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RAP1GAP RAP1 GTPase activating protein [ Homo sapiens (human) ]

Gene ID: 5909, updated on 23-Oct-2021

Summary

Official Symbol
RAP1GAPprovided by HGNC
Official Full Name
RAP1 GTPase activating proteinprovided by HGNC
Primary source
HGNC:HGNC:9858
See related
Ensembl:ENSG00000076864 MIM:600278
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAPGAP; RAP1GA1; RAP1GAP1; RAP1GAPII
Summary
This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active GTP-bound form. The product of this gene, RAP1GAP, promotes the hydrolysis of bound GTP and hence returns RAP1 to the inactive state whereas other proteins, guanine nucleotide exchange factors (GEFs), act as RAP1 activators by facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, ras subfamily proteins, such as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1 plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Aug 2011]
Expression
Biased expression in thyroid (RPKM 75.3), brain (RPKM 38.1) and 11 other tissues See more
Orthologs
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Genomic context

See RAP1GAP in Genome Data Viewer
Location:
1p36.12
Exon count:
32
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (21596221..21669413, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (21922714..21995850, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene alkaline phosphatase, biomineralization associated Neighboring gene long intergenic non-protein coding RNA 2596 Neighboring gene ubiquitin specific peptidase 48 Neighboring gene Sharpr-MPRA regulatory region 6146 Neighboring gene low density lipoprotein receptor class A domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0474

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase activator activity EXP
Inferred from Experiment
more info
PubMed 
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables GTPase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
located_in axon IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 
located_in early endosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
rap1 GTPase-activating protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029807.1 RefSeqGene

    Range
    5007..78143
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001145657.3NP_001139129.1  rap1 GTPase-activating protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001139129.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses two alternate in-frame splice junctions compared to variant 4. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform 4. Isoform 2 is also known as isoform b.
    Source sequence(s)
    AB007943, BC035030, HY115754
    Consensus CDS
    CCDS53276.1
    UniProtKB/Swiss-Prot
    P47736
    Related
    ENSP00000441661.1, ENST00000542643.6
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  2. NM_001145658.3NP_001139130.1  rap1 GTPase-activating protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001139130.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 4. The resulting isoform (1) is longer at the N-terminus and lacks an alternate internal segment compared to isoform 4. Isoform 1 is also known as isoform a.
    Source sequence(s)
    AL359815, BC035030, BC054490, BM739021, BP200029, CV574545
    Consensus CDS
    CCDS53277.1
    UniProtKB/Swiss-Prot
    P47736
    Related
    ENSP00000434033.2, ENST00000495204.5
    Conserved Domains (2) summary
    smart00390
    Location:6181
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:275454
    Rap_GAP; Rap/ran-GAP
  3. NM_001330383.3NP_001317312.1  rap1 GTPase-activating protein 1 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) encodes the longest isoform (4). Isoform 4 is also known as isoform d.
    Source sequence(s)
    AB007943, BC035030, BI546732, BM742308, HY115754
    Consensus CDS
    CCDS81276.1
    UniProtKB/TrEMBL
    X6R8W7
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  4. NM_001350524.2NP_001337453.1  rap1 GTPase-activating protein 1 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: Isoform 5 is also known as isoform e.
    Source sequence(s)
    AB007943, AI301600, BC035030, BI546732, HY115754
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  5. NM_001350525.2NP_001337454.1  rap1 GTPase-activating protein 1 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: Isoform 6 is also known as isoform f.
    Source sequence(s)
    AB007943, AI301600, BC035030, BX094488, HY115754
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  6. NM_001350526.2NP_001337455.1  rap1 GTPase-activating protein 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AB007943, AF114047, AI301600, AL359815, BC035030, BX094488, HY115754
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  7. NM_001350527.2NP_001337456.1  rap1 GTPase-activating protein 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AB007943, AI301600, BC035030, BM821324, BX094488, HY115754, HY136222
    Consensus CDS
    CCDS218.1
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  8. NM_001350528.2NP_001337457.1  rap1 GTPase-activating protein 1 isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: Isoform 7 is also known as isoform g.
    Source sequence(s)
    AB007943, AI301600, BC035030, BM821324, BX094488, CF139631, HY115754, HY136222
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  9. NM_001388200.1NP_001375129.1  rap1 GTPase-activating protein 1 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  10. NM_001388201.1NP_001375130.1  rap1 GTPase-activating protein 1 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  11. NM_001388202.1NP_001375131.1  rap1 GTPase-activating protein 1 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  12. NM_001388203.1NP_001375132.1  rap1 GTPase-activating protein 1 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  13. NM_001388204.1NP_001375133.1  rap1 GTPase-activating protein 1 isoform 17

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  14. NM_001388205.1NP_001375134.1  rap1 GTPase-activating protein 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Related
    ENSP00000363895.2, ENST00000374763.6
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  15. NM_001388206.1NP_001375135.1  rap1 GTPase-activating protein 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  16. NM_001388207.1NP_001375136.1  rap1 GTPase-activating protein 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Related
    ENSP00000290101.5, ENST00000290101.8
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  17. NM_001388208.1NP_001375137.1  rap1 GTPase-activating protein 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  18. NM_001388209.1NP_001375138.1  rap1 GTPase-activating protein 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  19. NM_001388210.1NP_001375139.1  rap1 GTPase-activating protein 1 isoform 18

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  20. NM_001388211.1NP_001375140.1  rap1 GTPase-activating protein 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  21. NM_001388212.1NP_001375141.1  rap1 GTPase-activating protein 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  22. NM_001388213.1NP_001375142.1  rap1 GTPase-activating protein 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  23. NM_001388214.1NP_001375143.1  rap1 GTPase-activating protein 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  24. NM_001388215.1NP_001375144.1  rap1 GTPase-activating protein 1 isoform 19

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211366
    Rap_GAP; Rap/ran-GAP
  25. NM_001388216.1NP_001375145.1  rap1 GTPase-activating protein 1 isoform 20

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  26. NM_001388217.1NP_001375146.1  rap1 GTPase-activating protein 1 isoform 21

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  27. NM_001388218.1NP_001375147.1  rap1 GTPase-activating protein 1 isoform 22

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (3) summary
    PTZ00449
    Location:456603
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  28. NM_001388219.1NP_001375148.1  rap1 GTPase-activating protein 1 isoform 23

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:183362
    Rap_GAP; Rap/ran-GAP
  29. NM_001388220.1NP_001375149.1  rap1 GTPase-activating protein 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  30. NM_001388221.1NP_001375150.1  rap1 GTPase-activating protein 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  31. NM_001388222.1NP_001375151.1  rap1 GTPase-activating protein 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  32. NM_001388223.1NP_001375152.1  rap1 GTPase-activating protein 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  33. NM_001388224.1NP_001375153.1  rap1 GTPase-activating protein 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  34. NM_001388225.1NP_001375154.1  rap1 GTPase-activating protein 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  35. NM_001388226.1NP_001375155.1  rap1 GTPase-activating protein 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  36. NM_001388227.1NP_001375156.1  rap1 GTPase-activating protein 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  37. NM_001388228.1NP_001375157.1  rap1 GTPase-activating protein 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  38. NM_001388229.1NP_001375158.1  rap1 GTPase-activating protein 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  39. NM_001388230.1NP_001375159.1  rap1 GTPase-activating protein 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  40. NM_001388231.1NP_001375160.1  rap1 GTPase-activating protein 1 isoform 24

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (1) summary
    pfam02145
    Location:202381
    Rap_GAP; Rap/ran-GAP
  41. NM_001388233.1NP_001375162.1  rap1 GTPase-activating protein 1 isoform 25

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:198377
    Rap_GAP; Rap/ran-GAP
  42. NM_001388234.1NP_001375163.1  rap1 GTPase-activating protein 1 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211373
    Rap_GAP; Rap/ran-GAP
  43. NM_001388235.1NP_001375164.1  rap1 GTPase-activating protein 1 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211373
    Rap_GAP; Rap/ran-GAP
  44. NM_001388236.1NP_001375165.1  rap1 GTPase-activating protein 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  45. NM_001388237.1NP_001375166.1  rap1 GTPase-activating protein 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  46. NM_001388238.1NP_001375167.1  rap1 GTPase-activating protein 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  47. NM_001388239.1NP_001375168.1  rap1 GTPase-activating protein 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  48. NM_001388240.1NP_001375169.1  rap1 GTPase-activating protein 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  49. NM_001388241.1NP_001375170.1  rap1 GTPase-activating protein 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Related
    ENSP00000363893.2, ENST00000374761.6
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  50. NM_001388242.1NP_001375171.1  rap1 GTPase-activating protein 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  51. NM_001388243.1NP_001375172.1  rap1 GTPase-activating protein 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  52. NM_001388244.1NP_001375173.1  rap1 GTPase-activating protein 1 isoform 26

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:183362
    Rap_GAP; Rap/ran-GAP
  53. NM_001388245.1NP_001375174.1  rap1 GTPase-activating protein 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  54. NM_001388246.1NP_001375175.1  rap1 GTPase-activating protein 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  55. NM_001388247.1NP_001375176.1  rap1 GTPase-activating protein 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  56. NM_001388248.1NP_001375177.1  rap1 GTPase-activating protein 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  57. NM_001388249.1NP_001375178.1  rap1 GTPase-activating protein 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  58. NM_001388250.1NP_001375179.1  rap1 GTPase-activating protein 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  59. NM_001388251.1NP_001375180.1  rap1 GTPase-activating protein 1 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  60. NM_001388252.1NP_001375181.1  rap1 GTPase-activating protein 1 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  61. NM_001388253.1NP_001375182.1  rap1 GTPase-activating protein 1 isoform 27

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211373
    Rap_GAP; Rap/ran-GAP
  62. NM_001388254.1NP_001375183.1  rap1 GTPase-activating protein 1 isoform 28

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  63. NM_001388255.1NP_001375184.1  rap1 GTPase-activating protein 1 isoform 29

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  64. NM_001388256.1NP_001375185.1  rap1 GTPase-activating protein 1 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211366
    Rap_GAP; Rap/ran-GAP
  65. NM_001388258.1NP_001375187.1  rap1 GTPase-activating protein 1 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211366
    Rap_GAP; Rap/ran-GAP
  66. NM_001388259.1NP_001375188.1  rap1 GTPase-activating protein 1 isoform 30

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211373
    Rap_GAP; Rap/ran-GAP
  67. NM_001388261.1NP_001375190.1  rap1 GTPase-activating protein 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  68. NM_001388263.1NP_001375192.1  rap1 GTPase-activating protein 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  69. NM_001388264.1NP_001375193.1  rap1 GTPase-activating protein 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  70. NM_001388266.1NP_001375195.1  rap1 GTPase-activating protein 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  71. NM_001388267.1NP_001375196.1  rap1 GTPase-activating protein 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  72. NM_001388269.1NP_001375198.1  rap1 GTPase-activating protein 1 isoform 31

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (1) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
  73. NM_001388270.1NP_001375199.1  rap1 GTPase-activating protein 1 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  74. NM_001388273.1NP_001375202.1  rap1 GTPase-activating protein 1 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  75. NM_001388276.1NP_001375205.1  rap1 GTPase-activating protein 1 isoform 32

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (1) summary
    pfam02145
    Location:56235
    Rap_GAP; Rap/ran-GAP
  76. NM_001388279.1NP_001375208.1  rap1 GTPase-activating protein 1 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (1) summary
    pfam02145
    Location:56235
    Rap_GAP; Rap/ran-GAP
  77. NM_001388280.1NP_001375209.1  rap1 GTPase-activating protein 1 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (1) summary
    pfam02145
    Location:56235
    Rap_GAP; Rap/ran-GAP
  78. NM_001388281.1NP_001375210.1  rap1 GTPase-activating protein 1 isoform 33

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (1) summary
    pfam02145
    Location:56235
    Rap_GAP; Rap/ran-GAP
  79. NM_001388282.1NP_001375211.1  rap1 GTPase-activating protein 1 isoform 34

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (1) summary
    pfam02145
    Location:172351
    Rap_GAP; Rap/ran-GAP
  80. NM_001388283.1NP_001375212.1  rap1 GTPase-activating protein 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Related
    ENSP00000431364.1, ENST00000471600.6
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  81. NM_001388284.1NP_001375213.1  rap1 GTPase-activating protein 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  82. NM_001388285.1NP_001375214.1  rap1 GTPase-activating protein 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP
  83. NM_001388286.1NP_001375215.1  rap1 GTPase-activating protein 1 isoform 35

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:6181
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:275437
    Rap_GAP; Rap/ran-GAP
  84. NM_001388287.1NP_001375216.1  rap1 GTPase-activating protein 1 isoform 36

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:6181
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:275454
    Rap_GAP; Rap/ran-GAP
  85. NM_001388288.1NP_001375217.1  rap1 GTPase-activating protein 1 isoform 37

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:6181
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:275454
    Rap_GAP; Rap/ran-GAP
  86. NM_001388289.1NP_001375218.1  rap1 GTPase-activating protein 1 isoform 38

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:6181
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:275454
    Rap_GAP; Rap/ran-GAP
  87. NM_001388290.1NP_001375219.1  rap1 GTPase-activating protein 1 isoform 39

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:6181
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:275452
    Rap_GAP; Rap/ran-GAP
  88. NM_001388291.1NP_001375220.1  rap1 GTPase-activating protein 1 isoform 40

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:6181
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:275430
    Rap_GAP; Rap/ran-GAP
  89. NM_001388292.1NP_001375221.1  rap1 GTPase-activating protein 1 isoform 41

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:6181
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:275454
    Rap_GAP; Rap/ran-GAP
  90. NM_001388293.1NP_001375222.1  rap1 GTPase-activating protein 1 isoform 42

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:6181
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:275454
    Rap_GAP; Rap/ran-GAP
  91. NM_001388294.1NP_001375223.1  rap1 GTPase-activating protein 1 isoform 43

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:6181
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:275454
    Rap_GAP; Rap/ran-GAP
  92. NM_001388295.1NP_001375224.1  rap1 GTPase-activating protein 1 isoform 44

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:6181
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:275454
    Rap_GAP; Rap/ran-GAP
  93. NM_001388296.1NP_001375225.1  rap1 GTPase-activating protein 1 isoform 45

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:6181
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:275454
    Rap_GAP; Rap/ran-GAP
  94. NM_002885.4NP_002876.2  rap1 GTPase-activating protein 1 isoform 3

    See identical proteins and their annotated locations for NP_002876.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 4. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 4. Variants 3 and 8 encode the same protein (isoform 3). Isoform 3 is also known as isoform c.
    Source sequence(s)
    AB007943, AL359815, BC035030, HY115754, M64788
    Consensus CDS
    CCDS218.1
    UniProtKB/Swiss-Prot
    P47736
    UniProtKB/TrEMBL
    A0A024RAB5
    Related
    ENSP00000363897.4, ENST00000374765.9
    Conserved Domains (2) summary
    smart00390
    Location:117
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211390
    Rap_GAP; Rap/ran-GAP

RNA

  1. NR_170899.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL359815
  2. NR_170900.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL359815
  3. NR_170901.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL359815
  4. NR_170902.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Related
    ENST00000611549.4
  5. NR_170903.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL359815
  6. NR_170904.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL359815
  7. NR_170905.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL359815
  8. NR_170906.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL359815
  9. NR_170907.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL359815
  10. NR_170908.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL359815
  11. NR_170909.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL359815
  12. NR_170910.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL359815
  13. NR_170911.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL359815
  14. NR_170912.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL359815
  15. NR_170913.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL359815
  16. NR_170914.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL359815
  17. NR_170915.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL359815
  18. NR_170916.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL359815
  19. NR_170920.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL359815
  20. NR_170921.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL359815
  21. NR_170923.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL359815
  22. NR_170924.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL359815
  23. NR_170925.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL359815
  24. NR_170926.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL359815
  25. NR_170927.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL359815
  26. NR_170928.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL359815
  27. NR_170929.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL359815

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    21596221..21669413 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_946726.1 RNA Sequence

  2. XR_001737352.1 RNA Sequence

  3. XR_001737354.1 RNA Sequence

  4. XR_946728.2 RNA Sequence

  5. XR_001737351.1 RNA Sequence

  6. XR_946730.2 RNA Sequence

  7. XR_001737349.2 RNA Sequence

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