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ZPBP zona pellucida binding protein [ Homo sapiens (human) ]

Gene ID: 11055, updated on 7-Jun-2020

Summary

Official Symbol
ZPBPprovided by HGNC
Official Full Name
zona pellucida binding proteinprovided by HGNC
Primary source
HGNC:HGNC:15662
See related
Ensembl:ENSG00000042813 MIM:608498
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZPBP1
Summary
ZPBP is one of several proteins that are thought to participate in secondary binding between acrosome-reacted sperm and the egg-specific extracellular matrix, the zona pellucida (McLeskey et al., 1998 [PubMed 9378618]).[supplied by OMIM, Aug 2008]
Expression
Restricted expression toward testis (RPKM 37.4) See more
Orthologs

Genomic context

See ZPBP in Genome Data Viewer
Location:
7p12.2
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (49846355..50093258, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (49977023..50132860, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene cell division cycle 14C Neighboring gene DEAD-box helicase 43 pseudogene 2 Neighboring gene von Willebrand factor C domain containing 2 Neighboring gene G protein nucleolar 2 pseudogene 1 Neighboring gene spermatogenesis associated 48 Neighboring gene conserved acetylation island sequence 3 enhancer Neighboring gene IKAROS family zinc finger 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease.
NHGRI GWA Catalog
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
NHGRI GWA Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ93221

Gene Ontology Provided by GOA

Process Evidence Code Pubs
acrosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
binding of sperm to zona pellucida IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
acrosomal membrane IEA
Inferred from Electronic Annotation
more info
 
acrosomal vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
nucleus HDA PubMed 
zona pellucida receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zona pellucida-binding protein 1
Names
inner acrosomal membrane IAM38

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159878.2NP_001153350.1  zona pellucida-binding protein 1 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
    Source sequence(s)
    AC034148, AI207093, AK312799
    Consensus CDS
    CCDS55110.1
    UniProtKB/Swiss-Prot
    Q9BS86
    Related
    ENSP00000402071.1, ENST00000419417.5
    Conserved Domains (2) summary
    pfam07354
    Location:86350
    Sp38; Zona-pellucida-binding protein (Sp38)
    smart00410
    Location:97142
    IG_like; Immunoglobulin like
  2. NM_007009.3NP_008940.2  zona pellucida-binding protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_008940.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC034148, AI207093, BC005223
    Consensus CDS
    CCDS5509.1
    UniProtKB/Swiss-Prot
    Q9BS86
    Related
    ENSP00000046087.2, ENST00000046087.7
    Conserved Domains (2) summary
    pfam07354
    Location:86351
    Sp38; Zona-pellucida-binding protein (Sp38)
    smart00410
    Location:97143
    IG_like; Immunoglobulin like

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    49846355..50093258 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515097.1XP_011513399.1  zona pellucida-binding protein 1 isoform X4

    Conserved Domains (2) summary
    pfam07354
    Location:86322
    Sp38; Zona-pellucida-binding protein (Sp38)
    smart00410
    Location:97143
    IG_like; Immunoglobulin like
  2. XM_017011707.1XP_016867196.1  zona pellucida-binding protein 1 isoform X3

  3. XM_011515101.3XP_011513403.1  zona pellucida-binding protein 1 isoform X6

    Conserved Domains (1) summary
    pfam07354
    Location:86271
    Sp38; Zona-pellucida-binding protein (Sp38)
  4. XM_011515100.2XP_011513402.1  zona pellucida-binding protein 1 isoform X5

    Conserved Domains (1) summary
    pfam07354
    Location:71280
    Sp38; Zona-pellucida-binding protein (Sp38)
  5. XM_011515095.2XP_011513397.1  zona pellucida-binding protein 1 isoform X1

    Conserved Domains (2) summary
    pfam07354
    Location:86322
    Sp38; Zona-pellucida-binding protein (Sp38)
    smart00410
    Location:97143
    IG_like; Immunoglobulin like
  6. XM_011515096.2XP_011513398.1  zona pellucida-binding protein 1 isoform X2

    Conserved Domains (2) summary
    pfam07354
    Location:86321
    Sp38; Zona-pellucida-binding protein (Sp38)
    smart00410
    Location:97142
    IG_like; Immunoglobulin like
  7. XM_011515102.2XP_011513404.1  zona pellucida-binding protein 1 isoform X8

    Conserved Domains (2) summary
    pfam07354
    Location:12248
    Sp38; Zona-pellucida-binding protein (Sp38)
    smart00410
    Location:2369
    IG_like; Immunoglobulin like
  8. XM_024446646.1XP_024302414.1  zona pellucida-binding protein 1 isoform X9

    Conserved Domains (1) summary
    pfam07354
    Location:12276
    Sp38; Zona-pellucida-binding protein (Sp38)
  9. XM_024446645.1XP_024302413.1  zona pellucida-binding protein 1 isoform X7

    Conserved Domains (1) summary
    pfam07354
    Location:86300
    Sp38; Zona-pellucida-binding protein (Sp38)
  10. XM_011515103.1XP_011513405.1  zona pellucida-binding protein 1 isoform X10

    Conserved Domains (2) summary
    pfam07354
    Location:86258
    Sp38; Zona-pellucida-binding protein (Sp38)
    smart00410
    Location:97143
    IG_like; Immunoglobulin like

RNA

  1. XR_001744543.1 RNA Sequence

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