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Prss23 serine protease 23 [ Mus musculus (house mouse) ]

Gene ID: 76453, updated on 6-Jun-2024

Summary

Official Symbol
Prss23provided by MGI
Official Full Name
serine protease 23provided by MGI
Primary source
MGI:MGI:1923703
See related
Ensembl:ENSMUSG00000039405 AllianceGenome:MGI:1923703
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Spuve; 2310046G15Rik; 4930479H08Rik
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Located in extracellular space. Is expressed in cochlear duct; early conceptus; genitourinary system; incisor; and skeleton. Orthologous to human PRSS23 (serine protease 23). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 53.0), ovary adult (RPKM 40.2) and 18 other tissues See more
Orthologs
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Genomic context

See Prss23 in Genome Data Viewer
Location:
7 D3; 7 49.9 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (89156988..89176399, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (89507783..89527187, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 135 Neighboring gene expressed sequence AI314278 Neighboring gene frizzled class receptor 4 Neighboring gene STARR-seq mESC enhancer starr_19491 Neighboring gene STARR-seq mESC enhancer starr_19492 Neighboring gene STARR-seq mESC enhancer starr_19493 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 53381 Neighboring gene malic enzyme 3, NADP(+)-dependent, mitochondrial

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space HDA PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
serine protease 23
Names
protease, serine 23
NP_001347681.2
NP_001347682.2
NP_001347683.2
NP_001347684.1
NP_001347685.1
NP_001371077.2
NP_001371080.1
NP_001402962.1
NP_001402963.1
NP_083890.2
XP_036009434.1
XP_036009435.1
XP_036009438.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360752.2NP_001347681.2  serine protease 23 precursor

    Status: VALIDATED

    Source sequence(s)
    AC116326
    UniProtKB/Swiss-Prot
    Q544M8, Q8VEG1, Q9D6X6
    UniProtKB/TrEMBL
    Q8BZS4
    Related
    ENSMUSP00000147183.2, ENSMUST00000207932.2
  2. NM_001360753.2NP_001347682.2  serine protease 23 precursor

    Status: VALIDATED

    Source sequence(s)
    AC116326
    UniProtKB/Swiss-Prot
    Q544M8, Q8VEG1, Q9D6X6
    UniProtKB/TrEMBL
    Q8BZS4
  3. NM_001360754.2NP_001347683.2  serine protease 23 precursor

    Status: VALIDATED

    Source sequence(s)
    AC116326
    UniProtKB/Swiss-Prot
    Q544M8, Q8VEG1, Q9D6X6
    UniProtKB/TrEMBL
    Q8BZS4
  4. NM_001360755.2NP_001347684.1  serine protease 23 precursor

    Status: VALIDATED

    Source sequence(s)
    AC116326
    Consensus CDS
    CCDS21442.1
    UniProtKB/Swiss-Prot
    Q544M8, Q8VEG1, Q9D6X6
    UniProtKB/TrEMBL
    Q8BZS4
    Conserved Domains (1) summary
    cl21584
    Location:146254
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  5. NM_001360756.2NP_001347685.1  serine protease 23 precursor

    Status: VALIDATED

    Source sequence(s)
    AC116326
    Consensus CDS
    CCDS21442.1
    UniProtKB/Swiss-Prot
    Q544M8, Q8VEG1, Q9D6X6
    UniProtKB/TrEMBL
    Q8BZS4
    Conserved Domains (1) summary
    cl21584
    Location:146254
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  6. NM_001384148.2NP_001371077.2  serine protease 23 precursor

    Status: VALIDATED

    Source sequence(s)
    AC116326
    UniProtKB/Swiss-Prot
    Q544M8, Q8VEG1, Q9D6X6
    UniProtKB/TrEMBL
    Q8BZS4
  7. NM_001384151.2NP_001371080.1  serine protease 23 precursor

    Status: VALIDATED

    Source sequence(s)
    AC116326
    UniProtKB/Swiss-Prot
    Q544M8, Q8VEG1, Q9D6X6
    UniProtKB/TrEMBL
    Q8BZS4
    Conserved Domains (1) summary
    cl21584
    Location:146254
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  8. NM_001416033.1NP_001402962.1  serine protease 23 precursor

    Status: VALIDATED

    Source sequence(s)
    AC116326
    UniProtKB/Swiss-Prot
    Q544M8, Q8VEG1, Q9D6X6
    UniProtKB/TrEMBL
    Q8BZS4
  9. NM_001416034.1NP_001402963.1  serine protease 23 precursor

    Status: VALIDATED

    Source sequence(s)
    AC116326
    UniProtKB/Swiss-Prot
    Q544M8, Q8VEG1, Q9D6X6
    UniProtKB/TrEMBL
    Q8BZS4
  10. NM_029614.5NP_083890.2  serine protease 23 precursor

    See identical proteins and their annotated locations for NP_083890.2

    Status: VALIDATED

    Source sequence(s)
    AC116326
    Consensus CDS
    CCDS21442.1
    UniProtKB/Swiss-Prot
    Q544M8, Q8VEG1, Q9D6X6
    UniProtKB/TrEMBL
    Q8BZS4
    Related
    ENSMUSP00000045191.6, ENSMUST00000041761.7
    Conserved Domains (1) summary
    cl21584
    Location:146254
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    89156988..89176399 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153541.1XP_036009434.1  serine protease 23 isoform X1

    UniProtKB/TrEMBL
    Q8BZS4
    Conserved Domains (1) summary
    cl21584
    Location:187295
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  2. XM_036153542.1XP_036009435.1  serine protease 23 isoform X2

    UniProtKB/TrEMBL
    Q8BZS4
    Conserved Domains (1) summary
    cl21584
    Location:154262
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  3. XM_036153545.1XP_036009438.1  serine protease 23 isoform X4

    UniProtKB/Swiss-Prot
    Q544M8, Q8VEG1, Q9D6X6
    UniProtKB/TrEMBL
    Q8BZS4
    Conserved Domains (1) summary
    cl21584
    Location:146254
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...