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Rap1gap Rap1 GTPase-activating protein [ Mus musculus (house mouse) ]

Gene ID: 110351, updated on 12-May-2024

Summary

Official Symbol
Rap1gapprovided by MGI
Official Full Name
Rap1 GTPase-activating proteinprovided by MGI
Primary source
MGI:MGI:109338
See related
Ensembl:ENSMUSG00000041351 AllianceGenome:MGI:109338
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gap; ARPP-90; Rap1ga1; Rap1GAP1; 1300019I11Rik; 2310004O14Rik
Summary
Predicted to enable GTPase activator activity; protein homodimerization activity; and small GTPase binding activity. Acts upstream of or within positive regulation of cell-cell adhesion and positive regulation of phagocytosis. Predicted to be located in several cellular components, including dendrite; early endosome; and neuronal cell body. Predicted to be active in cytoplasm and membrane. Is expressed in several structures, including metanephros; nervous system; olfactory epithelium; pancreas; and skeleton. Orthologous to human RAP1GAP (RAP1 GTPase activating protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in adrenal adult (RPKM 86.3), colon adult (RPKM 64.5) and 19 other tissues See more
Orthologs
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Genomic context

See Rap1gap in Genome Data Viewer
Location:
4 D3; 4 70.02 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (137391549..137457172)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (137664711..137729861)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene low density lipoprotein receptor class A domain containing 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:137149587-137149696 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:137150478-137150661 Neighboring gene STARR-seq mESC enhancer starr_11788 Neighboring gene ubiquitin specific peptidase 48 Neighboring gene predicted gene, 54263 Neighboring gene RAP1 GTPase activating protein, opposite strand Neighboring gene predicted gene, 52682 Neighboring gene alkaline phosphatase, liver/bone/kidney Neighboring gene STARR-seq mESC enhancer starr_11793 Neighboring gene STARR-positive B cell enhancer ABC_E4691 Neighboring gene STARR-seq mESC enhancer starr_11795 Neighboring gene predicted gene, 32079

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables GTPase regulator activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
rap1 GTPase-activating protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081155.4NP_001074624.1  rap1 GTPase-activating protein 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    AL805954
    Consensus CDS
    CCDS38925.1
    UniProtKB/Swiss-Prot
    A2ALS5
    Related
    ENSMUSP00000042473.6, ENSMUST00000047243.12
    Conserved Domains (2) summary
    smart00390
    Location:6181
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:275454
    Rap_GAP; Rap/ran-GAP
  2. NM_001256218.2NP_001243147.1  rap1 GTPase-activating protein 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses two different splice sites in the 3' coding region which shifts the reading frame, compared to variant 1. The resulting protein (isoform 2) has a longer and distinct C-terminus when it is compared to isoform 1.
    Source sequence(s)
    AL805954
    Consensus CDS
    CCDS57306.1
    UniProtKB/TrEMBL
    A2ALS4
    Related
    ENSMUSP00000101461.2, ENSMUST00000105835.8
    Conserved Domains (2) summary
    smart00390
    Location:6181
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:275454
    Rap_GAP; Rap/ran-GAP
  3. NM_001331215.2NP_001318144.1  rap1 GTPase-activating protein 1 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) represents use of an alternate promoter and differs in the 5' UTR and 5' coding region compared to variant 1. The encoded isoform (4) has a shorter, distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AL805954
    Consensus CDS
    CCDS84809.1
    UniProtKB/Swiss-Prot
    A2ALS5
    Related
    ENSMUSP00000095448.5, ENSMUST00000097837.11
  4. NM_001379233.1NP_001366162.1  rap1 GTPase-activating protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL805954
    Conserved Domains (2) summary
    smart00390
    Location:6181
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:275454
    Rap_GAP; Rap/ran-GAP
  5. NM_001379234.1NP_001366163.1  rap1 GTPase-activating protein 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL805954
    Conserved Domains (2) summary
    smart00390
    Location:2848
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:242421
    Rap_GAP; Rap/ran-GAP
  6. NM_001379235.1NP_001366164.1  rap1 GTPase-activating protein 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL805954
    Conserved Domains (2) summary
    smart00390
    Location:4969
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:263442
    Rap_GAP; Rap/ran-GAP
  7. NM_001379236.1NP_001366165.1  rap1 GTPase-activating protein 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL805954
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  8. NM_029563.3NP_083839.1  rap1 GTPase-activating protein 1 isoform 3

    See identical proteins and their annotated locations for NP_083839.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents use of an alternate promoter and initiates translation at a downstream start codon, compared to variant 1. The encoded protein (isoform 3) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AL805954
    UniProtKB/Swiss-Prot
    A2ALS5, E9PZZ8, Q6A063, Q80VZ8, Q8K2L6
    Conserved Domains (2) summary
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
    pfam02188
    Location:117
    GoLoco; GoLoco motif

RNA

  1. NR_138591.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents use of an alternate promoter and uses an alternate splice site compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL805954
  2. NR_138592.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) represents use of an alternate promoter, differs in the 5' region, and uses an alternate splice site in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK005063, AK019076

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    137391549..137457172
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538482.5XP_006538545.1  rap1 GTPase-activating protein 1 isoform X8

    See identical proteins and their annotated locations for XP_006538545.1

    Conserved Domains (2) summary
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
    pfam02188
    Location:117
    GoLoco; GoLoco motif
  2. XM_006538483.5XP_006538546.1  rap1 GTPase-activating protein 1 isoform X8

    See identical proteins and their annotated locations for XP_006538546.1

    Conserved Domains (2) summary
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
    pfam02188
    Location:117
    GoLoco; GoLoco motif
  3. XM_030253087.2XP_030108947.1  rap1 GTPase-activating protein 1 isoform X9

    Conserved Domains (2) summary
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
    pfam02188
    Location:117
    GoLoco; GoLoco motif
  4. XM_030253084.1XP_030108944.1  rap1 GTPase-activating protein 1 isoform X6

    Conserved Domains (2) summary
    pfam02145
    Location:263442
    Rap_GAP; Rap/ran-GAP
    pfam02188
    Location:4969
    GoLoco; GoLoco motif
  5. XM_006538475.5XP_006538538.1  rap1 GTPase-activating protein 1 isoform X1

    Conserved Domains (2) summary
    pfam02145
    Location:275454
    Rap_GAP; Rap/ran-GAP
    pfam02188
    Location:6181
    GoLoco; GoLoco motif
  6. XM_006538478.4XP_006538541.1  rap1 GTPase-activating protein 1 isoform X3

    Conserved Domains (2) summary
    pfam02145
    Location:263442
    Rap_GAP; Rap/ran-GAP
    pfam02188
    Location:4969
    GoLoco; GoLoco motif
  7. XM_036163582.1XP_036019475.1  rap1 GTPase-activating protein 1 isoform X2

    Conserved Domains (2) summary
    smart00390
    Location:5070
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:264443
    Rap_GAP; Rap/ran-GAP
  8. XM_036163583.1XP_036019476.1  rap1 GTPase-activating protein 1 isoform X4

    Conserved Domains (2) summary
    smart00390
    Location:3858
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:252431
    Rap_GAP; Rap/ran-GAP
  9. XM_036163584.1XP_036019477.1  rap1 GTPase-activating protein 1 isoform X7

    Conserved Domains (2) summary
    smart00390
    Location:3858
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:252431
    Rap_GAP; Rap/ran-GAP
  10. XM_006538480.2XP_006538543.1  rap1 GTPase-activating protein 1 isoform X5

    Conserved Domains (2) summary
    pfam02145
    Location:242421
    Rap_GAP; Rap/ran-GAP
    pfam02188
    Location:2848
    GoLoco; GoLoco motif

RNA

  1. XR_003954867.2 RNA Sequence

  2. XR_003954870.2 RNA Sequence

  3. XR_003954866.2 RNA Sequence

  4. XR_003954868.2 RNA Sequence

  5. XR_004941798.1 RNA Sequence

  6. XR_004941796.1 RNA Sequence

  7. XR_004941797.1 RNA Sequence

  8. XR_390722.2 RNA Sequence

  9. XR_390723.4 RNA Sequence

  10. XR_001784080.2 RNA Sequence

  11. XR_001784081.3 RNA Sequence

  12. XR_004941795.1 RNA Sequence

  13. XR_003954869.2 RNA Sequence