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Mbd6 methyl-CpG binding domain protein 6 [ Mus musculus (house mouse) ]

Gene ID: 110962, updated on 26-Sep-2022

Summary

Official Symbol
Mbd6provided by MGI
Official Full Name
methyl-CpG binding domain protein 6provided by MGI
Primary source
MGI:MGI:106378
See related
Ensembl:ENSMUSG00000025409 AllianceGenome:MGI:106378
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D10Wsu93e
Summary
Predicted to enable chromatin binding activity. Predicted to be located in fibrillar center and nucleoplasm. Predicted to be active in chromocenter and nucleus. Is expressed in several structures, including adipose tissue; alimentary system; immune system; nervous system; and reproductive system. Human ortholog(s) of this gene implicated in autism spectrum disorder. Orthologous to human MBD6 (methyl-CpG binding domain protein 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 36.9), thymus adult (RPKM 30.4) and 28 other tissues See more
Orthologs
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Genomic context

See Mbd6 in Genome Data Viewer
Location:
10 D3; 10 74.5 cM
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (127117825..127126738, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (127281956..127290869, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA F420014N23 gene Neighboring gene phosphatidylinositol-5-phosphate 4-kinase, type II, gamma Neighboring gene kinesin family member 5A Neighboring gene predicted gene, 40800 Neighboring gene dynactin 2 Neighboring gene DNA-damage inducible transcript 3 Neighboring gene methionine-tRNA synthetase 1 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
is_active_in chromocenter IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in chromocenter ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
methyl-CpG-binding domain protein 6
Names
methyl-CpG-binding protein MBD6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347171.1NP_001334100.1  methyl-CpG-binding domain protein 6 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses two alternate in-frame splice sites in the 3' coding region, compared to variant 1. The encoded isoform (2) has the same N- and C-termiini, but is 2 aa shorter than isoform 1.
    Source sequence(s)
    AC144852, AK158797, BC059015, BC083328, BC096027
    Consensus CDS
    CCDS83762.1
    UniProtKB/Swiss-Prot
    E9PWH8, Q3TY92
    UniProtKB/TrEMBL
    Q4VBD6, Q5XJH3
    Related
    ENSMUSP00000112805.2, ENSMUST00000119078.8
    Conserved Domains (2) summary
    PHA03247
    Location:379836
    PHA03247; large tegument protein UL36; Provisional
    cl00110
    Location:2186
    MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...
  2. NM_001379570.1NP_001366499.1  methyl-CpG-binding domain protein 6 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC144852
    Conserved Domains (2) summary
    PHA03247
    Location:6871004
    PHA03247; large tegument protein UL36; Provisional
    cl00110
    Location:2186
    MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...
  3. NM_001379571.1NP_001366500.1  methyl-CpG-binding domain protein 6 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC144852
    Conserved Domains (2) summary
    PHA03247
    Location:394847
    PHA03247; large tegument protein UL36; Provisional
    cl00110
    Location:2186
    MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...
  4. NM_033072.3NP_149063.2  methyl-CpG-binding domain protein 6 isoform 1

    See identical proteins and their annotated locations for NP_149063.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC144852, AK158797, BC059015, BC083328, BC096027
    Consensus CDS
    CCDS24235.1
    UniProtKB/Swiss-Prot
    Q3TY92
    UniProtKB/TrEMBL
    A0A8C6G6U8, E9Q572, Q4VBD6, Q5XJH3
    Related
    ENSMUSP00000026476.7, ENSMUST00000026476.13
    Conserved Domains (2) summary
    PHA03247
    Location:379838
    PHA03247; large tegument protein UL36; Provisional
    cl00110
    Location:2186
    MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    127117825..127126738 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244825.1XP_030100685.1  methyl-CpG-binding domain protein 6 isoform X1

    UniProtKB/TrEMBL
    A0A8C6G6U8, E9Q572
    Conserved Domains (2) summary
    PHA03247
    Location:379838
    PHA03247; large tegument protein UL36; Provisional
    cl00110
    Location:2186
    MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...
  2. XM_011243266.2XP_011241568.1  methyl-CpG-binding domain protein 6 isoform X1

    See identical proteins and their annotated locations for XP_011241568.1

    UniProtKB/TrEMBL
    A0A8C6G6U8, E9Q572
    Conserved Domains (2) summary
    PHA03247
    Location:379838
    PHA03247; large tegument protein UL36; Provisional
    cl00110
    Location:2186
    MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...
  3. XM_011243267.3XP_011241569.1  methyl-CpG-binding domain protein 6 isoform X1

    See identical proteins and their annotated locations for XP_011241569.1

    UniProtKB/TrEMBL
    A0A8C6G6U8, E9Q572
    Conserved Domains (2) summary
    PHA03247
    Location:379838
    PHA03247; large tegument protein UL36; Provisional
    cl00110
    Location:2186
    MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...
  4. XM_011243270.4XP_011241572.1  methyl-CpG-binding domain protein 6 isoform X1

    See identical proteins and their annotated locations for XP_011241572.1

    UniProtKB/TrEMBL
    A0A8C6G6U8, E9Q572
    Conserved Domains (2) summary
    PHA03247
    Location:379838
    PHA03247; large tegument protein UL36; Provisional
    cl00110
    Location:2186
    MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...
  5. XM_011243268.4XP_011241570.1  methyl-CpG-binding domain protein 6 isoform X1

    See identical proteins and their annotated locations for XP_011241570.1

    UniProtKB/TrEMBL
    A0A8C6G6U8, E9Q572
    Conserved Domains (2) summary
    PHA03247
    Location:379838
    PHA03247; large tegument protein UL36; Provisional
    cl00110
    Location:2186
    MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...
  6. XM_011243269.4XP_011241571.1  methyl-CpG-binding domain protein 6 isoform X1

    See identical proteins and their annotated locations for XP_011241571.1

    UniProtKB/TrEMBL
    A0A8C6G6U8, E9Q572
    Conserved Domains (2) summary
    PHA03247
    Location:379838
    PHA03247; large tegument protein UL36; Provisional
    cl00110
    Location:2186
    MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...
  7. XM_030244826.1XP_030100686.1  methyl-CpG-binding domain protein 6 isoform X1

    UniProtKB/TrEMBL
    A0A8C6G6U8, E9Q572
    Conserved Domains (2) summary
    PHA03247
    Location:379838
    PHA03247; large tegument protein UL36; Provisional
    cl00110
    Location:2186
    MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...

RNA

  1. XR_003948576.2 RNA Sequence

  2. XR_003948578.1 RNA Sequence

  3. XR_003948577.1 RNA Sequence

  4. XR_871687.3 RNA Sequence