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WDR5 WD repeat domain 5 [ Homo sapiens (human) ]

Gene ID: 11091, updated on 25-Nov-2025
Official Symbol
WDR5provided by HGNC
Official Full Name
WD repeat domain 5provided by HGNC
Primary source
HGNC:HGNC:12757
See related
Ensembl:ENSG00000196363 MIM:609012; AllianceGenome:HGNC:12757
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BIG3; SWD3; BIG-3; CFAP89
Summary
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 24.2), skin (RPKM 8.5) and 25 other tissues See more
Orthologs
NEW
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Try the new Transcript table
See WDR5 in Genome Data Viewer
Location:
9q34.2
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (134135199..134159968)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (146348934..146373713)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (137000321..137025090)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene bromodomain containing 3 Neighboring gene uncharacterized LOC100130548 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136924735-136925476 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136927711-136928622 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20474 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20475 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr9:136956997-136957776 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr9:136957777-136958556 Neighboring gene ARF GTPase 4 pseudogene 1 Neighboring gene MPRA-validated peak7340 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136991223-136992104 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136992105-136992986 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136994027-136994872 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136994873-136995716 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136997435-136998004 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29270 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20476 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:137001261-137002185 Neighboring gene WDR5 divergent transcript Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:137016988-137017508 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:137017509-137018028 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:137028703-137029668 Neighboring gene uncharacterized LOC124902297 Neighboring gene RNA, U6atac small nuclear Neighboring gene uncharacterized LOC124902298 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29272 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29273 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:137095569-137096070 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:137096071-137096570

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Tat tat Three components (Setd1A, CXXC1, WDR5) of the Set1 histone methyltransferase complex are identified to interact with HIV-1 Tat in Jurkat cell PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables histone H3K4 methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3K4me1 reader activity IDA
Inferred from Direct Assay
more info
PubMed 
enables histone H3Q5ser reader activity IDA
Inferred from Direct Assay
more info
PubMed 
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within positive regulation of gluconeogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cell division IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell division ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of embryonic development IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of embryonic development ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of embryonic development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of tubulin deacetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of tubulin deacetylation ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within skeletal system development IEA
Inferred from Electronic Annotation
more info
 
involved_in transcription initiation-coupled chromatin remodeling IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of ATAC complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of ATAC complex IEA
Inferred from Electronic Annotation
more info
 
part_of ATAC complex ISO
Inferred from Sequence Orthology
more info
 
part_of MLL1 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of MLL1 complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of MLL1/2 complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of MLL3/4 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of MLL3/4 complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of NSL complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of Set1C/COMPASS complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of Set1C/COMPASS complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of Set1C/COMPASS complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of histone methyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitotic spindle NAS
Non-traceable Author Statement
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
WD repeat-containing protein 5
Names
BMP-2-induced gene 3 kb
BMP2-induced 3-kb gene protein
SWD3, Set1c WD40 repeat protein, homolog
cilia and flagella associated protein 89

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047125.1 RefSeqGene

    Range
    5404..29290
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001384409.1NP_001371338.1  WD repeat-containing protein 5 isoform 1

    Status: REVIEWED

    Source sequence(s)
    BX649632
    Consensus CDS
    CCDS6981.1
    UniProtKB/Swiss-Prot
    P61964, Q91VA5, Q9NWX7, Q9UGP9
    Related
    ENSP00000577954.1, ENST00000907895.1
    Conserved Domains (2) summary
    cd00200
    Location:37331
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:4885
    7WD40; WD40 repeat [structural motif]
  2. NM_001384410.1NP_001371339.1  WD repeat-containing protein 5 isoform 1

    Status: REVIEWED

    Source sequence(s)
    BX649632
    Consensus CDS
    CCDS6981.1
    UniProtKB/Swiss-Prot
    P61964, Q91VA5, Q9NWX7, Q9UGP9
    Conserved Domains (2) summary
    cd00200
    Location:37331
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:4885
    7WD40; WD40 repeat [structural motif]
  3. NM_001384411.1NP_001371340.1  WD repeat-containing protein 5 isoform 1

    Status: REVIEWED

    Source sequence(s)
    BX649632
    Consensus CDS
    CCDS6981.1
    UniProtKB/Swiss-Prot
    P61964, Q91VA5, Q9NWX7, Q9UGP9
    Related
    ENSP00000577957.1, ENST00000907898.1
    Conserved Domains (2) summary
    cd00200
    Location:37331
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:4885
    7WD40; WD40 repeat [structural motif]
  4. NM_001384412.1NP_001371341.1  WD repeat-containing protein 5 isoform 1

    Status: REVIEWED

    Source sequence(s)
    BX649632
    Consensus CDS
    CCDS6981.1
    UniProtKB/Swiss-Prot
    P61964, Q91VA5, Q9NWX7, Q9UGP9
    Related
    ENSP00000594722.1, ENST00000924663.1
    Conserved Domains (2) summary
    cd00200
    Location:37331
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:4885
    7WD40; WD40 repeat [structural motif]
  5. NM_001384413.1NP_001371342.1  WD repeat-containing protein 5 isoform 1

    Status: REVIEWED

    Source sequence(s)
    BX649632
    Consensus CDS
    CCDS6981.1
    UniProtKB/Swiss-Prot
    P61964, Q91VA5, Q9NWX7, Q9UGP9
    Conserved Domains (2) summary
    cd00200
    Location:37331
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:4885
    7WD40; WD40 repeat [structural motif]
  6. NM_001384414.1NP_001371343.1  WD repeat-containing protein 5 isoform 1

    Status: REVIEWED

    Source sequence(s)
    BX649632
    Consensus CDS
    CCDS6981.1
    UniProtKB/Swiss-Prot
    P61964, Q91VA5, Q9NWX7, Q9UGP9
    Related
    ENSP00000577953.1, ENST00000907894.1
    Conserved Domains (2) summary
    cd00200
    Location:37331
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:4885
    7WD40; WD40 repeat [structural motif]
  7. NM_001384415.1NP_001371344.1  WD repeat-containing protein 5 isoform 1

    Status: REVIEWED

    Source sequence(s)
    BX649632
    Consensus CDS
    CCDS6981.1
    UniProtKB/Swiss-Prot
    P61964, Q91VA5, Q9NWX7, Q9UGP9
    Conserved Domains (2) summary
    cd00200
    Location:37331
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:4885
    7WD40; WD40 repeat [structural motif]
  8. NM_001384416.1NP_001371345.1  WD repeat-containing protein 5 isoform 2

    Status: REVIEWED

    Source sequence(s)
    BX649632
    Conserved Domains (2) summary
    cd00200
    Location:37330
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:4885
    7WD40; WD40 repeat [structural motif]
  9. NM_001384417.1NP_001371346.1  WD repeat-containing protein 5 isoform 3

    Status: REVIEWED

    Source sequence(s)
    BX649632
    Conserved Domains (2) summary
    cd00200
    Location:37328
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:4885
    7WD40; WD40 repeat [structural motif]
  10. NM_001384418.1NP_001371347.1  WD repeat-containing protein 5 isoform 4

    Status: REVIEWED

    Source sequence(s)
    BX649632
    Conserved Domains (2) summary
    cd00200
    Location:37288
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:4984
    7WD40; WD40 repeat [structural motif]
  11. NM_001384419.1NP_001371348.1  WD repeat-containing protein 5 isoform 4

    Status: REVIEWED

    Source sequence(s)
    BX649632
    Conserved Domains (2) summary
    cd00200
    Location:37288
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:4984
    7WD40; WD40 repeat [structural motif]
  12. NM_017588.3NP_060058.1  WD repeat-containing protein 5 isoform 1

    See identical proteins and their annotated locations for NP_060058.1

    Status: REVIEWED

    Source sequence(s)
    AA490313, AK000552, BC029769, BG773451, BX649632
    Consensus CDS
    CCDS6981.1
    UniProtKB/Swiss-Prot
    P61964, Q91VA5, Q9NWX7, Q9UGP9
    Related
    ENSP00000351446.3, ENST00000358625.4
    Conserved Domains (2) summary
    cd00200
    Location:37331
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:4885
    7WD40; WD40 repeat [structural motif]
  13. NM_052821.4NP_438172.1  WD repeat-containing protein 5 isoform 1

    See identical proteins and their annotated locations for NP_438172.1

    Status: REVIEWED

    Source sequence(s)
    BX649632
    Consensus CDS
    CCDS6981.1
    UniProtKB/Swiss-Prot
    P61964, Q91VA5, Q9NWX7, Q9UGP9
    Related
    ENSP00000594720.1, ENST00000924661.1
    Conserved Domains (2) summary
    cd00200
    Location:37331
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:4885
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    134135199..134159968
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047422696.1XP_047278652.1  WD repeat-containing protein 5 isoform X1

    UniProtKB/Swiss-Prot
    P61964, Q91VA5, Q9NWX7, Q9UGP9
    Related
    ENSP00000627701.1, ENST00000957642.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    146348934..146373713
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054361853.1XP_054217828.1  WD repeat-containing protein 5 isoform X1

    UniProtKB/Swiss-Prot
    P61964, Q91VA5, Q9NWX7, Q9UGP9