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EBNA1BP2 EBNA1 binding protein 2 [ Homo sapiens (human) ]

Gene ID: 10969, updated on 7-Jun-2020

Summary

Official Symbol
EBNA1BP2provided by HGNC
Official Full Name
EBNA1 binding protein 2provided by HGNC
Primary source
HGNC:HGNC:15531
See related
Ensembl:ENSG00000117395 MIM:614443
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P40; EBP2; NOBP
Expression
Ubiquitous expression in testis (RPKM 24.1), thyroid (RPKM 21.0) and 25 other tissues See more
Orthologs

Genomic context

See EBNA1BP2 in Genome Data Viewer
Location:
1p34.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (43164174..43172570, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (43629845..43638241, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 880, pseudogene Neighboring gene family with sequence similarity 183 member A Neighboring gene uncharacterized LOC105378685 Neighboring gene microRNA 6733 Neighboring gene cilia and flagella associated protein 57 Neighboring gene RNA, 5S ribosomal pseudogene 46 Neighboring gene transmembrane protein 125

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human EBNA1 binding protein 2 (EBNA1BP2) at amino acid residues 212-213 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
rRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribosomal large subunit biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nuclear periphery IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
preribosome, large subunit precursor IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
probable rRNA-processing protein EBP2
Names
nuclear FGF3 binding protein
nucleolar protein p40
nucleolar protein p40; homolog of yeast EBNA1-binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159936.1NP_001153408.1  probable rRNA-processing protein EBP2 isoform 1

    See identical proteins and their annotated locations for NP_001153408.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC009175, CN390915, R49106, U86602, Z40246
    Consensus CDS
    CCDS53308.1
    UniProtKB/Swiss-Prot
    Q99848
    UniProtKB/TrEMBL
    H7C2Q8
    Related
    ENSP00000407323.2, ENST00000431635.6
    Conserved Domains (1) summary
    pfam05890
    Location:75350
    Ebp2; Eukaryotic rRNA processing protein EBP2
  2. NM_006824.3NP_006815.2  probable rRNA-processing protein EBP2 isoform 2

    See identical proteins and their annotated locations for NP_006815.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    BC009175, BM791254, U86602
    Consensus CDS
    CCDS478.1
    UniProtKB/Swiss-Prot
    Q99848
    UniProtKB/TrEMBL
    Q6IB29
    Related
    ENSP00000236051.2, ENST00000236051.2
    Conserved Domains (1) summary
    pfam05890
    Location:20295
    Ebp2; Eukaryotic rRNA processing protein EBP2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    43164174..43172570 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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