Format

Send to:

Choose Destination

ADRM1 adhesion regulating molecule 1 [ Homo sapiens (human) ]

Gene ID: 11047, updated on 6-Jan-2019

Summary

Official Symbol
ADRM1provided by HGNC
Official Full Name
adhesion regulating molecule 1provided by HGNC
Primary source
HGNC:HGNC:15759
See related
Ensembl:ENSG00000130706 MIM:610650
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARM1; ARM-1; GP110
Summary
This gene encodes a member of the adhesion regulating molecule 1 protein family. The encoded protein is a component of the proteasome where it acts as a ubiquitin receptor and recruits the deubiquitinating enzyme, ubiquitin carboxyl-terminal hydrolase L5. Increased levels of the encoded protein are associated with increased cell adhesion, which is likely an indirect effect of this intracellular protein. Dysregulation of this gene has been implicated in carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Expression
Ubiquitous expression in testis (RPKM 31.4), fat (RPKM 17.5) and 25 other tissues See more
Orthologs

Genomic context

See ADRM1 in Genome Data Viewer
Location:
20q13.33
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 20 NC_000020.11 (62302061..62308862)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (60877112..60884206)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene putative uncharacterized protein FLJ44790 Neighboring gene oxysterol binding protein like 2 Neighboring gene uncharacterized LOC105372707 Neighboring gene laminin subunit alpha 5 Neighboring gene microRNA 4758 Neighboring gene LAMA5 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
NHGRI GWA Catalog

Pathways from BioSystems

  • Deubiquitination, organism-specific biosystem (from REACTOME)
    Deubiquitination, organism-specific biosystemUbiquitination, the modification of proteins by the covalent attachment of ubiquitin (Ub), is a key regulatory mechanism for many many cellular processes, including protein degradation by the 26S pro...
  • Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
    Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
  • Epstein-Barr virus infection, conserved biosystem (from KEGG)
    Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
  • Proteasome, organism-specific biosystem (from KEGG)
    Proteasome, organism-specific biosystemThe proteasome is a protein-destroying apparatus involved in many essential cellular functions, such as regulation of cell cycle, cell differentiation, signal transduction pathways, antigen processin...
  • Proteasome, conserved biosystem (from KEGG)
    Proteasome, conserved biosystemThe proteasome is a protein-destroying apparatus involved in many essential cellular functions, such as regulation of cell cycle, cell differentiation, signal transduction pathways, antigen processin...
  • Proteasome, 19S regulatory particle (PA700), organism-specific biosystem (from KEGG)
    Proteasome, 19S regulatory particle (PA700), organism-specific biosystemStructural complex; Genetic information processing; Proteasome
  • Proteasome, 19S regulatory particle (PA700), conserved biosystem (from KEGG)
    Proteasome, 19S regulatory particle (PA700), conserved biosystemStructural complex; Genetic information processing; Proteasome
  • UCH proteinases, organism-specific biosystem (from REACTOME)
    UCH proteinases, organism-specific biosystemDUBs of the Ub C-terminal Hydrolase (UCH) family are thiol proteases that have an N-terminal catalytic domain sometimes followed by C-terminal extensions that mediate protein-protein interactions. Hu...
  • Ub-specific processing proteases, organism-specific biosystem (from REACTOME)
    Ub-specific processing proteases, organism-specific biosystemUb-specific processing proteases (USPs) are the largest of the DUB families with more than 50 members in humans. The USP catalytic domain varies considerably in size and consists of six conserved mo...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC29536

Gene Ontology Provided by GOA

Function Evidence Code Pubs
endopeptidase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endopeptidase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
proteasome binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteasome binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
positive regulation of endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
proteasome assembly IDA
Inferred from Direct Assay
more info
PubMed 
protein deubiquitination TAS
Traceable Author Statement
more info
 
transcription elongation from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
proteasome complex IDA
Inferred from Direct Assay
more info
PubMed 
proteasome regulatory particle, lid subcomplex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
proteasomal ubiquitin receptor ADRM1
Names
110 kDa cell membrane glycoprotein
M(r) 110,000 surface antigen
proteasome regulatory particle non-ATPase 13
rpn13 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050661.1 RefSeqGene

    Range
    5841..11807
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001281437.1NP_001268366.1  proteasomal ubiquitin receptor ADRM1 isoform 2

    See identical proteins and their annotated locations for NP_001268366.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1. Variants 3 and 4 encode the same isoform.
    Source sequence(s)
    BC017245, BR000321, HY029018, HY178253
    Consensus CDS
    CCDS74747.1
    UniProtKB/Swiss-Prot
    Q16186
    UniProtKB/TrEMBL
    A0A087WX59
    Conserved Domains (2) summary
    pfam16550
    Location:235342
    RPN13_C; UCH-binding domain
    cl17171
    Location:2489
    PH-like; Pleckstrin homology-like domain
  2. NM_001281438.1NP_001268367.1  proteasomal ubiquitin receptor ADRM1 isoform 2

    See identical proteins and their annotated locations for NP_001268367.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1. Variants 3 and 4 encode the same isoform.
    Source sequence(s)
    BC017245, BG337785, BR000321, HY029018
    Consensus CDS
    CCDS74747.1
    UniProtKB/Swiss-Prot
    Q16186
    UniProtKB/TrEMBL
    A0A087WX59
    Related
    ENSP00000480756.1, ENST00000620230.4
    Conserved Domains (2) summary
    pfam16550
    Location:235342
    RPN13_C; UCH-binding domain
    cl17171
    Location:2489
    PH-like; Pleckstrin homology-like domain
  3. NM_007002.4NP_008933.2  proteasomal ubiquitin receptor ADRM1 isoform 1

    See identical proteins and their annotated locations for NP_008933.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AL354836
    Consensus CDS
    CCDS13496.1
    UniProtKB/Swiss-Prot
    Q16186
    Related
    ENSP00000253003.2, ENST00000253003.6
    Conserved Domains (2) summary
    cd13314
    Location:24128
    PH_Rpn13; Pleckstrin homology-like domain of Regulatory Particle Non-ATPase 13
    pfam16550
    Location:274381
    RPN13_C; UCH-binding domain
  4. NM_175573.2NP_783163.1  proteasomal ubiquitin receptor ADRM1 isoform 1

    See identical proteins and their annotated locations for NP_783163.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    BC017245, BR000321, HY029018
    Consensus CDS
    CCDS13496.1
    UniProtKB/Swiss-Prot
    Q16186
    Conserved Domains (2) summary
    cd13314
    Location:24128
    PH_Rpn13; Pleckstrin homology-like domain of Regulatory Particle Non-ATPase 13
    pfam16550
    Location:274381
    RPN13_C; UCH-binding domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p12 Primary Assembly

    Range
    62302061..62308862
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027602.1XP_016883091.1  proteasomal ubiquitin receptor ADRM1 isoform X3

  2. XM_017027605.1XP_016883094.1  proteasomal ubiquitin receptor ADRM1 isoform X5

  3. XM_024451814.1XP_024307582.1  proteasomal ubiquitin receptor ADRM1 isoform X1

    Conserved Domains (2) summary
    cd13314
    Location:24128
    PH_Rpn13; Pleckstrin homology-like domain of Regulatory Particle Non-ATPase 13
    pfam16550
    Location:274444
    RPN13_C; UCH-binding domain
  4. XM_011528503.1XP_011526805.1  proteasomal ubiquitin receptor ADRM1 isoform X6

    Conserved Domains (2) summary
    cd13314
    Location:24128
    PH_Rpn13; Pleckstrin homology-like domain of Regulatory Particle Non-ATPase 13
    pfam16550
    Location:274338
    RPN13_C; UCH-binding domain
  5. XM_024451816.1XP_024307584.1  proteasomal ubiquitin receptor ADRM1 isoform X2

    Conserved Domains (2) summary
    pfam16550
    Location:235405
    RPN13_C; UCH-binding domain
    cl17171
    Location:2489
    PH-like; Pleckstrin homology-like domain
  6. XM_024451819.1XP_024307587.1  proteasomal ubiquitin receptor ADRM1 isoform X7

    Conserved Domains (1) summary
    pfam16550
    Location:142312
    RPN13_C; UCH-binding domain
  7. XM_017027610.1XP_016883099.1  proteasomal ubiquitin receptor ADRM1 isoform X8

  8. XM_024451815.1XP_024307583.1  proteasomal ubiquitin receptor ADRM1 isoform X1

    Conserved Domains (2) summary
    cd13314
    Location:24128
    PH_Rpn13; Pleckstrin homology-like domain of Regulatory Particle Non-ATPase 13
    pfam16550
    Location:274444
    RPN13_C; UCH-binding domain
  9. XM_024451817.1XP_024307585.1  proteasomal ubiquitin receptor ADRM1 isoform X2

    Conserved Domains (2) summary
    pfam16550
    Location:235405
    RPN13_C; UCH-binding domain
    cl17171
    Location:2489
    PH-like; Pleckstrin homology-like domain
  10. XM_024451818.1XP_024307586.1  proteasomal ubiquitin receptor ADRM1 isoform X4

    Related
    ENSP00000478877.1, ENST00000491935.5
    Conserved Domains (2) summary
    cd13314
    Location:24128
    PH_Rpn13; Pleckstrin homology-like domain of Regulatory Particle Non-ATPase 13
    pfam16550
    Location:274381
    RPN13_C; UCH-binding domain
Support Center