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PRSS23 serine protease 23 [ Homo sapiens (human) ]

Gene ID: 11098, updated on 7-Jun-2020

Summary

Official Symbol
PRSS23provided by HGNC
Official Full Name
serine protease 23provided by HGNC
Primary source
HGNC:HGNC:14370
See related
Ensembl:ENSG00000150687 MIM:618376
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SIG13; SPUVE; ZSIG13
Summary
This gene encodes a conserved member of the trypsin family of serine proteases. Mouse studies found a decrease of mRNA levels of this gene after ovulation was induced. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Expression
Ubiquitous expression in gall bladder (RPKM 19.0), urinary bladder (RPKM 17.9) and 24 other tissues See more
Orthologs

Genomic context

See PRSS23 in Genome Data Viewer
Location:
11q14.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (86791071..86952910)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (86511288..86522275)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ME3 divergent transcript Neighboring gene Sharpr-MPRA regulatory region 8285 Neighboring gene uncharacterized LOC102724775 Neighboring gene MOB4 pseudogene 2 Neighboring gene olfactory receptor family 7 subfamily E member 13 pseudogene Neighboring gene uncharacterized LOC112268086 Neighboring gene olfactory receptor family 7 subfamily E member 2 pseudogene Neighboring gene uncharacterized LOC107984429 Neighboring gene uncharacterized LOC107984428 Neighboring gene FZD4 divergent transcript Neighboring gene frizzled class receptor 4 Neighboring gene uncharacterized LOC105369422 Neighboring gene heterogeneous nuclear ribonucleoprotein C pseudogene 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC5107, DKFZp451O043

Gene Ontology Provided by GOA

Function Evidence Code Pubs
serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
post-translational protein modification TAS
Traceable Author Statement
more info
 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
nucleus IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
serine protease 23
Names
protease, serine 23
putative secreted protein Zsig13
serine protease, umbilical endothelium

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001293179.2NP_001280108.1  serine protease 23 precursor

    See identical proteins and their annotated locations for NP_001280108.1

    Status: REVIEWED

    Source sequence(s)
    AP000654, BP206707
    Consensus CDS
    CCDS8278.1
    UniProtKB/Swiss-Prot
    O95084
    Conserved Domains (1) summary
    cl21584
    Location:147255
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  2. NM_001293180.2NP_001280109.1  serine protease 23 precursor

    See identical proteins and their annotated locations for NP_001280109.1

    Status: REVIEWED

    Source sequence(s)
    AP000654, DA895063
    Consensus CDS
    CCDS8278.1
    UniProtKB/Swiss-Prot
    O95084
    Conserved Domains (1) summary
    cl21584
    Location:147255
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  3. NM_007173.6NP_009104.3  serine protease 23 precursor

    Status: REVIEWED

    Source sequence(s)
    AP000654, DA910788
    Related
    ENSP00000280258.4, ENST00000280258.6
    Conserved Domains (1) summary
    cl21584
    Location:147255
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RNA

  1. NR_120591.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an exon and contains four alternate 3' exons, compared to variant 1. This variant is represented as non-coding because its lacks the ORF found in variant 1.
    Source sequence(s)
    BC063022, BU634437, CX871294
    Related
    ENST00000532234.5
  2. NR_120592.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an exon and contains two alternate 3' exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AP000654, AP001528
    Related
    ENST00000533902.2
  3. NR_120593.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks an exon and contains two alternate 3' exons, compared to variant 1. This variant is represented as non-coding because it lacks the ORF found in variant 1.
    Source sequence(s)
    AP001528, CX871294, DA600625

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    86791071..86952910
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001293178.1: Suppressed sequence

    Description
    NM_001293178.1: This RefSeq was removed because currently there is insufficient support for the transcript and protein.
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