U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Fntb farnesyltransferase, CAAX box, beta [ Mus musculus (house mouse) ]

Gene ID: 110606, updated on 11-Apr-2024

Summary

Official Symbol
Fntbprovided by MGI
Official Full Name
farnesyltransferase, CAAX box, betaprovided by MGI
Primary source
MGI:MGI:1861305
See related
Ensembl:ENSMUSG00000033373 AllianceGenome:MGI:1861305
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2010013E13Rik
Summary
Enables farnesyltranstransferase activity. Acts upstream of or within negative regulation of cell population proliferation; positive regulation of fibroblast proliferation; and wound healing. Predicted to be part of microtubule associated complex and protein farnesyltransferase complex. Orthologous to several human genes including CHURC1-FNTB (CHURC1-FNTB readthrough). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 14.1), limb E14.5 (RPKM 12.8) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Location:
12 C3; 12 33.73 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (76884014..76968188)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (76837400..76921412)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene glutathione peroxidase 2 Neighboring gene RAB15, member RAS oncogene family Neighboring gene STARR-seq mESC enhancer starr_32534 Neighboring gene predicted gene, 34988 Neighboring gene STARR-positive B cell enhancer ABC_E2389 Neighboring gene predicted gene, 46357 Neighboring gene predicted gene, 46358 Neighboring gene STARR-seq mESC enhancer starr_32542 Neighboring gene STARR-positive B cell enhancer ABC_E3056 Neighboring gene STARR-seq mESC enhancer starr_32548 Neighboring gene Max protein Neighboring gene predicted gene, 35041

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables farnesyltranstransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to peptide binding ISO
Inferred from Sequence Orthology
more info
 
enables prenyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to protein farnesyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to protein farnesyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein farnesyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein prenyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of fibroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of fibroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of nitric-oxide synthase biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein farnesylation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of fibroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to cytokine ISO
Inferred from Sequence Orthology
more info
 
involved_in response to inorganic substance ISO
Inferred from Sequence Orthology
more info
 
involved_in response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within wound healing IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of microtubule associated complex ISO
Inferred from Sequence Orthology
more info
 
part_of protein farnesyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of protein farnesyltransferase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein farnesyltransferase subunit beta
Names
CAAX farnesyltransferase subunit beta
FTase-beta
ras proteins prenyltransferase subunit beta
NP_001405090.1
NP_001405091.1
NP_666039.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418161.1NP_001405090.1  protein farnesyltransferase subunit beta isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC124556, AC132331
  2. NM_001418162.1NP_001405091.1  protein farnesyltransferase subunit beta isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC124556
  3. NM_145927.3NP_666039.1  protein farnesyltransferase subunit beta isoform 1

    See identical proteins and their annotated locations for NP_666039.1

    Status: VALIDATED

    Source sequence(s)
    AC124556, AC132331
    Consensus CDS
    CCDS25998.1
    UniProtKB/Swiss-Prot
    Q8K2I1
    UniProtKB/TrEMBL
    D3YWJ4
    Related
    ENSMUSP00000035498.10, ENSMUST00000041008.10
    Conserved Domains (2) summary
    PLN02710
    Location:42419
    PLN02710; farnesyltranstransferase subunit beta
    cd02893
    Location:75373
    FTase; Protein farnesyltransferase (FTase)_like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). FTases are a subgroup of PTase family of lipid-modifying enzymes. PTases catalyze the ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    76884014..76968188
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001780410.3 RNA Sequence