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ADRM1 ADRM1 26S proteasome ubiquitin receptor [ Homo sapiens (human) ]

Gene ID: 11047, updated on 8-Apr-2026
Official Symbol
ADRM1provided by HGNC
Official Full Name
ADRM1 26S proteasome ubiquitin receptorprovided by HGNC
Primary source
HGNC:HGNC:15759
See related
Ensembl:ENSG00000130706 MIM:610650; AllianceGenome:HGNC:15759
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARM1; ARM-1; GP110; PSMD16
Summary
This gene encodes a member of the adhesion regulating molecule 1 protein family. The encoded protein is a component of the proteasome where it acts as a ubiquitin receptor and recruits the deubiquitinating enzyme, ubiquitin carboxyl-terminal hydrolase L5. Increased levels of the encoded protein are associated with increased cell adhesion, which is likely an indirect effect of this intracellular protein. Dysregulation of this gene has been implicated in carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Expression
Ubiquitous expression in testis (RPKM 31.4), fat (RPKM 17.5) and 25 other tissues See more
Orthologs
all
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Try the new Transcripts and proteins table
See ADRM1 in Genome Data Viewer
Location:
20q13.33
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (62302896..62308862)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (64093845..64099811)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (60877952..60883918)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369209 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:60803162-60804062 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13105 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:60814402-60815326 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60818849-60819457 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60819458-60820065 Neighboring gene oxysterol binding protein like 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60831784-60832284 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60853989-60854489 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13106 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13107 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60880842-60881345 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13108 Neighboring gene Sharpr-MPRA regulatory region 11098 Neighboring gene laminin subunit alpha 5 Neighboring gene uncharacterized LOC124904946 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18197 Neighboring gene microRNA 4758

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Early and consistent overexpression of ADRM1 in ovarian high-grade serous carcinoma. Jiang RT, et al. J Ovarian Res, 2017 Aug 7. PMID 28784174, Free PMC Article
  2. Molecular cloning and characterization of the complementary DNA of an M(r) 110,000 antigen expressed by human gastric carcinoma cells and upregulated by gamma-interferon. Shimada S, et al. Cancer Res, 1994 Jul 15. PMID 8033103
  3. Comprehensive analysis of 20q13 genes in ovarian cancer identifies ADRM1 as amplification target. Fejzo MS, et al. Genes Chromosomes Cancer, 2008 Oct. PMID 18615678
  4. Knockdown of the novel proteasome subunit Adrm1 located on the 20q13 amplicon inhibits colorectal cancer cell migration, survival and tumorigenicity. Chen W, et al. Oncol Rep, 2009 Feb. PMID 19148532
  5. [Silencing of Adrm1 by RNA interference suppresses proliferation of colorectal cancer cells]. Chen W, et al. Zhonghua Zhong Liu Za Zhi, 2009 Nov. PMID 20137344

See all (193) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The high expression of ADRM1 in hepatocellular carcinoma is closely related to tumor immune infiltration and is regulated by miR-891a-5p.
    Title: The high expression of ADRM1 in hepatocellular carcinoma is closely related to tumor immune infiltration and is regulated by miR-891a-5p.
  2. hRpn13 shapes the proteome and transcriptome through epigenetic factors HDAC8, PADI4, and transcription factor NF-kappaB p50.
    Title: hRpn13 shapes the proteome and transcriptome through epigenetic factors HDAC8, PADI4, and transcription factor NF-κB p50.
  3. Potential of adhesion-regulating molecule 1 (ADRM1) as a biomarker for patients with renal clear-cell carcinoma or papillary-cell carcinoma.
    Title: Potential of adhesion-regulating molecule 1 (ADRM1) as a biomarker for patients with renal clear-cell carcinoma or papillary-cell carcinoma.
  4. LIM Homeobox 2 Increases Adhesion-Regulating Molecule 1 Transcription to Facilitate the Pathological Progression of Oxidized Low-Density Lipoprotein-Stimulated Atherosclerotic Cell Models.
    Title: LIM Homeobox 2 Increases Adhesion-Regulating Molecule 1 Transcription to Facilitate the Pathological Progression of Oxidized Low-Density Lipoprotein-Stimulated Atherosclerotic Cell Models.
  5. Structure-guided bifunctional molecules hit a DEUBAD-lacking hRpn13 species upregulated in multiple myeloma.
    Title: Structure-guided bifunctional molecules hit a DEUBAD-lacking hRpn13 species upregulated in multiple myeloma.
  6. ADRM1 as a therapeutic target in hepatocellular carcinoma.
    Title: ADRM1 as a therapeutic target in hepatocellular carcinoma.
  7. Identification of novel anti-tumor therapeutic target via proteomic characterization of ubiquitin receptor ADRM1/Rpn13.
    Title: Identification of novel anti-tumor therapeutic target via proteomic characterization of ubiquitin receptor ADRM1/Rpn13.
  8. An Extended Conformation for K48 Ubiquitin Chains Revealed by the hRpn2:Rpn13:K48-Diubiquitin Structure.
    Title: An Extended Conformation for K48 Ubiquitin Chains Revealed by the hRpn2:Rpn13:K48-Diubiquitin Structure.
  9. Prognostic and Therapeutic Significance of Adhesion-regulating Molecule 1 in Estrogen Receptor-positive Breast Cancer.
    Title: Prognostic and Therapeutic Significance of Adhesion-regulating Molecule 1 in Estrogen Receptor-positive Breast Cancer.
  10. Proteomic analysis identifies mechanism(s) of overcoming bortezomib resistance via targeting ubiquitin receptor Rpn13.
    Title: Proteomic analysis identifies mechanism(s) of overcoming bortezomib resistance via targeting ubiquitin receptor Rpn13.
Submit: New GeneRIF Correction See all GeneRIFs (45)

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
EBI GWAS Catalog

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC29536

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables endopeptidase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables endopeptidase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables molecular function inhibitor activity EXP
Inferred from Experiment
more info
 PubMed 
enables protease binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables proteasome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables proteasome binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to type I interferon NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in proteasomal protein catabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in proteasome assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of proteasomal protein catabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in response to oxidative stress NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in transcription elongation by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome regulatory particle, lid subcomplex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synaptic vesicle NAS
Non-traceable Author Statement
more info
 PubMed 
Preferred Names
proteasomal ubiquitin receptor ADRM1
Names
110 kDa cell membrane glycoprotein
M(r) 110,000 surface antigen
adhesion regulating molecule 1
proteasome regulatory particle non-ATPase 13
proteasome ubiquitin receptor
rpn13 homolog

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050661.2 RefSeqGene

    Range
    5103..10968
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001281437.1 → NP_001268366.1  proteasomal ubiquitin receptor ADRM1 isoform 2

    See identical proteins and their annotated locations for NP_001268366.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1. Variants 3 and 4 encode the same isoform.
    Source sequence(s)
    BC017245, BR000321, HY029018, HY178253
    Consensus CDS
    CCDS74747.1
    UniProtKB/TrEMBL
    A0A087WX59
    Related
    ENSP00000576376.1, ENST00000906317.1
    Conserved Domains (2) summary
    pfam16550
    Location:235 → 342
    RPN13_C; UCH-binding domain
    cl17171
    Location:24 → 89
    PH-like; Pleckstrin homology-like domain

  2. NM_001281438.1 → NP_001268367.1  proteasomal ubiquitin receptor ADRM1 isoform 2

    See identical proteins and their annotated locations for NP_001268367.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1. Variants 3 and 4 encode the same isoform.
    Source sequence(s)
    BC017245, BG337785, BR000321, HY029018
    Consensus CDS
    CCDS74747.1
    UniProtKB/TrEMBL
    A0A087WX59
    Related
    ENSP00000480756.1, ENST00000620230.4
    Conserved Domains (2) summary
    pfam16550
    Location:235 → 342
    RPN13_C; UCH-binding domain
    cl17171
    Location:24 → 89
    PH-like; Pleckstrin homology-like domain

  3. NM_007002.4 → NP_008933.2  proteasomal ubiquitin receptor ADRM1 isoform 1

    See identical proteins and their annotated locations for NP_008933.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AL354836
    Consensus CDS
    CCDS13496.1
    UniProtKB/Swiss-Prot
    A0PKB1, Q16186, Q96FJ7, Q9H1P2
    Related
    ENSP00000253003.2, ENST00000253003.7
    Conserved Domains (2) summary
    cd13314
    Location:24 → 128
    PH_Rpn13; Pleckstrin homology-like domain of Regulatory Particle Non-ATPase 13
    pfam16550
    Location:274 → 381
    RPN13_C; UCH-binding domain

  4. NM_175573.2 → NP_783163.1  proteasomal ubiquitin receptor ADRM1 isoform 1

    See identical proteins and their annotated locations for NP_783163.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    BC017245, BR000321, HY029018
    Consensus CDS
    CCDS13496.1
    UniProtKB/Swiss-Prot
    A0PKB1, Q16186, Q96FJ7, Q9H1P2
    Related
    ENSP00000576372.1, ENST00000906313.1
    Conserved Domains (2) summary
    cd13314
    Location:24 → 128
    PH_Rpn13; Pleckstrin homology-like domain of Regulatory Particle Non-ATPase 13
    pfam16550
    Location:274 → 381
    RPN13_C; UCH-binding domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    62302896..62308862
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528503.2 → XP_011526805.1  proteasomal ubiquitin receptor ADRM1 isoform X1

    UniProtKB/TrEMBL
    Q68E00
    Conserved Domains (2) summary
    cd13314
    Location:24 → 128
    PH_Rpn13; Pleckstrin homology-like domain of Regulatory Particle Non-ATPase 13
    pfam16550
    Location:274 → 338
    RPN13_C; UCH-binding domain

  2. XM_047439841.1 → XP_047295797.1  proteasomal ubiquitin receptor ADRM1 isoform X2

    UniProtKB/TrEMBL
    Q68E00

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    64093845..64099811
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322873.1 → XP_054178848.1  proteasomal ubiquitin receptor ADRM1 isoform X1

    UniProtKB/TrEMBL
    Q68E00

  2. XM_054322874.1 → XP_054178849.1  proteasomal ubiquitin receptor ADRM1 isoform X2

    UniProtKB/TrEMBL
    Q68E00
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q16186.2 GenPept UniProtKB/Swiss-Prot:Q16186

Gene LinkOut

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