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BLVRA biliverdin reductase A [ Homo sapiens (human) ]

Gene ID: 644, updated on 11-Sep-2019

Summary

Official Symbol
BLVRAprovided by HGNC
Official Full Name
biliverdin reductase Aprovided by HGNC
Primary source
HGNC:HGNC:1062
See related
Ensembl:ENSG00000106605 MIM:109750
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BVR; BLVR; BVRA
Summary
The protein encoded by this gene belongs to the biliverdin reductase family, members of which catalyze the conversion of biliverdin to bilirubin in the presence of NADPH or NADH. Mutations in this gene are associated with hyperbiliverdinemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2011]
Expression
Ubiquitous expression in spleen (RPKM 33.2), lung (RPKM 23.1) and 25 other tissues See more
Orthologs

Genomic context

See BLVRA in Genome Data Viewer
Location:
7p13
Exon count:
12
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (43758122..43807342)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (43798272..43846941)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene serine/threonine kinase 17a Neighboring gene cytochrome c oxidase assembly factor 1 homolog Neighboring gene NFE2L2 motif-containing MPRA enhancer 272 Neighboring gene uncharacterized LOC107986727 Neighboring gene uncharacterized LOC102724946 Neighboring gene Sharpr-MPRA regulatory region 4653 Neighboring gene URGCP-MRPS24 readthrough Neighboring gene mitochondrial ribosomal protein S24

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Heme degradation, organism-specific biosystem (from REACTOME)
    Heme degradation, organism-specific biosystemMost of the heme degraded in humans comes from hemoglobin. Approximately 6-8 grams of hemoglobin is degraded daily which is equivalent to approximately 300 milligrams of heme per day. Heme is not rec...
  • Metabolic pathways, organism-specific biosystem (from KEGG)
    Metabolic pathways, organism-specific biosystem
    Metabolic pathways
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of porphyrins, organism-specific biosystem (from REACTOME)
    Metabolism of porphyrins, organism-specific biosystemPorphyrins are heterocyclic macrocycles, consisting of four pyrrole subunits (tetrapyrrole) linked by four methine (=CH-) bridges. The extensive conjugated porphyrin macrocycle is chromatic and the n...
  • Porphyrin and chlorophyll metabolism, organism-specific biosystem (from KEGG)
    Porphyrin and chlorophyll metabolism, organism-specific biosystem
    Porphyrin and chlorophyll metabolism
  • Porphyrin and chlorophyll metabolism, conserved biosystem (from KEGG)
    Porphyrin and chlorophyll metabolism, conserved biosystem
    Porphyrin and chlorophyll metabolism
  • heme degradation, organism-specific biosystem (from BIOCYC)
    heme degradation, organism-specific biosystemThe heme degradation pathway in animals ensures the recycling of iron. The first enzyme in this pathway, : HS02027-MONOMER, catayzes the opening of the tetrapyrrole macrocycle of : PROTOHEME, forming...
  • heme degradation, conserved biosystem (from BIOCYC)
    heme degradation, conserved biosystemThe heme degradation pathway in animals ensures the recycling of iron. The first enzyme in this pathway, |FRAME: HS02027-MONOMER|, catayzes the opening of the tetrapyrrole macrocycle of |FRAME: Heme-...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
biliverdin reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
biliverdin reductase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
heme catabolic process TAS
Traceable Author Statement
more info
PubMed 
oxidation-reduction process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 

General protein information

Preferred Names
biliverdin reductase A
Names
BVR A
biliverdin-IX alpha-reductase
testis tissue sperm-binding protein Li 61n
NP_000703.2
NP_001240752.1
XP_011513776.1
XP_016868009.1
XP_024302635.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_031876.1 RefSeqGene

    Range
    5001..53670
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000712.4NP_000703.2  biliverdin reductase A precursor

    See identical proteins and their annotated locations for NP_000703.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BM710258, U34877, X93086
    Consensus CDS
    CCDS5472.1
    UniProtKB/Swiss-Prot
    P53004
    UniProtKB/TrEMBL
    A0A140VJF4
    Related
    ENSP00000265523.4, ENST00000265523.9
    Conserved Domains (2) summary
    pfam01408
    Location:18125
    GFO_IDH_MocA; Oxidoreductase family, NAD-binding Rossmann fold
    pfam09166
    Location:133242
    Biliv-reduc_cat; Biliverdin reductase, catalytic
  2. NM_001253823.1NP_001240752.1  biliverdin reductase A precursor

    See identical proteins and their annotated locations for NP_001240752.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an additional 5' non-coding exon compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK291862, BM710258, CA418616
    Consensus CDS
    CCDS5472.1
    UniProtKB/Swiss-Prot
    P53004
    UniProtKB/TrEMBL
    A0A140VJF4
    Related
    ENSP00000385757.1, ENST00000402924.5
    Conserved Domains (2) summary
    pfam01408
    Location:18125
    GFO_IDH_MocA; Oxidoreductase family, NAD-binding Rossmann fold
    pfam09166
    Location:133242
    Biliv-reduc_cat; Biliverdin reductase, catalytic

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    43758122..43807342
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515474.3XP_011513776.1  biliverdin reductase A isoform X1

    See identical proteins and their annotated locations for XP_011513776.1

    UniProtKB/Swiss-Prot
    P53004
    UniProtKB/TrEMBL
    A0A140VJF4
    Conserved Domains (2) summary
    pfam01408
    Location:18125
    GFO_IDH_MocA; Oxidoreductase family, NAD-binding Rossmann fold
    pfam09166
    Location:133242
    Biliv-reduc_cat; Biliverdin reductase, catalytic
  2. XM_024446867.1XP_024302635.1  biliverdin reductase A isoform X1

    Conserved Domains (2) summary
    pfam01408
    Location:18125
    GFO_IDH_MocA; Oxidoreductase family, NAD-binding Rossmann fold
    pfam09166
    Location:133242
    Biliv-reduc_cat; Biliverdin reductase, catalytic
  3. XM_017012520.2XP_016868009.1  biliverdin reductase A isoform X1

    UniProtKB/Swiss-Prot
    P53004
    UniProtKB/TrEMBL
    A0A140VJF4
    Conserved Domains (2) summary
    pfam01408
    Location:18125
    GFO_IDH_MocA; Oxidoreductase family, NAD-binding Rossmann fold
    pfam09166
    Location:133242
    Biliv-reduc_cat; Biliverdin reductase, catalytic
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