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F11 coagulation factor XI [ Mus musculus (house mouse) ]

Gene ID: 109821, updated on 8-May-2024

Summary

Official Symbol
F11provided by MGI
Official Full Name
coagulation factor XIprovided by MGI
Primary source
MGI:MGI:99481
See related
Ensembl:ENSMUSG00000031645 AllianceGenome:MGI:99481
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FXI; PTA; Cf11; 1600027G01Rik
Summary
This gene encodes a glycoprotein coagulation factor that plays an important role in intrinsic pathway of blood coagulation and hemostasis. The encoded protein is an inactive zymogen that can be activated by coagulation factor XIIa, thrombin or factor XIa to generate active factor XIa protease. Mice lacking the encoded protein display a survival advantage during peritoneal sepsis and resist inflammation and bacterial accumulation upon infection with Listeria. [provided by RefSeq, Apr 2015]
Expression
Biased expression in liver E18 (RPKM 33.2), liver adult (RPKM 6.7) and 2 other tissues See more
Orthologs
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Genomic context

See F11 in Genome Data Viewer
Location:
8 B1.1; 8 25.14 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (45693696..45715092, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (45240659..45262055, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene melatonin receptor 1A Neighboring gene predicted gene, 30504 Neighboring gene STARR-seq mESC enhancer starr_21366 Neighboring gene predicted gene 6329 Neighboring gene STARR-seq mESC enhancer starr_21368 Neighboring gene STARR-seq mESC enhancer starr_21369 Neighboring gene kallikrein B, plasma 1 Neighboring gene cytochrome P450, family 4, subfamily v, polypeptide 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (7) 
  • Targeted (1)  1 citation

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables heparin binding IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables serine-type aminopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in blood coagulation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within hemostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in plasminogen activation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fibrinolysis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of blood coagulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
coagulation factor XI
Names
plasma thromboplastin antecedent
NP_001398594.1
NP_082342.1
XP_006509308.1
XP_011240474.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411665.1NP_001398594.1  coagulation factor XI isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC120003
  2. NM_028066.3NP_082342.1  coagulation factor XI isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_082342.1

    Status: REVIEWED

    Source sequence(s)
    AC120003
    Consensus CDS
    CCDS22274.1
    UniProtKB/Swiss-Prot
    Q91Y47, Q9DAT3
    Related
    ENSMUSP00000034064.4, ENSMUST00000034064.5
    Conserved Domains (3) summary
    smart00223
    Location:200283
    APPLE; APPLE domain
    smart00020
    Location:389617
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:390617
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    45693696..45715092 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509245.3XP_006509308.1  coagulation factor XI isoform X2

    Conserved Domains (3) summary
    smart00223
    Location:130213
    APPLE; APPLE domain
    cd00190
    Location:320547
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    cl00112
    Location:633
    PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
  2. XM_011242172.2XP_011240474.1  coagulation factor XI isoform X3

    Conserved Domains (2) summary
    smart00223
    Location:87170
    APPLE; APPLE domain
    cd00190
    Location:277504
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RNA

  1. XR_003947216.1 RNA Sequence

    Related
    ENSMUST00000210622.2