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PNRC1 proline rich nuclear receptor coactivator 1 [ Homo sapiens (human) ]

Gene ID: 10957, updated on 2-Oct-2018

Summary

Official Symbol
PNRC1provided by HGNC
Official Full Name
proline rich nuclear receptor coactivator 1provided by HGNC
Primary source
HGNC:HGNC:17278
See related
Ensembl:ENSG00000146278 MIM:606714; Vega:OTTHUMG00000015191
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B4-2; PRR2; PROL2; PNAS-145
Expression
Ubiquitous expression in bone marrow (RPKM 61.8), adrenal (RPKM 44.5) and 25 other tissues See more
Orthologs

Genomic context

See PNRC1 in Genome Data Viewer
Location:
6q15
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (89080710..89085160)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (89790429..89794879)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene adaptor related protein complex 4 sigma 1 subunit pseudogene Neighboring gene RNA, U2 small nuclear 61, pseudogene Neighboring gene RNA, 7SL, cytoplasmic 336, pseudogene Neighboring gene peptidase M20 domain containing 2 Neighboring gene serine and arginine rich splicing factor 12

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of proline-rich nuclear receptor coactivator 1 (PNRC1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
proline-rich nuclear receptor coactivator 1
Names
proline rich 2 protein
proline-rich polypeptide 2
proline-rich protein 2
proline-rich protein with nuclear targeting signal
protein B4-2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006813.2NP_006804.1  proline-rich nuclear receptor coactivator 1

    See identical proteins and their annotated locations for NP_006804.1

    Status: VALIDATED

    Source sequence(s)
    AK130046, AK312665, DB494998, U03105
    Consensus CDS
    CCDS5018.1
    UniProtKB/Swiss-Prot
    Q12796
    Related
    ENSP00000336931.3, OTTHUMP00000016843, ENST00000336032.3, OTTHUMT00000041471
    Conserved Domains (1) summary
    pfam15365
    Location:277325
    PNRC; Proline-rich nuclear receptor coactivator

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

    Range
    89080710..89085160
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001743125.2 RNA Sequence

  2. XR_001743126.2 RNA Sequence

  3. XR_001743127.2 RNA Sequence

  4. XR_001743128.1 RNA Sequence

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