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OGFR opioid growth factor receptor [ Homo sapiens (human) ]

Gene ID: 11054, updated on 5-Aug-2018

Summary

Official Symbol
OGFRprovided by HGNC
Official Full Name
opioid growth factor receptorprovided by HGNC
Primary source
HGNC:HGNC:15768
See related
Ensembl:ENSG00000060491 MIM:606459; Vega:OTTHUMG00000032937
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a receptor for opioid growth factor (OGF), also known as [Met(5)]-enkephalin. OGF is a negative regulator of cell proliferation and tissue organization in a variety of processes. The encoded unbound receptor for OGF has been localized to the outer nuclear envelope, where it binds OGF and is translocated into the nucleus. The coding sequence of this gene contains a polymorphic region of 60 nt tandem imperfect repeat units. Several transcripts containing between zero and eight repeat units have been reported. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in spleen (RPKM 22.4), lung (RPKM 12.6) and 25 other tissues See more
Orthologs

Genomic context

See OGFR in Genome Data Viewer
Location:
20q13.33
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 20 NC_000020.11 (62804800..62814000)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (61436156..61445352)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372716 Neighboring gene MRG domain binding protein Neighboring gene OGFR antisense RNA 1 Neighboring gene collagen type IX alpha 3 chain Neighboring gene transcription factor like 5 Neighboring gene diphthamide biosynthesis 3 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
opioid receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
opioid receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
regulation of cell growth NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
opioid growth factor receptor
Names
protein 7-60
zeta-type opioid receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033957.1 RefSeqGene

    Range
    4976..14176
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_007346.3NP_031372.2  opioid growth factor receptor

    See identical proteins and their annotated locations for NP_031372.2

    Status: REVIEWED

    Source sequence(s)
    AF172453, AL035669
    Consensus CDS
    CCDS13504.1
    UniProtKB/Swiss-Prot
    Q9NZT2
    Related
    ENSP00000290291.6, OTTHUMP00000031503, ENST00000290291.10, OTTHUMT00000080067
    Conserved Domains (2) summary
    pfam04664
    Location:86293
    OGFr_N; Opioid growth factor receptor (OGFr) conserved region
    pfam15250
    Location:537649
    Raftlin; Raftlin

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p12 Primary Assembly

    Range
    62804800..62814000
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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