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COPS6 COP9 signalosome subunit 6 [ Homo sapiens (human) ]

Gene ID: 10980, updated on 1-Jun-2020

Summary

Official Symbol
COPS6provided by HGNC
Official Full Name
COP9 signalosome subunit 6provided by HGNC
Primary source
HGNC:HGNC:21749
See related
Ensembl:ENSG00000168090 MIM:614729
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CSN6; MOV34-34KD
Summary
The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein belongs to translation initiation factor 3 (eIF3) superfamily. It is involved in the regulation of cell cycle and likely to be a cellular cofactor for HIV-1 accessory gene product Vpr. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in esophagus (RPKM 33.2), testis (RPKM 32.7) and 25 other tissues See more
Orthologs

Genomic context

See COPS6 in Genome Data Viewer
Location:
7q22.1
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (100088969..100092187)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (99686583..99689823)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene zinc finger with KRAB and SCAN domains 1 Neighboring gene zinc finger and SCAN domain containing 21 Neighboring gene zinc finger protein 3 Neighboring gene microRNA 25 Neighboring gene microRNA 93 Neighboring gene minichromosome maintenance complex component 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr is identified to have a physical interaction with COP9 constitutive photomorphogenic homolog subunit 6 (COPS6) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
vpr Interaction of HIV-1 Vpr and hVIP/mov34 is associated with the Vpr mediated inhibition of maturation promoting factor (MPF), a protein kinase complex composed of p34cdc2 and cyclin B PubMed
vpr Interaction of HIV-1 Vpr and hVIP/mov34 may be involved in the activation of glucocorticoid receptor by Vpr PubMed
vpr Interaction of HIV-1 Vpr with hVIP/mov34 is associated with the cell cycle arrest function of Vpr, suggesting hVIP/mov34 is a cellular cofactor for Vpr PubMed
vpr The C-terminal portion of HIV-1 Vpr directly binds the C-terminal region of hVIP/mov34 (amino acids 251-341) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
nucleotide-excision repair, DNA damage recognition TAS
Traceable Author Statement
more info
 
post-translational protein modification TAS
Traceable Author Statement
more info
 
protein deneddylation IDA
Inferred from Direct Assay
more info
PubMed 
transcription-coupled nucleotide-excision repair TAS
Traceable Author Statement
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
COP9 signalosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
COP9 signalosome IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
COP9 signalosome complex subunit 6
Names
COP9 constitutive photomorphogenic homolog subunit 6
H_NH0506M12.12
JAB1-containing signalosome subunit 6
MOV34 homolog, 34 kD
SGN6
hVIP
vpr-interacting protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046973.1 RefSeqGene

    Range
    5010..8228
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_006833.5NP_006824.2  COP9 signalosome complex subunit 6

    See identical proteins and their annotated locations for NP_006824.2

    Status: REVIEWED

    Source sequence(s)
    BC002520, CB990467, CD367717
    Consensus CDS
    CCDS5682.1
    UniProtKB/Swiss-Prot
    Q7L5N1
    Related
    ENSP00000304102.3, ENST00000303904.8
    Conserved Domains (1) summary
    cd08063
    Location:39321
    MPN_CSN6; Mpr1p, Pad1p N-terminal (MPN) domains without catalytic isopeptidase activity, found in COP9 signalosome complex subunit 6

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    100088969..100092187
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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