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WDR5 WD repeat domain 5 [ Homo sapiens (human) ]

Gene ID: 11091, updated on 5-Dec-2021

Summary

Official Symbol
WDR5provided by HGNC
Official Full Name
WD repeat domain 5provided by HGNC
Primary source
HGNC:HGNC:12757
See related
Ensembl:ENSG00000196363 MIM:609012
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BIG3; SWD3; BIG-3; CFAP89
Summary
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 24.2), skin (RPKM 8.5) and 25 other tissues See more
Orthologs
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Try the new Transcript table

Genomic context

See WDR5 in Genome Data Viewer
Location:
9q34.2
Exon count:
17
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (134135199..134159968)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (137000321..137025090)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene bromodomain containing 3 Neighboring gene uncharacterized LOC100130548 Neighboring gene ADP ribosylation factor 4 pseudogene 1 Neighboring gene RNA, U6atac small nuclear (U12-dependent splicing) Neighboring gene uncharacterized LOC107987137

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Three components (Setd1A, CXXC1, WDR5) of the Set1 histone methyltransferase complex are identified to interact with HIV-1 Tat in Jurkat cell PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to histone methyltransferase activity (H3-K4 specific) IDA
Inferred from Direct Assay
more info
PubMed 
enables methylated histone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in histone H3 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in histone H3-K14 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in histone H3-K4 methylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in histone H3-K4 methylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in histone H4-K16 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in histone H4-K5 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in histone H4-K8 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of histone H3-K4 methylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neuron projection development IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of gluconeogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of histone H3-K4 methylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell division IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of histone deacetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of tubulin deacetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in skeletal system development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of ATAC complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of MLL1 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of MLL1 complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of MLL1/2 complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of MLL3/4 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of MLL3/4 complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of NSL complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of Set1C/COMPASS complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of Set1C/COMPASS complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of Set1C/COMPASS complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of histone methyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
WD repeat-containing protein 5
Names
BMP2-induced 3-kb gene protein
SWD3, Set1c WD40 repeat protein, homolog
cilia and flagella associated protein 89

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047125.1 RefSeqGene

    Range
    5404..29290
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001384409.1NP_001371338.1  WD repeat-containing protein 5 isoform 1

    Status: REVIEWED

    Source sequence(s)
    BX649632
    Conserved Domains (2) summary
    cd00200
    Location:37331
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:4885
    7WD40; WD40 repeat [structural motif]
  2. NM_001384410.1NP_001371339.1  WD repeat-containing protein 5 isoform 1

    Status: REVIEWED

    Source sequence(s)
    BX649632
    Conserved Domains (2) summary
    cd00200
    Location:37331
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:4885
    7WD40; WD40 repeat [structural motif]
  3. NM_001384411.1NP_001371340.1  WD repeat-containing protein 5 isoform 1

    Status: REVIEWED

    Source sequence(s)
    BX649632
    Conserved Domains (2) summary
    cd00200
    Location:37331
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:4885
    7WD40; WD40 repeat [structural motif]
  4. NM_001384412.1NP_001371341.1  WD repeat-containing protein 5 isoform 1

    Status: REVIEWED

    Source sequence(s)
    BX649632
    Conserved Domains (2) summary
    cd00200
    Location:37331
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:4885
    7WD40; WD40 repeat [structural motif]
  5. NM_001384413.1NP_001371342.1  WD repeat-containing protein 5 isoform 1

    Status: REVIEWED

    Source sequence(s)
    BX649632
    Conserved Domains (2) summary
    cd00200
    Location:37331
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:4885
    7WD40; WD40 repeat [structural motif]
  6. NM_001384414.1NP_001371343.1  WD repeat-containing protein 5 isoform 1

    Status: REVIEWED

    Source sequence(s)
    BX649632
    Conserved Domains (2) summary
    cd00200
    Location:37331
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:4885
    7WD40; WD40 repeat [structural motif]
  7. NM_001384415.1NP_001371344.1  WD repeat-containing protein 5 isoform 1

    Status: REVIEWED

    Source sequence(s)
    BX649632
    Conserved Domains (2) summary
    cd00200
    Location:37331
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:4885
    7WD40; WD40 repeat [structural motif]
  8. NM_001384416.1NP_001371345.1  WD repeat-containing protein 5 isoform 2

    Status: REVIEWED

    Source sequence(s)
    BX649632
    Conserved Domains (2) summary
    cd00200
    Location:37330
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:4885
    7WD40; WD40 repeat [structural motif]
  9. NM_001384417.1NP_001371346.1  WD repeat-containing protein 5 isoform 3

    Status: REVIEWED

    Source sequence(s)
    BX649632
    Conserved Domains (2) summary
    cd00200
    Location:37328
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:4885
    7WD40; WD40 repeat [structural motif]
  10. NM_001384418.1NP_001371347.1  WD repeat-containing protein 5 isoform 4

    Status: REVIEWED

    Source sequence(s)
    BX649632
    Conserved Domains (2) summary
    cd00200
    Location:37288
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:4984
    7WD40; WD40 repeat [structural motif]
  11. NM_001384419.1NP_001371348.1  WD repeat-containing protein 5 isoform 4

    Status: REVIEWED

    Source sequence(s)
    BX649632
    Conserved Domains (2) summary
    cd00200
    Location:37288
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:4984
    7WD40; WD40 repeat [structural motif]
  12. NM_017588.3NP_060058.1  WD repeat-containing protein 5 isoform 1

    See identical proteins and their annotated locations for NP_060058.1

    Status: REVIEWED

    Source sequence(s)
    AA490313, AK000552, BC029769, BG773451, BX649632
    Consensus CDS
    CCDS6981.1
    UniProtKB/Swiss-Prot
    P61964
    Related
    ENSP00000351446.3, ENST00000358625.4
    Conserved Domains (2) summary
    cd00200
    Location:37331
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:4885
    7WD40; WD40 repeat [structural motif]
  13. NM_052821.4NP_438172.1  WD repeat-containing protein 5 isoform 1

    See identical proteins and their annotated locations for NP_438172.1

    Status: REVIEWED

    Source sequence(s)
    BX649632
    Consensus CDS
    CCDS6981.1
    UniProtKB/Swiss-Prot
    P61964
    Conserved Domains (2) summary
    cd00200
    Location:37331
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:4885
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    134135199..134159968
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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