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Hba-a2 hemoglobin alpha, adult chain 2 [ Mus musculus (house mouse) ]

Gene ID: 110257, updated on 8-Feb-2024

Summary

Official Symbol
Hba-a2provided by MGI
Official Full Name
hemoglobin alpha, adult chain 2provided by MGI
Primary source
MGI:MGI:96016
See related
Ensembl:ENSMUSG00000069917 AllianceGenome:MGI:96016
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Acts upstream of or within erythrocyte development; in utero embryonic development; and response to bacterium. Is expressed in visceral pericardium and yolk sac. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 52386.2), heart adult (RPKM 17186.2) and 4 other tissues See more
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Genomic context

Location:
11 A4; 11 18.87 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (32246492..32247310)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (32296492..32297310)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene hemoglobin alpha, adult chain 1 Neighboring gene hemoglobin, theta 1B Neighboring gene hemoglobin, theta 1A Neighboring gene predicted gene, 46275

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Radiation induced (1)  1 citation
  • Endonuclease-mediated (2) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to haptoglobin binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to peroxidase activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
part_of haptoglobin-hemoglobin complex ISO
Inferred from Sequence Orthology
more info
 
part_of hemoglobin complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
hemoglobin alpha, adult chain 2
Names
alpha 2 globin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083955.1NP_001077424.1  hemoglobin alpha, adult chain 2

    See identical proteins and their annotated locations for NP_001077424.1

    Status: VALIDATED

    Source sequence(s)
    AK005434, CF740193
    Consensus CDS
    CCDS48766.1
    UniProtKB/Swiss-Prot
    P01942
    UniProtKB/TrEMBL
    A8DUV3, Q8BPF4, Q91VB8, Q9CWS5, Q9CY06
    Related
    ENSMUSP00000090895.4, ENSMUST00000093207.4
    Conserved Domains (1) summary
    cd08927
    Location:3142
    Hb-alpha_like; Hemoglobin alpha, zeta, mu, theta, and related Hb subunits

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    32246492..32247310
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)