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MLLT11 MLLT11 transcription factor 7 cofactor [ Homo sapiens (human) ]

Gene ID: 10962, updated on 1-Jun-2020

Summary

Official Symbol
MLLT11provided by HGNC
Official Full Name
MLLT11 transcription factor 7 cofactorprovided by HGNC
Primary source
HGNC:HGNC:16997
See related
Ensembl:ENSG00000213190 MIM:604684
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AF1Q
Summary
The gene variously symbolized ALL1, HRX, or MLL located on 11q23 has been demonstrated to be fused with a number of translocation partners in cases of leukemia. t(1;11)(q21;q23) translocations that fused the MLL gene to a gene on chromosomal band 1q21 in 2 infants with acute myelomonocytic leukemia have been demonstrated. The N-terminal portion of the MLL gene is critical for leukemogenesis in translocations involving band 11q23. This gene encodes 90 amino acids. It was found to be highly expressed in the thymus but not in peripheral lymphoid tissues. In contrast to its restricted distribution in normal hematopoietic tissue, this gene was expressed in all leukemic cell lines tested. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 95.2), heart (RPKM 17.4) and 3 other tissues See more
Orthologs

Genomic context

See MLLT11 in Genome Data Viewer
Location:
1q21.3
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (151060397..151069544)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (151032151..151040973)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene BCL2 interacting protein like Neighboring gene chromosome 1 open reading frame 56 Neighboring gene CDC42 small effector 1 Neighboring gene GA binding protein transcription factor subunit beta 2 Neighboring gene ribosomal protein S29 pseudogene 29 Neighboring gene semaphorin 6C

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
microtubule organizing center IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
protein AF1q
Names
ALL1 fused gene from chromosome 1q
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006818.4NP_006809.1  protein AF1q

    See identical proteins and their annotated locations for NP_006809.1

    Status: REVIEWED

    Source sequence(s)
    AL590133
    Consensus CDS
    CCDS982.1
    UniProtKB/Swiss-Prot
    Q13015
    UniProtKB/TrEMBL
    Q6FGF7
    Related
    ENSP00000357917.3, ENST00000368921.5
    Conserved Domains (1) summary
    pfam15017
    Location:779
    WRNPLPNID; Putative WW-binding domain and destruction box

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    151060397..151069544
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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