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Ate1 arginyltransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 11907, updated on 6-Jun-2024

Summary

Official Symbol
Ate1provided by MGI
Official Full Name
arginyltransferase 1provided by MGI
Primary source
MGI:MGI:1333870
See related
Ensembl:ENSMUSG00000030850 AllianceGenome:MGI:1333870
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables arginyltransferase activity. Acts upstream of or within protein arginylation. Located in cytoplasm and nucleus. Is expressed in several structures, including eye; genitourinary system; heart; nervous system; and notochord. Orthologous to human ATE1 (arginyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 5.0), CNS E18 (RPKM 4.1) and 28 other tissues See more
Orthologs
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Genomic context

See Ate1 in Genome Data Viewer
Location:
7 F3; 7 73.19 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (129993219..130122349, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (130391493..130520619, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33661 Neighboring gene predicted gene, 39097 Neighboring gene ring finger and WD repeat domain 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_20244 Neighboring gene VISTA enhancer mm938 Neighboring gene STARR-seq mESC enhancer starr_20245 Neighboring gene STARR-seq mESC enhancer starr_20247 Neighboring gene predicted gene 4275 Neighboring gene NSE4 homolog A, SMC5-SMC6 complex component Neighboring gene transforming, acidic coiled-coil containing protein 2 Neighboring gene STARR-seq mESC enhancer starr_20252 Neighboring gene predicted gene, 34365

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (4)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables arginyl-tRNA--protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables arginyl-tRNA--protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within proteasomal protein catabolic process ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in protein arginylation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within protein arginylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
arginyl-tRNA--protein transferase 1
Names
R-transferase 1
arginine-tRNA--protein transferase 1
NP_001025066.1
NP_001129526.1
NP_001258272.1
NP_001389570.1
NP_001389571.1
NP_001389572.1
NP_001389573.1
NP_001389574.1
NP_001389575.1
NP_001389576.1
NP_001389577.1
NP_038827.2
XP_011239961.1
XP_036008502.1
XP_036008503.1
XP_036008504.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001029895.4NP_001025066.1  arginyl-tRNA--protein transferase 1 isoform 3

    See identical proteins and their annotated locations for NP_001025066.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 5' structure, compared to variant 1. This difference causes translation initiation at an upstream AUG and results in an isoform (3) that has a distinct N-terminus and is shorter, compared to isoform 1.
    Source sequence(s)
    AC122258, AC157606
    Consensus CDS
    CCDS21901.1
    UniProtKB/TrEMBL
    Q4FCQ7, Q80YP1, Q8BP95
    Related
    ENSMUSP00000091556.4, ENSMUST00000094017.5
    Conserved Domains (2) summary
    pfam04376
    Location:1685
    ATE_N; Arginine-tRNA-protein transferase, N terminus
    pfam04377
    Location:281422
    ATE_C; Arginine-tRNA-protein transferase, C terminus
  2. NM_001136054.3NP_001129526.1  arginyl-tRNA--protein transferase 1 isoform 4

    See identical proteins and their annotated locations for NP_001129526.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame exon in the coding region, compared to variant 1. It encodes isoform 4.
    Source sequence(s)
    AC122258, AC157606
    Consensus CDS
    CCDS52414.1
    UniProtKB/TrEMBL
    Q80YP1
    Related
    ENSMUSP00000043365.8, ENSMUST00000035458.15
    Conserved Domains (2) summary
    pfam04376
    Location:2092
    ATE_N; Arginine-tRNA-protein transferase, N terminus
    pfam04377
    Location:288429
    ATE_C; Arginine-tRNA-protein transferase, C terminus
  3. NM_001271343.2NP_001258272.1  arginyl-tRNA--protein transferase 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' structure and an alternate in-frame exon in the coding region, compared to variant 1. These differences cause translation initiation at an upstream AUG and result in an isoform (2) that has a distinct N-terminus and is shorter, compared to isoform 1.
    Source sequence(s)
    AC122258, AC157606
    Consensus CDS
    CCDS72051.1
    UniProtKB/TrEMBL
    J3QNU1
    Related
    ENSMUSP00000136956.2, ENSMUST00000178534.8
    Conserved Domains (2) summary
    pfam04376
    Location:1685
    ATE_N; Arginine-tRNA-protein transferase, N-terminus
    pfam04377
    Location:282420
    ATE_C; Arginine-tRNA-protein transferase, C-terminus
  4. NM_001402641.1NP_001389570.1  arginyl-tRNA--protein transferase 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC122258, AC157606
    UniProtKB/TrEMBL
    A0A1L1SQ41
    Related
    ENSMUSP00000148888.2, ENSMUST00000216011.2
  5. NM_001402642.1NP_001389571.1  arginyl-tRNA--protein transferase 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC122258, AC157606
  6. NM_001402643.1NP_001389572.1  arginyl-tRNA--protein transferase 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC122258, AC157606
  7. NM_001402644.1NP_001389573.1  arginyl-tRNA--protein transferase 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC122258, AC157606
  8. NM_001402645.1NP_001389574.1  arginyl-tRNA--protein transferase 1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC122258, AC157606
    UniProtKB/TrEMBL
    Q8BP95
  9. NM_001402646.1NP_001389575.1  arginyl-tRNA--protein transferase 1 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC122258
  10. NM_001402647.1NP_001389576.1  arginyl-tRNA--protein transferase 1 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC122258
  11. NM_001402648.1NP_001389577.1  arginyl-tRNA--protein transferase 1 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC122258
  12. NM_013799.4NP_038827.2  arginyl-tRNA--protein transferase 1 isoform 1

    See identical proteins and their annotated locations for NP_038827.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC122258, AC157606
    Consensus CDS
    CCDS21902.1
    UniProtKB/Swiss-Prot
    Q4FCQ6, Q4FCQ7, Q8CFP7, Q9Z2A4, Q9Z2A5
    Related
    ENSMUSP00000033139.8, ENSMUST00000033139.15
    Conserved Domains (2) summary
    pfam04376
    Location:2392
    ATE_N; Arginine-tRNA-protein transferase, N-terminus
    pfam04377
    Location:288427
    ATE_C; Arginine-tRNA-protein transferase, C-terminus

RNA

  1. NR_175281.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC122258, AC157606

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    129993219..130122349 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152610.1XP_036008503.1  arginyl-tRNA--protein transferase 1 isoform X5

    Conserved Domains (2) summary
    pfam04376
    Location:2392
    ATE_N; Arginine-tRNA-protein transferase, N-terminus
    pfam04377
    Location:288418
    ATE_C; Arginine-tRNA-protein transferase, C-terminus
  2. XM_036152609.1XP_036008502.1  arginyl-tRNA--protein transferase 1 isoform X3

    Conserved Domains (2) summary
    pfam04376
    Location:2392
    ATE_N; Arginine-tRNA-protein transferase, N-terminus
    pfam04377
    Location:331461
    ATE_C; Arginine-tRNA-protein transferase, C-terminus
  3. XM_036152611.1XP_036008504.1  arginyl-tRNA--protein transferase 1 isoform X7

    Conserved Domains (1) summary
    pfam04377
    Location:34173
    ATE_C; Arginine-tRNA-protein transferase, C-terminus
  4. XM_011241659.1XP_011239961.1  arginyl-tRNA--protein transferase 1 isoform X4

    Conserved Domains (2) summary
    pfam04376
    Location:2392
    ATE_N; Arginine-tRNA-protein transferase, N-terminus
    pfam04377
    Location:331460
    ATE_C; Arginine-tRNA-protein transferase, C-terminus

RNA

  1. XR_004934000.1 RNA Sequence

  2. XR_004933999.1 RNA Sequence

  3. XR_004934001.1 RNA Sequence