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YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta [ Homo sapiens (human) ]

Gene ID: 10971, updated on 29-Mar-2023


Official Symbol
YWHAQprovided by HGNC
Official Full Name
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein thetaprovided by HGNC
Primary source
See related
Ensembl:ENSG00000134308 MIM:609009; AllianceGenome:HGNC:12854
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
1C5; HS1; 14-3-3
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease. [provided by RefSeq, Jul 2008]
Ubiquitous expression in brain (RPKM 160.3), endometrium (RPKM 117.5) and 25 other tissues See more
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Genomic context

See YWHAQ in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (9583967..9630997, complement)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (9609000..9656011, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (9724096..9771126, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 1969 Neighboring gene uncharacterized LOC101929643 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:9769712-9770614 Neighboring gene uncharacterized LOC105373418 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:9789200-9789709

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


GeneRIFs: Gene References Into Functions

What's a GeneRIF?


EBI GWAS Catalog

Heritability of submaximal exercise heart rate response to exercise training is accounted for by nine SNPs.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Treatment of cells with dsRNA against 14-3-3tau enhances gp120-mediated dephosphorylation of Bad and its association with Bcl-XL in mitochondria, and accelerates gp120-induced apoptosis PubMed
env HIV-1 gp120 increases the expression of 14-3-3tau in cells. The binding of gp120 to CXCR4 induces cell apoptosis through decreased binding of 14-3-3tau to the pro-apoptotic molecule, Bad PubMed
Vpr vpr Vpr-induced cell cycle G2/M arrest reveals a dramatic increase in the amount of Cdk1, Cdc25C, and CyclinB1 bound to 14-3-3 theta PubMed
vpr HIV-1 Vpr inhibits insulin-induced association of 14-3-3 and Foxo3a in HeLa cells PubMed
vpr Yeast two-hybrid assays show that the C-terminal half (residues 141-244) of 14-3-3 tau binds to HIV-1 Vpr; Vpr supports triple complex formation with 14-3-3 tau and Cdc25C PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem


Products Interactant Other Gene Complex Source Pubs Description

General gene information



Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 14-3-3 protein binding IEA
Inferred from Electronic Annotation
more info
enables identical protein binding IPI
Inferred from Physical Interaction
more info
enables protein binding IPI
Inferred from Physical Interaction
more info
enables protein domain specific binding IEA
Inferred from Electronic Annotation
more info
enables transmembrane transporter binding IEA
Inferred from Electronic Annotation
more info
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
located_in cytoplasm IDA
Inferred from Direct Assay
more info
located_in cytosol TAS
Traceable Author Statement
more info
located_in extracellular exosome HDA PubMed 
located_in focal adhesion HDA PubMed 
located_in membrane HDA PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
located_in synapse IEA
Inferred from Electronic Annotation
more info

General protein information

Preferred Names
14-3-3 protein theta
14-3-3 protein T-cell
14-3-3 protein tau
14-3-3 theta
protein, theta
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006826.4NP_006817.1  14-3-3 protein theta

    See identical proteins and their annotated locations for NP_006817.1

    Status: REVIEWED

    Source sequence(s)
    AA729400, BC050601, BC093019
    Consensus CDS
    P27348, Q9UP48
    ENSP00000238081.3, ENST00000238081.8
    Conserved Domains (1) summary
    14-3-3_theta; 14-3-3 theta/tau (theta in mice, tau in human), an isoform of 14-3-3 protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly


  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    9583967..9630997 complement
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0


  1. NC_060926.1 Alternate T2T-CHM13v2.0

    9609000..9656011 complement
    GenBank, FASTA, Sequence Viewer (Graphics)