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Blvra biliverdin reductase A [ Mus musculus (house mouse) ]

Gene ID: 109778, updated on 1-Mar-2024

Summary

Official Symbol
Blvraprovided by MGI
Official Full Name
biliverdin reductase Aprovided by MGI
Primary source
MGI:MGI:88170
See related
Ensembl:ENSMUSG00000001999 AllianceGenome:MGI:88170
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Blvr; 0610006A11Rik; 2500001N03Rik
Summary
Enables biliverdin reductase (NAD(P)+) activity. Predicted to be involved in heme catabolic process. Predicted to be located in cytosol. Is expressed in decidua; myometrium; placenta; and spongiotrophoblast. Orthologous to human BLVRA (biliverdin reductase A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 12.0), bladder adult (RPKM 10.9) and 26 other tissues See more
Orthologs
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Genomic context

See Blvra in Genome Data Viewer
Location:
2 F1; 2 61.76 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (126912549..126939004)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (127070629..127097084)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 52496 Neighboring gene STARR-seq mESC enhancer starr_05618 Neighboring gene STARR-positive B cell enhancer ABC_E9531 Neighboring gene adaptor-related protein complex AP-4, epsilon 1 Neighboring gene STARR-seq mESC enhancer starr_05619 Neighboring gene STARR-positive B cell enhancer ABC_E3399 Neighboring gene predicted gene, 31414 Neighboring gene predicted gene, 39922 Neighboring gene non-SMC condensin I complex, subunit H Neighboring gene STARR-positive B cell enhancer ABC_E3400

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables biliberdin reductase NAD+ activity ISO
Inferred from Sequence Orthology
more info
 
enables biliverdin reductase (NAD(P)+) activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables biliverdin reductase (NAD(P)+) activity IDA
Inferred from Direct Assay
more info
PubMed 
enables biliverdin reductase (NAD(P)+) activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables biliverdin reductase (NADP+) activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within heme catabolic process ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in heme catabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
biliverdin reductase A
Names
BVR A
biliverdin-IX alpha-reductase
NP_080954.4
XP_006498632.1
XP_006498634.1
XP_006498635.1
XP_006498636.1
XP_030102511.1
XP_030102519.1
XP_036013445.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026678.4NP_080954.4  biliverdin reductase A

    See identical proteins and their annotated locations for NP_080954.4

    Status: VALIDATED

    Source sequence(s)
    BC052146, BY073963, CA983696
    Consensus CDS
    CCDS16692.1
    UniProtKB/Swiss-Prot
    Q3T9C6, Q80WR6, Q9CY64, Q9DD21
    Related
    ENSMUSP00000002064.9, ENSMUST00000002064.15
    Conserved Domains (2) summary
    pfam01408
    Location:18121
    GFO_IDH_MocA; Oxidoreductase family, NAD-binding Rossmann fold
    pfam09166
    Location:132242
    Biliv-reduc_cat; Biliverdin reductase, catalytic

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    126912549..126939004
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498573.1XP_006498636.1  biliverdin reductase A isoform X3

    Conserved Domains (1) summary
    pfam09166
    Location:34144
    Biliv-reduc_cat; Biliverdin reductase, catalytic
  2. XM_030246659.1XP_030102519.1  biliverdin reductase A isoform X3

    Conserved Domains (1) summary
    pfam09166
    Location:34144
    Biliv-reduc_cat; Biliverdin reductase, catalytic
  3. XM_006498571.3XP_006498634.1  biliverdin reductase A isoform X2

    See identical proteins and their annotated locations for XP_006498634.1

    UniProtKB/Swiss-Prot
    Q3T9C6, Q80WR6, Q9CY64, Q9DD21
    Conserved Domains (2) summary
    pfam01408
    Location:18121
    GFO_IDH_MocA; Oxidoreductase family, NAD-binding Rossmann fold
    pfam09166
    Location:132242
    Biliv-reduc_cat; Biliverdin reductase, catalytic
  4. XM_030246651.1XP_030102511.1  biliverdin reductase A isoform X2

    UniProtKB/Swiss-Prot
    Q3T9C6, Q80WR6, Q9CY64, Q9DD21
    Conserved Domains (2) summary
    pfam01408
    Location:18121
    GFO_IDH_MocA; Oxidoreductase family, NAD-binding Rossmann fold
    pfam09166
    Location:132242
    Biliv-reduc_cat; Biliverdin reductase, catalytic
  5. XM_006498569.4XP_006498632.1  biliverdin reductase A isoform X1

    Conserved Domains (2) summary
    pfam01408
    Location:60163
    GFO_IDH_MocA; Oxidoreductase family, NAD-binding Rossmann fold
    pfam09166
    Location:174284
    Biliv-reduc_cat; Biliverdin reductase, catalytic
  6. XM_036157552.1XP_036013445.1  biliverdin reductase A isoform X3

    Conserved Domains (1) summary
    pfam09166
    Location:34144
    Biliv-reduc_cat; Biliverdin reductase, catalytic
  7. XM_006498572.5XP_006498635.1  biliverdin reductase A isoform X2

    See identical proteins and their annotated locations for XP_006498635.1

    UniProtKB/Swiss-Prot
    Q3T9C6, Q80WR6, Q9CY64, Q9DD21
    Conserved Domains (2) summary
    pfam01408
    Location:18121
    GFO_IDH_MocA; Oxidoreductase family, NAD-binding Rossmann fold
    pfam09166
    Location:132242
    Biliv-reduc_cat; Biliverdin reductase, catalytic