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TRIM31 tripartite motif containing 31 [ Homo sapiens (human) ]

Gene ID: 11074, updated on 6-Jan-2019

Summary

Official Symbol
TRIM31provided by HGNC
Official Full Name
tripartite motif containing 31provided by HGNC
Primary source
HGNC:HGNC:16289
See related
Ensembl:ENSG00000204616 MIM:609316
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNF; HCG1; HCGI; C6orf13
Summary
This gene encodes a protein that functions as an E3 ubiquitin-protein ligase. This gene shows altered expression in certain tumors and may be a negative regulator of cell growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Expression
Biased expression in colon (RPKM 26.2), urinary bladder (RPKM 20.1) and 5 other tissues See more
Orthologs

Genomic context

See TRIM31 in Genome Data Viewer
Location:
6p22.1
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (30102892..30113106, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (30070674..30080867, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene zinc ribbon domain containing 1 Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 11 Neighboring gene ring finger protein 39 Neighboring gene TRIM31 antisense RNA 1 Neighboring gene tripartite motif containing 40 Neighboring gene tripartite motif containing 10 Neighboring gene tripartite motif containing 15

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer.
NHGRI GWA Catalog
Common genetic variation and performance on standardized cognitive tests.
NHGRI GWA Catalog
Genome-wide association study identified the human leukocyte antigen region as a novel locus for plasma beta-2 microglobulin.
NHGRI GWA Catalog
Genome-wide association study of proneness to anger.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag HIV-1 infection is modestly restricted by human TRIM31. Gene silencing of endogenously expressed TRIM31inhibits viral release, suggesting the interaction between HIV-1 Gag and TRIM31 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Interferon Signaling, organism-specific biosystem (from REACTOME)
    Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
  • Interferon gamma signaling, organism-specific biosystem (from REACTOME)
    Interferon gamma signaling, organism-specific biosystemInterferon-gamma (IFN-gamma) belongs to the type II interferon family and is secreted by activated immune cells-primarily T and NK cells, but also B-cells and APC. INFG exerts its effect on cells by ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
interferon-gamma-mediated signaling pathway TAS
Traceable Author Statement
more info
 
negative regulation of viral entry into host cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of viral transcription IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
regulation of viral release from host cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase TRIM31
Names
RING-type E3 ubiquitin transferase TRIM31
tripartite motif-containing protein 31
NP_008959.3
XP_011512566.1
XP_011512567.1
XP_011512568.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007028.5NP_008959.3  E3 ubiquitin-protein ligase TRIM31

    See identical proteins and their annotated locations for NP_008959.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as alpha) represents the longest transcript and encodes the protein.
    Source sequence(s)
    AF230386, BG403536, BM847963, CB142265
    Consensus CDS
    CCDS34374.1
    UniProtKB/Swiss-Prot
    Q9BZY9
    UniProtKB/TrEMBL
    Q2L6J1
    Related
    ENSP00000365924.3, ENST00000376734.3
    Conserved Domains (2) summary
    smart00336
    Location:90131
    BBOX; B-Box-type zinc finger
    cd16582
    Location:1356
    RING-HC_TRIM31_C-V; RING finger, HC subclass, found in tripartite motif-containing protein 31 (TRIM31) and similar proteins

RNA

  1. NR_134870.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate segment in the 3' region compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK222729, BG403536, CB142265, DB244000
  2. NR_134871.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as beta) lacks an exon and uses an alternate splice site compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF230387, BG403536, CB142265, DB244000

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

    Range
    30102892..30113106 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514264.1XP_011512566.1  E3 ubiquitin-protein ligase TRIM31 isoform X1

    See identical proteins and their annotated locations for XP_011512566.1

    Conserved Domains (2) summary
    smart00336
    Location:90131
    BBOX; B-Box-type zinc finger
    pfam15227
    Location:1656
    zf-C3HC4_4; zinc finger of C3HC4-type, RING
  2. XM_011514265.1XP_011512567.1  E3 ubiquitin-protein ligase TRIM31 isoform X2

    See identical proteins and their annotated locations for XP_011512567.1

    Conserved Domains (2) summary
    smart00336
    Location:90131
    BBOX; B-Box-type zinc finger
    pfam15227
    Location:1656
    zf-C3HC4_4; zinc finger of C3HC4-type, RING
  3. XM_011514266.1XP_011512568.1  E3 ubiquitin-protein ligase TRIM31 isoform X3

    See identical proteins and their annotated locations for XP_011512568.1

    Conserved Domains (2) summary
    smart00336
    Location:90131
    BBOX; B-Box-type zinc finger
    pfam15227
    Location:1656
    zf-C3HC4_4; zinc finger of C3HC4-type, RING

Reference GRCh38.p12 ALT_REF_LOCI_1

Genomic

  1. NT_167244.2 Reference GRCh38.p12 ALT_REF_LOCI_1

    Range
    1368493..1371196 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p12 ALT_REF_LOCI_2

    Range
    1582690..1592905 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_3

Genomic

  1. NT_167245.2 Reference GRCh38.p12 ALT_REF_LOCI_3

    Range
    1358814..1369016 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_4

Genomic

  1. NT_167246.2 Reference GRCh38.p12 ALT_REF_LOCI_4

    Range
    1363614..1373816 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_5

Genomic

  1. NT_167247.2 Reference GRCh38.p12 ALT_REF_LOCI_5

    Range
    1446972..1457179 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_6

Genomic

  1. NT_167248.2 Reference GRCh38.p12 ALT_REF_LOCI_6

    Range
    1358044..1368247 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_7

Genomic

  1. NT_167249.2 Reference GRCh38.p12 ALT_REF_LOCI_7

    Range
    1401829..1412029 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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