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FNTB farnesyltransferase, CAAX box, beta [ Homo sapiens (human) ]

Gene ID: 2342, updated on 3-Jan-2019

Summary

Official Symbol
FNTBprovided by HGNC
Official Full Name
farnesyltransferase, CAAX box, betaprovided by HGNC
Primary source
HGNC:HGNC:3785
See related
Ensembl:ENSG00000257365 MIM:134636
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FPTB
Expression
Ubiquitous expression in testis (RPKM 9.3), brain (RPKM 8.2) and 25 other tissues See more
Orthologs

Genomic context

See FNTB in Genome Data Viewer
Location:
14q23.3
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (64986789..65062652)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (65453507..65529370)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene CHURC1-FNTB readthrough Neighboring gene glutathione peroxidase 2 Neighboring gene RAB15, member RAS oncogene family Neighboring gene uncharacterized LOC107984655 Neighboring gene MYC associated factor X Neighboring gene microRNA 4706 Neighboring gene uncharacterized LOC100506321 Neighboring gene RNA, U2 small nuclear 14, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies loci affecting blood copper, selenium and zinc.
NHGRI GWA Catalog
Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium.
NHGRI GWA Catalog
Seventy-five genetic loci influencing the human red blood cell.
NHGRI GWA Catalog

Pathways from BioSystems

  • Inactivation, recovery and regulation of the phototransduction cascade, organism-specific biosystem (from REACTOME)
    Inactivation, recovery and regulation of the phototransduction cascade, organism-specific biosystemTo terminate the single photon response and restore the system to its basal state, the three activated intermediates in phototransduction, rhodopsin (MII), transducin alpha subunit with GTP bound (GN...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Terpenoid backbone biosynthesis, organism-specific biosystem (from KEGG)
    Terpenoid backbone biosynthesis, organism-specific biosystemTerpenoids, also known as isoprenoids, are a large class of natural products consisting of isoprene (C5) units. There are two biosynthetic pathways, the mevalonate pathway [MD:M00095] and the non-mev...
  • Terpenoid backbone biosynthesis, conserved biosystem (from KEGG)
    Terpenoid backbone biosynthesis, conserved biosystemTerpenoids, also known as isoprenoids, are a large class of natural products consisting of isoprene (C5) units. There are two biosynthetic pathways, the mevalonate pathway [MD:M00095] and the non-mev...
  • The phototransduction cascade, organism-specific biosystem (from REACTOME)
    The phototransduction cascade, organism-specific biosystemThe visual pigment (rhodopsin in rods) consists of an 11-cis-retinal (11cRAL) chromophore covalently attached to a GPCR opsin family member via a Schiff base linkage. Upon photon absorption, 11cRAL i...
  • Visual phototransduction, organism-specific biosystem (from REACTOME)
    Visual phototransduction, organism-specific biosystemVisual phototransduction is the process by which photon absorption by visual pigment molecules in photoreceptor cells is converted to an electrical cellular response. The events in this process are p...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough CHURC1-FNTB

Readthrough gene: CHURC1-FNTB, Included gene: CHURC1

Homology

Clone Names

  • MGC31935

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to protein farnesyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein farnesyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to protein farnesyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
protein farnesylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein farnesylation IDA
Inferred from Direct Assay
more info
PubMed 
protein prenylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
microtubule associated complex IDA
Inferred from Direct Assay
more info
PubMed 
protein farnesyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein farnesyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein farnesyltransferase subunit beta
Names
CAAX farnesyltransferase subunit beta
FTase-beta
epididymis secretory sperm binding protein
ras proteins prenyltransferase subunit beta
NP_002019.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002028.4NP_002019.1  protein farnesyltransferase subunit beta

    See identical proteins and their annotated locations for NP_002019.1

    Status: VALIDATED

    Source sequence(s)
    AU122768, BC013574, BC020232
    Consensus CDS
    CCDS9769.1
    UniProtKB/Swiss-Prot
    P49356
    Related
    ENSP00000246166.2, ENST00000246166.2
    Conserved Domains (1) summary
    cd02893
    Location:75373
    FTase; Protein farnesyltransferase (FTase)_like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). FTases are a subgroup of PTase family of lipid-modifying enzymes. PTases catalyze the ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

    Range
    64986789..65062652
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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