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PDIA5 protein disulfide isomerase family A member 5 [ Homo sapiens (human) ]

Gene ID: 10954, updated on 14-Jan-2021


Official Symbol
PDIA5provided by HGNC
Official Full Name
protein disulfide isomerase family A member 5provided by HGNC
Primary source
See related
Ensembl:ENSG00000065485 MIM:616942
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, three catalytically active thioredoxin (TRX) domains, a TRX-like domain, and a C-terminal ER-retention sequence. The N-terminal TRX-like domain is the primary binding site for the major ER chaperone calreticulin and possibly other proteins and substrates as well. Alternative splicing results in multiple protein- and non-protein-coding transcript variants. [provided by RefSeq, Dec 2016]
Ubiquitous expression in placenta (RPKM 25.8), prostate (RPKM 23.2) and 24 other tissues See more
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Genomic context

See PDIA5 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (123067025..123162104)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (122785856..122880953)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 49 member 4 Neighboring gene long intergenic non-protein coding RNA 2035 Neighboring gene uncharacterized LOC112268448 Neighboring gene semaphorin 5B Neighboring gene microRNA 7110 Neighboring gene SEC22 homolog A, vesicle trafficking protein Neighboring gene adenylate cyclase 5

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


GeneRIFs: Gene References Into Functions

What's a GeneRIF?


Associated conditions

Description Tests
New gene functions in megakaryopoiesis and platelet formation.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env PDI is predominantly involved in HIV-1 entry and infection of the T cell line PM-1 and PHA-stimulated primary T lymphocytes, suggesting the preferential use of PDI relevant to the HIV-1 entry and establishment of virus reservoirs in resting CD4+ cells PubMed
env The disulfide cross-linking interaction between gp120 and PDI is enhanced by CD4 protein PubMed
env HIV-1 gp120 is identified to have a physical interaction with protein disulfide isomerase family A, member 5 (PDIA5) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
env Protein-disulfide isomerase (PDI) cleaves disulfide bonds in recombinant HIV-1 envelope glycoprotein gp120, and gp120 bound to the surface receptor CD4 undergoes a disulfide reduction that is prevented by PDI inhibitors PubMed
Envelope surface glycoprotein gp160, precursor env Treatment of trimeric HIV-1 rgp140 with protein disulfide isomerase yields monomers by disruption of the intermolecular disulfide bonds PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem


Products Interactant Other Gene Complex Source Pubs Description

General gene information



Clone Names

  • FLJ30401

Gene Ontology Provided by GOA

Function Evidence Code Pubs
oxidoreductase activity TAS
Traceable Author Statement
more info
peptide disulfide oxidoreductase activity IDA
Inferred from Direct Assay
more info
protein binding IPI
Inferred from Physical Interaction
more info
protein disulfide isomerase activity TAS
Traceable Author Statement
more info
Process Evidence Code Pubs
IRE1-mediated unfolded protein response TAS
Traceable Author Statement
more info
protein folding TAS
Traceable Author Statement
more info
protein phosphopantetheinylation IEA
Inferred from Electronic Annotation
more info
Component Evidence Code Pubs
endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info

General protein information

Preferred Names
protein disulfide-isomerase A5
protein disulfide isomerase-associated 5
protein disulfide isomerase-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006810.4NP_006801.1  protein disulfide-isomerase A5 precursor

    See identical proteins and their annotated locations for NP_006801.1

    Status: VALIDATED

    Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
    Source sequence(s)
    BM549365, CA414869, D49490
    Consensus CDS
    ENSP00000323313.7, ENST00000316218.12
    Conserved Domains (3) summary
    PDI_a_PDIR; PDIa family, PDIR subfamily; composed of proteins similar to human PDIR (for Protein Disulfide Isomerase Related). PDIR is composed of three redox active TRX (a) domains and an N-terminal redox inactive TRX-like (b) domain. Similar to PDI, it is involved ...
    PDI_b_PDIR_N; PDIb family, PDIR subfamily, N-terminal TRX-like b domain; composed of proteins similar to human PDIR (for Protein Disulfide Isomerase Related). PDIR is composed of three redox active TRX (a) domains and an N-terminal redox inactive TRX-like (b) domain. ...
    PTZ00102; disulphide isomerase; Provisional


  1. NR_028444.2 RNA Sequence

    Status: VALIDATED

    Transcript Variant: This variant (2) lacks an internal exon and uses an internal alternate splice site, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC001625, BM549365

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly


  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    GenBank, FASTA, Sequence Viewer (Graphics)


  1. XR_427359.1 RNA Sequence

  2. XR_427360.1 RNA Sequence

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