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ERP29 endoplasmic reticulum protein 29 [ Homo sapiens (human) ]

Gene ID: 10961, updated on 7-Dec-2018

Summary

Official Symbol
ERP29provided by HGNC
Official Full Name
endoplasmic reticulum protein 29provided by HGNC
Primary source
HGNC:HGNC:13799
See related
Ensembl:ENSG00000089248 MIM:602287
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ERp28; ERp31; PDIA9; PDI-DB; C12orf8; HEL-S-107
Summary
This gene encodes a protein which localizes to the lumen of the endoplasmic reticulum (ER). It is a member of the protein disulfide isomerase (PDI) protein family but lacks an active thioredoxin motif, suggesting that this protein does not function as a disulfide isomerase. The canonical protein dimerizes and is thought to play a role in the processing of secretory proteins within the ER. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]
Expression
Ubiquitous expression in bone marrow (RPKM 73.5), prostate (RPKM 67.8) and 25 other tissues See more
Orthologs

Genomic context

See ERP29 in Genome Data Viewer
Location:
12q24.13
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (112013340..112023220)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (112451152..112461024)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene transmembrane protein 116 Neighboring gene solute carrier family 25 member 3 pseudogene 2 Neighboring gene immediate early response 3 interacting protein 1 pseudogene Neighboring gene N(alpha)-acetyltransferase 25, NatB auxiliary subunit Neighboring gene microRNA 3657 Neighboring gene TRAF-type zinc finger domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with ERP29; predicted interaction to be within the endoplasmic reticulum and function as chaperone for endoplasmic reticulum-associated degradation PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
    Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
  • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
    Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chaperone binding ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT protein disulfide isomerase activity IKR
Inferred from Key Residues
more info
PubMed 
protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
activation of MAPK activity IDA
Inferred from Direct Assay
more info
PubMed 
intracellular protein transport NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein secretion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein folding NAS
Non-traceable Author Statement
more info
PubMed 
protein secretion IEA
Inferred from Electronic Annotation
more info
 
protein unfolding NAS
Non-traceable Author Statement
more info
PubMed 
regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum lumen NAS
Non-traceable Author Statement
more info
PubMed 
melanosome IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
smooth endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
transport vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
endoplasmic reticulum resident protein 29
Names
endoplasmic reticulum lumenal protein ERp28
endoplasmic reticulum resident protein 28
endoplasmic reticulum resident protein 31
epididymis secretory protein Li 107
protein disulfide isomerase family A, member 9

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034025.1NP_001029197.1  endoplasmic reticulum resident protein 29 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the coding region that results in a frameshift and an early stop codon, compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AA412124, AC073575
    Consensus CDS
    CCDS44977.1
    UniProtKB/Swiss-Prot
    P30040
    Related
    ENSP00000412083.1, ENST00000455836.1
    Conserved Domains (1) summary
    cl00388
    Location:3350
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
  2. NM_006817.4NP_006808.1  endoplasmic reticulum resident protein 29 isoform 1 precursor

    See identical proteins and their annotated locations for NP_006808.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC073575, BC101493
    Consensus CDS
    CCDS9158.1
    UniProtKB/Swiss-Prot
    P30040
    UniProtKB/TrEMBL
    V9HW71
    Related
    ENSP00000261735.3, ENST00000261735.3
    Conserved Domains (2) summary
    cd03007
    Location:36149
    PDI_a_ERp29_N; PDIa family, endoplasmic reticulum protein 29 (ERp29) subfamily; ERp29 is a ubiquitous ER-resident protein expressed in high levels in secretory cells. It forms homodimers and higher oligomers in vitro and in vivo. It contains a redox inactive TRX-like ...
    pfam07749
    Location:156251
    ERp29; Endoplasmic reticulum protein ERp29, C-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

    Range
    112013340..112023220
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018720.1XP_016874209.1  endoplasmic reticulum resident protein 29 isoform X1

    UniProtKB/TrEMBL
    F8VY02
    Related
    ENSP00000449018.1, ENST00000546477.1
    Conserved Domains (2) summary
    pfam07749
    Location:55150
    ERp29; Endoplasmic reticulum protein ERp29, C-terminal domain
    cl00388
    Location:148
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
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