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Cbr3 carbonyl reductase 3 [ Mus musculus (house mouse) ]

Gene ID: 109857, updated on 8-Feb-2024

Summary

Official Symbol
Cbr3provided by MGI
Official Full Name
carbonyl reductase 3provided by MGI
Primary source
MGI:MGI:1309992
See related
Ensembl:ENSMUSG00000022947 AllianceGenome:MGI:1309992
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110001J05Rik
Summary
Predicted to enable 3-keto sterol reductase activity; NADPH binding activity; and carbonyl reductase (NADPH) activity. Predicted to be involved in cognition and phylloquinone catabolic process. Predicted to be located in cytosol and nucleoplasm. Is expressed in several structures, including alimentary system; genitourinary system; musculoskeletal system; nervous system; and sensory organ. Orthologous to human CBR3 (carbonyl reductase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in stomach adult (RPKM 117.7), colon adult (RPKM 22.3) and 8 other tissues See more
Orthologs
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Genomic context

See Cbr3 in Genome Data Viewer
Location:
16 C4; 16 54.58 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (93480107..93487879)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (93683219..93690991)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene carbonyl reductase 1 Neighboring gene carbonyl reductase 1B Neighboring gene STARR-positive B cell enhancer ABC_E5562 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:93711280-93711389 Neighboring gene STARR-positive B cell enhancer ABC_E1497 Neighboring gene STARR-seq mESC enhancer starr_41539 Neighboring gene predicted gene, 41501 Neighboring gene DOP1 leucine zipper like protein B Neighboring gene RIKEN cDNA 2310043M15 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC99956

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3-keto sterol reductase activity ISO
Inferred from Sequence Orthology
more info
 
enables NADPH binding ISO
Inferred from Sequence Orthology
more info
 
enables NADPH dehydrogenase (quinone) activity ISO
Inferred from Sequence Orthology
more info
 
enables carbonyl reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables carbonyl reductase (NADPH) activity ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cognition ISO
Inferred from Sequence Orthology
more info
 
involved_in phylloquinone catabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
carbonyl reductase [NADPH] 3
Names
NADPH-dependent carbonyl reductase 3
quinone reductase CBR3
NP_766635.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173047.3NP_766635.1  carbonyl reductase [NADPH] 3

    See identical proteins and their annotated locations for NP_766635.1

    Status: VALIDATED

    Source sequence(s)
    AK003232, AK028150, CF545530
    Consensus CDS
    CCDS28342.1
    UniProtKB/Swiss-Prot
    Q8K354
    Related
    ENSMUSP00000047712.7, ENSMUST00000039620.7
    Conserved Domains (1) summary
    cd05324
    Location:6277
    carb_red_PTCR-like_SDR_c; Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    93480107..93487879
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)