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Mllt11 myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11 [ Mus musculus (house mouse) ]

Gene ID: 56772, updated on 4-Nov-2022

Summary

Official Symbol
Mllt11provided by MGI
Official Full Name
myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11provided by MGI
Primary source
MGI:MGI:1929671
See related
Ensembl:ENSMUSG00000053192 AllianceGenome:MGI:1929671
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Af1q; Zfp692
Summary
Predicted to be involved in several processes, including apoptotic signaling pathway; positive regulation of mitochondrial depolarization; and positive regulation of release of cytochrome c from mitochondria. Located in cytoplasm. Is expressed in several structures, including gut; liver; nervous system; secondary oocyte; and sensory organ. Orthologous to human MLLT11 (MLLT11 transcription factor 7 cofactor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 117.9), whole brain E14.5 (RPKM 86.7) and 6 other tissues See more
Orthologs
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Genomic context

See Mllt11 in Genome Data Viewer
Location:
3; 3 F2.1
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (95125855..95136943, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (95218544..95229632, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C Neighboring gene GA repeat binding protein, beta 2 Neighboring gene predicted gene, 16740 Neighboring gene CDC42 small effector 1 Neighboring gene predicted gene 128 Neighboring gene BCL2/adenovirus E1B 19kD interacting protein like Neighboring gene prune exopolyphosphatase Neighboring gene MINDY lysine 48 deubiquitinase 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein AF1q
Names
ALL1-fused gene from chromosome 1q
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
zinc finger protein 692

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411090.1NP_001398019.1  protein AF1q

    Status: VALIDATED

    Source sequence(s)
    AC140190
    UniProtKB/Swiss-Prot
    P97783
    UniProtKB/TrEMBL
    Q543U0
  2. NM_001411091.1NP_001398020.1  protein AF1q

    Status: VALIDATED

    Source sequence(s)
    AC140190
    UniProtKB/Swiss-Prot
    P97783
    UniProtKB/TrEMBL
    Q543U0
  3. NM_001411092.1NP_001398021.1  protein AF1q

    Status: VALIDATED

    Source sequence(s)
    AC140190
    UniProtKB/Swiss-Prot
    P97783
    UniProtKB/TrEMBL
    Q543U0
  4. NM_019914.5NP_064298.1  protein AF1q

    See identical proteins and their annotated locations for NP_064298.1

    Status: VALIDATED

    Source sequence(s)
    AC140190
    Consensus CDS
    CCDS38544.1
    UniProtKB/Swiss-Prot
    P97783
    UniProtKB/TrEMBL
    Q543U0
    Related
    ENSMUSP00000066448.6, ENSMUST00000065482.6
    Conserved Domains (1) summary
    pfam15017
    Location:779
    WRNPLPNID; Putative WW-binding domain and destruction box

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    95125855..95136943 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252728.1XP_030108588.1  protein AF1q isoform X1

    Related
    ENSMUSP00000143755.2, ENSMUST00000196025.5
    Conserved Domains (1) summary
    pfam15017
    Location:779
    WRNPLPNID; Putative WW-binding domain and destruction box