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TRIM31 tripartite motif containing 31 [ Homo sapiens (human) ]

Gene ID: 11074, updated on 10-Oct-2024

Summary

Official Symbol
TRIM31provided by HGNC
Official Full Name
tripartite motif containing 31provided by HGNC
Primary source
HGNC:HGNC:16289
See related
Ensembl:ENSG00000204616 MIM:609316; AllianceGenome:HGNC:16289
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNF; HCG1; HCGI; C6orf13
Summary
This gene encodes a protein that functions as an E3 ubiquitin-protein ligase. This gene shows altered expression in certain tumors and may be a negative regulator of cell growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Expression
Biased expression in colon (RPKM 26.2), urinary bladder (RPKM 20.1) and 5 other tissues See more
Orthologs
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Genomic context

See TRIM31 in Genome Data Viewer
Location:
6p22.1
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (30102897..30113090, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (29967171..29977357, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (30070674..30080867, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene POLR1H antisense, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:30028069-30028935 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:30028936-30029801 Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 11 Neighboring gene RNA polymerase I subunit H Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:30041647-30042322 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:30042323-30042996 Neighboring gene ring finger protein 39 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:30068196-30068705 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:30070193-30070692 Neighboring gene TRIM31 antisense RNA 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:30080310-30081509 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene tripartite motif containing 40

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer.
EBI GWAS Catalog
Common genetic variation and performance on standardized cognitive tests.
EBI GWAS Catalog
Genome-wide association study identified the human leukocyte antigen region as a novel locus for plasma beta-2 microglobulin.
EBI GWAS Catalog
Genome-wide association study of proneness to anger.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag HIV-1 infection is modestly restricted by human TRIM31. Gene silencing of endogenously expressed TRIM31inhibits viral release, suggesting the interaction between HIV-1 Gag and TRIM31 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in antiviral innate immune response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in defense response to virus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of NLRP3 inflammasome complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of viral entry into host cell IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of viral entry into host cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of viral transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in protein K48-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein K63-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in viral release from host cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase TRIM31
Names
RING-type E3 ubiquitin transferase TRIM31
tripartite motif-containing protein 31
NP_008959.3
XP_011512566.1
XP_011512567.1
XP_011512568.1
XP_047274066.1
XP_054185701.1
XP_054185702.1
XP_054185703.1
XP_054186198.1
XP_054186199.1
XP_054186200.1
XP_054186201.1
XP_054186486.1
XP_054186487.1
XP_054186488.1
XP_054186489.1
XP_054186736.1
XP_054186970.1
XP_054186971.1
XP_054186972.1
XP_054186973.1
XP_054187250.1
XP_054210066.1
XP_054210067.1
XP_054210068.1
XP_054210069.1
XP_054210070.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007028.5NP_008959.3  E3 ubiquitin-protein ligase TRIM31

    See identical proteins and their annotated locations for NP_008959.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as alpha) represents the longest transcript and encodes the protein.
    Source sequence(s)
    AF230386, BG403536, BM847963, CB142265
    Consensus CDS
    CCDS34374.1
    UniProtKB/Swiss-Prot
    A6NLX6, A9R9Q4, Q53H52, Q5RI37, Q5SRJ7, Q5SRJ8, Q5SS28, Q96AK4, Q96AP8, Q99579, Q9BZY8, Q9BZY9
    UniProtKB/TrEMBL
    A0A1U9X8Q7, A0A1U9X8R1, A0A1U9X8S0, A0A1U9X8S1, A0A1U9X8T0, Q2L6J1
    Related
    ENSP00000365924.3, ENST00000376734.4
    Conserved Domains (2) summary
    smart00336
    Location:90131
    BBOX; B-Box-type zinc finger
    cd16582
    Location:1356
    RING-HC_TRIM31_C-V; RING finger, HC subclass, found in tripartite motif-containing protein 31 (TRIM31) and similar proteins

RNA

  1. NR_134870.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate segment in the 3' region compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK222729, CB142265, DB244000
  2. NR_134871.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as beta) lacks an exon and uses an alternate splice site compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF230387, CB142265, DB244000

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    30102897..30113090 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047418110.1XP_047274066.1  E3 ubiquitin-protein ligase TRIM31 isoform X3

  2. XM_011514264.2XP_011512566.1  E3 ubiquitin-protein ligase TRIM31 isoform X1

    See identical proteins and their annotated locations for XP_011512566.1

    UniProtKB/TrEMBL
    A0A1U9X8R1, A0A1U9X8S0, A0A1U9X8S1, A0A1U9X8T0
    Conserved Domains (2) summary
    smart00336
    Location:90131
    BBOX; B-Box-type zinc finger
    pfam15227
    Location:1656
    zf-C3HC4_4; zinc finger of C3HC4-type, RING
  3. XM_011514265.2XP_011512567.1  E3 ubiquitin-protein ligase TRIM31 isoform X2

    See identical proteins and their annotated locations for XP_011512567.1

    UniProtKB/TrEMBL
    A0A1U9X8R1
    Conserved Domains (2) summary
    smart00336
    Location:90131
    BBOX; B-Box-type zinc finger
    pfam15227
    Location:1656
    zf-C3HC4_4; zinc finger of C3HC4-type, RING
  4. XM_011514266.1XP_011512568.1  E3 ubiquitin-protein ligase TRIM31 isoform X4

    See identical proteins and their annotated locations for XP_011512568.1

    UniProtKB/TrEMBL
    A0A140T9J6
    Conserved Domains (2) summary
    smart00336
    Location:90131
    BBOX; B-Box-type zinc finger
    pfam15227
    Location:1656
    zf-C3HC4_4; zinc finger of C3HC4-type, RING

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_167244.2 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    1368493..1371180 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p14 ALT_REF_LOCI_2

    Range
    1582690..1592889 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054329726.1XP_054185701.1  E3 ubiquitin-protein ligase TRIM31 isoform X1

  2. XM_054329727.1XP_054185702.1  E3 ubiquitin-protein ligase TRIM31 isoform X2

  3. XM_054329728.1XP_054185703.1  E3 ubiquitin-protein ligase TRIM31 isoform X4

Reference GRCh38.p14 ALT_REF_LOCI_3

Genomic

  1. NT_167245.2 Reference GRCh38.p14 ALT_REF_LOCI_3

    Range
    1358814..1369000 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054330225.1XP_054186200.1  E3 ubiquitin-protein ligase TRIM31 isoform X3

  2. XM_054330223.1XP_054186198.1  E3 ubiquitin-protein ligase TRIM31 isoform X1

  3. XM_054330224.1XP_054186199.1  E3 ubiquitin-protein ligase TRIM31 isoform X2

  4. XM_054330226.1XP_054186201.1  E3 ubiquitin-protein ligase TRIM31 isoform X4

RNA

  1. XR_008485692.1 RNA Sequence

Reference GRCh38.p14 ALT_REF_LOCI_4

Genomic

  1. NT_167246.2 Reference GRCh38.p14 ALT_REF_LOCI_4

    Range
    1363614..1373800 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054330513.1XP_054186488.1  E3 ubiquitin-protein ligase TRIM31 isoform X3

  2. XM_054330511.1XP_054186486.1  E3 ubiquitin-protein ligase TRIM31 isoform X1

  3. XM_054330512.1XP_054186487.1  E3 ubiquitin-protein ligase TRIM31 isoform X2

  4. XM_054330514.1XP_054186489.1  E3 ubiquitin-protein ligase TRIM31 isoform X4

RNA

  1. XR_008485697.1 RNA Sequence

Reference GRCh38.p14 ALT_REF_LOCI_5

Genomic

  1. NT_167247.2 Reference GRCh38.p14 ALT_REF_LOCI_5

    Range
    1446972..1457163 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054330761.1XP_054186736.1  E3 ubiquitin-protein ligase TRIM31 isoform X2

RNA

  1. XR_008485703.1 RNA Sequence

Reference GRCh38.p14 ALT_REF_LOCI_6

Genomic

  1. NT_167248.2 Reference GRCh38.p14 ALT_REF_LOCI_6

    Range
    1358044..1368231 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054330997.1XP_054186972.1  E3 ubiquitin-protein ligase TRIM31 isoform X3

  2. XM_054330995.1XP_054186970.1  E3 ubiquitin-protein ligase TRIM31 isoform X1

  3. XM_054330996.1XP_054186971.1  E3 ubiquitin-protein ligase TRIM31 isoform X2

  4. XM_054330998.1XP_054186973.1  E3 ubiquitin-protein ligase TRIM31 isoform X4

RNA

  1. XR_008485709.1 RNA Sequence

Reference GRCh38.p14 ALT_REF_LOCI_7

Genomic

  1. NT_167249.2 Reference GRCh38.p14 ALT_REF_LOCI_7

    Range
    1401829..1412013 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054331275.1XP_054187250.1  E3 ubiquitin-protein ligase TRIM31 isoform X2

RNA

  1. XR_008485714.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    29967171..29977357 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054354093.1XP_054210068.1  E3 ubiquitin-protein ligase TRIM31 isoform X3

  2. XM_054354091.1XP_054210066.1  E3 ubiquitin-protein ligase TRIM31 isoform X1

  3. XM_054354092.1XP_054210067.1  E3 ubiquitin-protein ligase TRIM31 isoform X2

  4. XM_054354094.1XP_054210069.1  E3 ubiquitin-protein ligase TRIM31 isoform X5

  5. XM_054354095.1XP_054210070.1  E3 ubiquitin-protein ligase TRIM31 isoform X4