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CKAP4 cytoskeleton associated protein 4 [ Homo sapiens (human) ]

Gene ID: 10970, updated on 3-Dec-2023

Summary

Official Symbol
CKAP4provided by HGNC
Official Full Name
cytoskeleton associated protein 4provided by HGNC
Primary source
HGNC:HGNC:16991
See related
Ensembl:ENSG00000136026 MIM:618595; AllianceGenome:HGNC:16991
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p63; CLIMP63; CLIMP-63; ERGIC-63
Summary
Enables RNA binding activity. Located in several cellular components, including lipid droplet; nuclear speck; and rough endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bone marrow (RPKM 41.9), placenta (RPKM 30.9) and 25 other tissues See more
Orthologs
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Genomic context

See CKAP4 in Genome Data Viewer
Location:
12q23.3
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (106237881..106248020, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (106200876..106211009, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (106631659..106641798, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene NUAK family kinase 1 Neighboring gene uncharacterized LOC124903007 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:106523693-106524442 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:106524443-106525192 Neighboring gene Sharpr-MPRA regulatory region 11062 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:106526214-106527056 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:106527057-106527900 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:106527901-106528743 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:106531161-106531662 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:106534054-106534673 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:106541977-106542476 Neighboring gene thyroid hormone receptor interactor 11 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:106581756-106582590 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:106605939-106606439 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6945 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4812 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4813 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4814 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4815 Neighboring gene uncharacterized LOC124903008 Neighboring gene RNA, U7 small nuclear 94 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 is identified to have a physical interaction with cytoskeleton-associated protein 4 (CKAP4) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 is identified to have a physical interaction with cytoskeleton-associated protein 4 (CKAP4) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC99554

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in azurophil granule membrane TAS
Traceable Author Statement
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular exosome HDA PubMed 
located_in lamellar body TAS
Traceable Author Statement
more info
 
located_in lipid droplet IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane TAS
Traceable Author Statement
more info
PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
is_active_in rough endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in rough endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in specific granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
cytoskeleton-associated protein 4
Names
63 kDa membrane protein
63-kDa cytoskeleton-linking membrane protein
transmembrane protein (63kD), endoplasmic reticulum/Golgi intermediate compartment
type-II transmembrane protein p63

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006825.4NP_006816.2  cytoskeleton-associated protein 4

    See identical proteins and their annotated locations for NP_006816.2

    Status: VALIDATED

    Source sequence(s)
    AC079174, X69910
    Consensus CDS
    CCDS9103.1
    UniProtKB/Swiss-Prot
    Q07065, Q504S5, Q53ES6
    UniProtKB/TrEMBL
    B3KVX6
    Related
    ENSP00000367265.4, ENST00000378026.5
    Conserved Domains (2) summary
    TIGR00344
    Location:487560
    alaS; alanine--tRNA ligase
    TIGR02168
    Location:149459
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    106237881..106248020 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    106200876..106211009 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)