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CCNI cyclin I [ Homo sapiens (human) ]

Gene ID: 10983, updated on 24-Nov-2020

Summary

Official Symbol
CCNIprovided by HGNC
Official Full Name
cyclin Iprovided by HGNC
Primary source
HGNC:HGNC:1595
See related
Ensembl:ENSG00000118816 MIM:618783
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CYI; CYC1; CCNI1
Summary
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin shows the highest similarity with cyclin G. The transcript of this gene was found to be expressed constantly during cell cycle progression. [provided by RefSeq, Jan 2017]
Expression
Ubiquitous expression in thyroid (RPKM 185.4), ovary (RPKM 178.6) and 25 other tissues See more
Orthologs

Genomic context

See CCNI in Genome Data Viewer
Location:
4q21.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (77047155..77075989, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (77968308..77998719, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene septin 11 Neighboring gene uncharacterized LOC105377291 Neighboring gene thioredoxin pseudogene 6 Neighboring gene uncharacterized LOC107986290 Neighboring gene ribosomal protein L7 pseudogene 17 Neighboring gene ubiquitin family domain containing 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
mitotic cell cycle phase transition IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spermatogenesis NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear membrane IEA
Inferred from Electronic Annotation
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001348132.2NP_001335061.1  cyclin-I isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), as well as variants 1 and 3, encodes isoform a.
    Source sequence(s)
    AC104771, AC111196
    Consensus CDS
    CCDS3580.1
    UniProtKB/Swiss-Prot
    Q14094
    UniProtKB/TrEMBL
    A0A024RDH0
    Conserved Domains (1) summary
    pfam00134
    Location:34142
    Cyclin_N; Cyclin, N-terminal domain
  2. NM_001348133.2NP_001335062.1  cyclin-I isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), as well as variants 1 and 2, encodes isoform a.
    Source sequence(s)
    AC104771, AC111196
    Consensus CDS
    CCDS3580.1
    UniProtKB/Swiss-Prot
    Q14094
    UniProtKB/TrEMBL
    A0A024RDH0
    Conserved Domains (1) summary
    pfam00134
    Location:34142
    Cyclin_N; Cyclin, N-terminal domain
  3. NM_001348134.2NP_001335063.1  cyclin-I isoform b

    Status: REVIEWED

    Source sequence(s)
    AC104771, AC111196
    UniProtKB/Swiss-Prot
    Q14094
    Conserved Domains (1) summary
    pfam00134
    Location:24128
    Cyclin_N; Cyclin, N-terminal domain
  4. NM_001348135.2NP_001335064.1  cyclin-I isoform c

    Status: REVIEWED

    Source sequence(s)
    AC104771, AC111196
    Conserved Domains (1) summary
    pfam00134
    Location:28112
    Cyclin_N; Cyclin, N-terminal domain
  5. NM_001348136.2NP_001335065.1  cyclin-I isoform d

    Status: REVIEWED

    Source sequence(s)
    AC104771, AC111196
    Conserved Domains (2) summary
    cl00050
    Location:4799
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
    cl25647
    Location:29171
    Cyclin_N2; N-terminal region of cyclin_N
  6. NM_001348137.2NP_001335066.1  cyclin-I isoform e

    Status: REVIEWED

    Source sequence(s)
    AC104771, AC111196
    Conserved Domains (1) summary
    cl00050
    Location:2888
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
  7. NM_001348138.2NP_001335067.1  cyclin-I isoform f

    Status: REVIEWED

    Source sequence(s)
    AC104771, AC111196
    Conserved Domains (1) summary
    cl00050
    Location:137
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
  8. NM_001348139.2NP_001335068.1  cyclin-I isoform g

    Status: REVIEWED

    Source sequence(s)
    AC104771, AC111196
  9. NM_001348140.2NP_001335069.1  cyclin-I isoform h

    Status: REVIEWED

    Source sequence(s)
    AC104771, AC111196
    Conserved Domains (1) summary
    pfam00134
    Location:28142
    Cyclin_N; Cyclin, N-terminal domain
  10. NM_006835.3NP_006826.1  cyclin-I isoform a

    See identical proteins and their annotated locations for NP_006826.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1, 2, and 3 all encode the same isoform (a).
    Source sequence(s)
    AC104771, AC111196
    Consensus CDS
    CCDS3580.1
    UniProtKB/Swiss-Prot
    Q14094
    UniProtKB/TrEMBL
    A0A024RDH0
    Related
    ENSP00000237654.4, ENST00000237654.9
    Conserved Domains (1) summary
    pfam00134
    Location:34142
    Cyclin_N; Cyclin, N-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    77047155..77075989 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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