
    ATE_N; Arginine-tRNA-protein transferase, N terminus
    pfam04377
    Location:294431
    ATE_C; Arginine-tRNA-protein transferase, C terminus

RNA

  1. NR_110006.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate 5'-terminal exon and lacks two internal exons, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AC025947, AL731542, AL731566
    Related
    ENST00000692718.1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    121740424..121928463 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047424532.1XP_047280488.1  arginyl-tRNA--protein transferase 1 isoform X16

  2. XM_047424530.1XP_047280486.1  arginyl-tRNA--protein transferase 1 isoform X13

  3. XM_017015598.3XP_016871087.1  arginyl-tRNA--protein transferase 1 isoform X11

    UniProtKB/TrEMBL
    A0A8I5KTH0
    Related
    ENSP00000509590.1, ENST00000689571.1
  4. XM_047424523.1XP_047280479.1  arginyl-tRNA--protein transferase 1 isoform X6

  5. XM_005269459.4XP_005269516.1  arginyl-tRNA--protein transferase 1 isoform X4

    Conserved Domains (2) summary
    pfam04376
    Location:1485
    ATE_N; Arginine-tRNA-protein transferase, N terminus
    pfam04377
    Location:330467
    ATE_C; Arginine-tRNA-protein transferase, C terminus
  6. XM_017015599.3XP_016871088.1  arginyl-tRNA--protein transferase 1 isoform X15

    UniProtKB/TrEMBL
    F8WAC9
    Related
    ENSP00000358036.4, ENST00000369040.9
  7. XM_047424529.1XP_047280485.1  arginyl-tRNA--protein transferase 1 isoform X12

  8. XM_047424522.1XP_047280478.1  arginyl-tRNA--protein transferase 1 isoform X5

  9. XM_005269458.4XP_005269515.1  arginyl-tRNA--protein transferase 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I5KZ24
    Related
    ENSP00000510433.1, ENST00000690355.1
    Conserved Domains (2) summary
    pfam04376
    Location:2192
    ATE_N; Arginine-tRNA-protein transferase, N terminus
    pfam04377
    Location:337474
    ATE_C; Arginine-tRNA-protein transferase, C terminus
  10. XM_047424527.1XP_047280483.1  arginyl-tRNA--protein transferase 1 isoform X9

    Related
    ENSP00000510033.1, ENST00000692278.1
  11. XM_047424525.1XP_047280481.1  arginyl-tRNA--protein transferase 1 isoform X8

    Related
    ENSP00000509487.1, ENST00000689393.1
  12. XM_017015597.2XP_016871086.2  arginyl-tRNA--protein transferase 1 isoform X2

  13. XM_047424521.1XP_047280477.1  arginyl-tRNA--protein transferase 1 isoform X1

  14. XM_047424528.1XP_047280484.1  arginyl-tRNA--protein transferase 1 isoform X10

  15. XM_047424524.1XP_047280480.1  arginyl-tRNA--protein transferase 1 isoform X7

    Related
    ENSP00000508420.1, ENST00000691573.1
  16. XM_047424531.1XP_047280487.1  arginyl-tRNA--protein transferase 1 isoform X14

  17. XM_047424526.1XP_047280482.1  arginyl-tRNA--protein transferase 1 isoform X9

  18. XM_047424533.1XP_047280489.1  arginyl-tRNA--protein transferase 1 isoform X17

  19. XM_017015603.2XP_016871092.2  arginyl-tRNA--protein transferase 1 isoform X19

  20. XM_047424536.1XP_047280492.1  arginyl-tRNA--protein transferase 1 isoform X22

    Related
    ENSP00000509863.1, ENST00000687251.1
  21. XM_047424534.1XP_047280490.1  arginyl-tRNA--protein transferase 1 isoform X20

  22. XM_017015601.3XP_016871090.2  arginyl-tRNA--protein transferase 1 isoform X18

  23. XM_047424535.1XP_047280491.1  arginyl-tRNA--protein transferase 1 isoform X21

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    122636555..122824802 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)