cyclin-I isoform d [Homo sapiens]
cyclin family protein( domain architecture ID 1750054)
cyclin family protein may associate with and activate its cognate cyclin-dependent kinase
List of domain hits
Name | Accession | Description | Interval | E-value | |||
CYCLIN_SF super family | cl40454 | Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ... |
38-99 | 8.44e-38 | |||
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box. The actual alignment was detected with superfamily member cd20526: Pssm-ID: 477360 Cd Length: 99 Bit Score: 130.51 E-value: 8.44e-38
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CYCLIN_SF super family | cl40454 | Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ... |
103-175 | 7.06e-03 | |||
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box. The actual alignment was detected with superfamily member cd20529: Pssm-ID: 477360 [Multi-domain] Cd Length: 101 Bit Score: 35.42 E-value: 7.06e-03
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Name | Accession | Description | Interval | E-value | |||
CYCLIN_CCNI-like | cd20526 | cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because ... |
38-99 | 8.44e-38 | |||
cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because it is most abundant in post-mitotic cells. It is involved in various biological processes, such as cell survival, angiogenesis, cell differentiation, and cell cycle progression. CCNI contains a typical cyclin box near the N-terminus and a PEST sequence near the C-terminus. The cyclin box is a protein binding domain. Pssm-ID: 410230 Cd Length: 99 Bit Score: 130.51 E-value: 8.44e-38
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Cyclin_N | pfam00134 | Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ... |
47-99 | 1.54e-07 | |||
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain. Pssm-ID: 459686 [Multi-domain] Cd Length: 127 Bit Score: 49.44 E-value: 1.54e-07
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CYCLIN | smart00385 | domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ... |
41-93 | 5.46e-06 | |||
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control. Pssm-ID: 214641 [Multi-domain] Cd Length: 83 Bit Score: 43.74 E-value: 5.46e-06
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COG5024 | COG5024 | Cyclin [Cell division and chromosome partitioning]; |
29-171 | 6.98e-06 | |||
Cyclin [Cell division and chromosome partitioning]; Pssm-ID: 227357 [Multi-domain] Cd Length: 440 Bit Score: 47.46 E-value: 6.98e-06
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CYCLIN_CCNJ-like_rpt2 | cd20529 | second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ... |
103-175 | 7.06e-03 | |||
second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain. Pssm-ID: 410232 [Multi-domain] Cd Length: 101 Bit Score: 35.42 E-value: 7.06e-03
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Name | Accession | Description | Interval | E-value | |||
CYCLIN_CCNI-like | cd20526 | cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because ... |
38-99 | 8.44e-38 | |||
cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because it is most abundant in post-mitotic cells. It is involved in various biological processes, such as cell survival, angiogenesis, cell differentiation, and cell cycle progression. CCNI contains a typical cyclin box near the N-terminus and a PEST sequence near the C-terminus. The cyclin box is a protein binding domain. Pssm-ID: 410230 Cd Length: 99 Bit Score: 130.51 E-value: 8.44e-38
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CYCLIN_CCNG | cd20523 | cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 ... |
39-95 | 3.43e-18 | |||
cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 and CCNG2. CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. Members of this family contain one cyclin box. The cyclin box is a protein binding domain. Pssm-ID: 410227 Cd Length: 94 Bit Score: 78.16 E-value: 3.43e-18
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CYCLIN_CCNG2 | cd20584 | cyclin box found in cyclin-G2 (CCNG2) and similar proteins; CCNG2 may play a role in growth ... |
41-96 | 3.42e-13 | |||
cyclin box found in cyclin-G2 (CCNG2) and similar proteins; CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. CCNG2 contains one cyclin box. The cyclin box is a protein binding domain. Pssm-ID: 410287 Cd Length: 96 Bit Score: 64.48 E-value: 3.42e-13
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CYCLIN_CCNG1 | cd20583 | cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has ... |
38-97 | 4.93e-13 | |||
cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG1 contains one cyclin box. The cyclin box is a protein binding domain. Pssm-ID: 410286 Cd Length: 98 Bit Score: 64.07 E-value: 4.93e-13
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Cyclin_N | pfam00134 | Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ... |
47-99 | 1.54e-07 | |||
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain. Pssm-ID: 459686 [Multi-domain] Cd Length: 127 Bit Score: 49.44 E-value: 1.54e-07
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CYCLIN_ScCLN_like | cd20559 | cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar ... |
42-98 | 3.17e-07 | |||
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar proteins; ScCLNs, including ScCLN1-3, are essential for the control of the cell cycle at the G1/S (start) transition in Saccharomyces. ScCLN1 and ScCLN2 interact with the CDC28 protein kinase to form maturation promoting factor (MPF). ScCLN3 may be an upstream activator of the G1 cyclins that directly initiate G1/S transition. This family also includes Schizosaccharomyces pombe cyclin puc1, which contributes to negative regulation of the timing of sexual development in fission yeast, and functions at the transition between cycling and non-cycling cells. It interacts with protein kinase A. Members of this family contain one cyclin box. The cyclin box is a protein binding domain. Pssm-ID: 410262 [Multi-domain] Cd Length: 95 Bit Score: 47.76 E-value: 3.17e-07
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CYCLIN | smart00385 | domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ... |
41-93 | 5.46e-06 | |||
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control. Pssm-ID: 214641 [Multi-domain] Cd Length: 83 Bit Score: 43.74 E-value: 5.46e-06
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COG5024 | COG5024 | Cyclin [Cell division and chromosome partitioning]; |
29-171 | 6.98e-06 | |||
Cyclin [Cell division and chromosome partitioning]; Pssm-ID: 227357 [Multi-domain] Cd Length: 440 Bit Score: 47.46 E-value: 6.98e-06
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CYCLIN_CNTD2 | cd20542 | cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; ... |
40-99 | 1.84e-05 | |||
cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; CNTD2 is an atypical cyclin upregulated in human cancer tissues. It promotes cell proliferation and migration, as well as increases tumor growth in vivo. It can function as a prognostic factor and drug target. CNTD2 contains one cyclin box. The cyclin box is a protein binding domain. Pssm-ID: 410245 [Multi-domain] Cd Length: 96 Bit Score: 42.69 E-value: 1.84e-05
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CYCLIN_CCNE1_rpt1 | cd20579 | first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ... |
44-97 | 2.81e-05 | |||
first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain. Pssm-ID: 410282 [Multi-domain] Cd Length: 137 Bit Score: 43.33 E-value: 2.81e-05
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CYCLIN_CCNJ-like_rpt1 | cd20528 | first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ... |
47-97 | 3.43e-05 | |||
first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain. Pssm-ID: 410231 [Multi-domain] Cd Length: 103 Bit Score: 42.21 E-value: 3.43e-05
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CYCLIN_CCNE_rpt1 | cd20519 | first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ... |
44-97 | 3.78e-05 | |||
first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain. Pssm-ID: 410223 Cd Length: 131 Bit Score: 42.69 E-value: 3.78e-05
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CYCLIN_CCNH_rpt1 | cd20524 | first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ... |
40-99 | 3.72e-04 | |||
first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain. Pssm-ID: 410228 Cd Length: 150 Bit Score: 40.27 E-value: 3.72e-04
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CYCLIN_SF | cd00043 | Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ... |
40-90 | 1.79e-03 | |||
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box. Pssm-ID: 410207 [Multi-domain] Cd Length: 82 Bit Score: 36.62 E-value: 1.79e-03
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CYCLIN_CCNB1-like_rpt1 | cd20507 | first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ... |
32-96 | 3.65e-03 | |||
first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain. Pssm-ID: 410211 [Multi-domain] Cd Length: 130 Bit Score: 37.12 E-value: 3.65e-03
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CYCLIN_CCNE2_rpt1 | cd20580 | first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control ... |
44-97 | 5.96e-03 | |||
first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. CCNE2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain. Pssm-ID: 410283 [Multi-domain] Cd Length: 137 Bit Score: 36.75 E-value: 5.96e-03
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CYCLIN_CCNJ-like_rpt2 | cd20529 | second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ... |
103-175 | 7.06e-03 | |||
second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain. Pssm-ID: 410232 [Multi-domain] Cd Length: 101 Bit Score: 35.42 E-value: 7.06e-03
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Blast search parameters | ||||
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