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MBD6 methyl-CpG binding domain protein 6 [ Homo sapiens (human) ]

Gene ID: 114785, updated on 7-Jun-2020

Summary

Official Symbol
MBD6provided by HGNC
Official Full Name
methyl-CpG binding domain protein 6provided by HGNC
Primary source
HGNC:HGNC:20445
See related
Ensembl:ENSG00000166987
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in testis (RPKM 15.8), spleen (RPKM 15.7) and 25 other tissues See more
Orthologs

Genomic context

See MBD6 in Genome Data Viewer
Location:
12q13.3
Exon count:
17
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (57520710..57530148)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (57915463..57923931)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene methionyl-tRNA synthetase 1 Neighboring gene microRNA 6758 Neighboring gene DNA damage inducible transcript 3 Neighboring gene microRNA 616 Neighboring gene dynactin subunit 2 Neighboring gene kinesin family member 5A Neighboring gene phosphatidylinositol-5-phosphate 4-kinase type 2 gamma

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1887

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
protein deubiquitination TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
chromocenter IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromocenter IDA
Inferred from Direct Assay
more info
PubMed 
fibrillar center IDA
Inferred from Direct Assay
more info
 
host cell nucleus IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
methyl-CpG-binding domain protein 6
Names
methyl-CpG-binding protein MBD6

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_052897.4NP_443129.3  methyl-CpG-binding domain protein 6

    See identical proteins and their annotated locations for NP_443129.3

    Status: VALIDATED

    Source sequence(s)
    AB067474, AC022506, AK056399
    Consensus CDS
    CCDS8944.1
    UniProtKB/Swiss-Prot
    Q96DN6
    UniProtKB/TrEMBL
    A0A024RBA3, Q6P0P0
    Related
    ENSP00000347896.3, ENST00000355673.8
    Conserved Domains (1) summary
    cl00110
    Location:1684
    MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    57520710..57530148
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006719217.1XP_006719280.1  methyl-CpG-binding domain protein 6 isoform X1

    See identical proteins and their annotated locations for XP_006719280.1

    Conserved Domains (1) summary
    cl00110
    Location:1684
    MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...
  2. XM_006719218.1XP_006719281.1  methyl-CpG-binding domain protein 6 isoform X1

    See identical proteins and their annotated locations for XP_006719281.1

    Conserved Domains (1) summary
    cl00110
    Location:1684
    MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...
  3. XM_011537851.3XP_011536153.1  methyl-CpG-binding domain protein 6 isoform X1

    See identical proteins and their annotated locations for XP_011536153.1

    Conserved Domains (1) summary
    cl00110
    Location:1684
    MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...
  4. XM_005268617.2XP_005268674.1  methyl-CpG-binding domain protein 6 isoform X1

    See identical proteins and their annotated locations for XP_005268674.1

    Conserved Domains (1) summary
    cl00110
    Location:1684
    MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...
  5. XM_005268620.3XP_005268677.1  methyl-CpG-binding domain protein 6 isoform X2

    Conserved Domains (1) summary
    cl00110
    Location:1684
    MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...
  6. XM_005268618.1XP_005268675.1  methyl-CpG-binding domain protein 6 isoform X1

    See identical proteins and their annotated locations for XP_005268675.1

    Conserved Domains (1) summary
    cl00110
    Location:1684
    MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...

RNA

  1. XR_429075.2 RNA Sequence

  2. XR_429073.2 RNA Sequence

  3. XR_429076.2 RNA Sequence

  4. XR_429078.2 RNA Sequence

  5. XR_002957286.1 RNA Sequence

  6. XR_429079.2 RNA Sequence

  7. XR_001748569.2 RNA Sequence

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