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CBR3 carbonyl reductase 3 [ Homo sapiens (human) ]

Gene ID: 874, updated on 23-Dec-2018

Summary

Official Symbol
CBR3provided by HGNC
Official Full Name
carbonyl reductase 3provided by HGNC
Primary source
HGNC:HGNC:1549
See related
Ensembl:ENSG00000159231 MIM:603608
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
hCBR3; SDR21C2; HEL-S-25
Summary
Carbonyl reductase 3 catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. The enzyme is classified as a monomeric NADPH-dependent oxidoreductase. CBR3 contains three exons spanning 11.2 kilobases and is closely linked to another carbonyl reductase gene - CBR1. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in esophagus (RPKM 6.1), skin (RPKM 5.7) and 22 other tissues See more
Orthologs

Genomic context

See CBR3 in Genome Data Viewer
Location:
21q22.12
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 21 NC_000021.9 (36134901..36146562)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (37506614..37518860)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene CBR3 antisense RNA 1 Neighboring gene mediator of cell motility 1 pseudogene 1 Neighboring gene ribosomal protein S9 pseudogene 1 Neighboring gene DOP1 leucine zipper like protein B Neighboring gene ribosomal protein L3 pseudogene 1 Neighboring gene serine and arginine rich splicing factor 9 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
3-keto sterol reductase activity IEA
Inferred from Electronic Annotation
more info
 
NADPH binding IDA
Inferred from Direct Assay
more info
PubMed 
carbonyl reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
carbonyl reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
PubMed 
carbonyl reductase (NADPH) activity TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cognition IMP
Inferred from Mutant Phenotype
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
phylloquinone catabolic process IEA
Inferred from Electronic Annotation
more info
 
xenobiotic metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular space HDA PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
carbonyl reductase [NADPH] 3
Names
NADPH-dependent carbonyl reductase 3
carbonyl reductase (NADPH) 3
epididymis secretory protein Li 25
short chain dehydrogenase/reductase family 21C member 2
NP_001227.1
XP_011528074.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052818.1 RefSeqGene

    Range
    5065..16662
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001236.4NP_001227.1  carbonyl reductase [NADPH] 3

    See identical proteins and their annotated locations for NP_001227.1

    Status: REVIEWED

    Source sequence(s)
    AB041012, BC002812
    Consensus CDS
    CCDS13642.1
    UniProtKB/Swiss-Prot
    O75828
    UniProtKB/TrEMBL
    V9HW40
    Related
    ENSP00000290354.5, ENST00000290354.5
    Conserved Domains (1) summary
    cd05324
    Location:6277
    carb_red_PTCR-like_SDR_c; Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p12 Primary Assembly

    Range
    36134901..36146562
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529772.2XP_011528074.1  carbonyl reductase [NADPH] 3 isoform X1

    Conserved Domains (1) summary
    cl21454
    Location:6131
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
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