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GCH1 GTP cyclohydrolase 1 [ Panthera pardus (leopard) ]

Gene ID: 109268442, updated on 14-Mar-2024

Summary

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Gene symbol
GCH1
Gene description
GTP cyclohydrolase 1
See related
Ensembl:ENSPPRG00000007288
Gene type
protein coding
RefSeq status
MODEL
Organism
Panthera pardus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Pantherinae; Panthera
Orthologs
human mouse all
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Genomic context

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See GCH1 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_02 current ASM2436296v1 (GCF_024362965.1) Unplaced Scaffold NW_026526810.1 (94372220..94420060, complement)
100 previous assembly PanPar1.0 (GCF_001857705.1) Unplaced Scaffold NW_017619866.1 (16593979..16641765)

NW_026526810.1Genomic Context describing neighboring genes Neighboring gene sterile alpha motif domain containing 4A Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC109268449 Neighboring gene uncharacterized LOC109268447 Neighboring gene WD repeat and HMG-box DNA binding protein 1 Neighboring gene U2 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables GTP cyclohydrolase I activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in tetrahydrobiopterin biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in tetrahydrofolate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
GTP cyclohydrolase 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_024362965.1-RS_2023_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM2436296v1 Primary Assembly

Genomic

  1. NW_026526810.1 Reference ASM2436296v1 Primary Assembly

    Range
    94372220..94420060 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_019451746.2 → XP_019307291.1  GTP cyclohydrolase 1 isoform X2

    UniProtKB/TrEMBL
    A0A9V1FRV8
    Conserved Domains (1) summary
    cl00263
    Location:65 → 210
    TFold; Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl ...

  2. XM_019451747.2 → XP_019307292.1  GTP cyclohydrolase 1 isoform X3

    UniProtKB/TrEMBL
    A0A9V1FQY4
    Conserved Domains (1) summary
    cd00642
    Location:65 → 208
    GTP_cyclohydro1; GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In ...

  3. XM_019451745.2 → XP_019307290.1  GTP cyclohydrolase 1 isoform X1

    UniProtKB/TrEMBL
    A0A9V1FQN4
    Related
    ENSPPRP00000014368.1
    Conserved Domains (1) summary
    cd00642
    Location:65 → 249
    GTP_cyclohydro1; GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In ...
Nucleotide Protein
Heading Accession and Version

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