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DHRS4 dehydrogenase/reductase 4 [ Homo sapiens (human) ]

Gene ID: 10901, updated on 11-Sep-2019

Summary

Official Symbol
DHRS4provided by HGNC
Official Full Name
dehydrogenase/reductase 4provided by HGNC
Primary source
HGNC:HGNC:16985
See related
Ensembl:ENSG00000157326 MIM:611596
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CR; NRDR; PHCR; PSCD; SDR-SRL; SDR25C1; SDR25C2; SCAD-SRL
Expression
Broad expression in kidney (RPKM 98.6), small intestine (RPKM 30.5) and 22 other tissues See more
Orthologs

Genomic context

See DHRS4 in Genome Data Viewer
Location:
14q11.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (23953735..23969279)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (24422944..24438488)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene dehydrogenase/reductase (SDR family) member 2 pseudogene Neighboring gene long intergenic non-protein coding RNA 596 Neighboring gene uncharacterized LOC105370411 Neighboring gene DHRS4 antisense RNA 1 Neighboring gene dehydrogenase/reductase 4 like 2 Neighboring gene dehydrogenase/reductase 4 like 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11008, FLJ54180

Gene Ontology Provided by GOA

Process Evidence Code Pubs
alcohol metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
cellular ketone metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
oxidation-reduction process IDA
Inferred from Direct Assay
more info
PubMed 
oxidation-reduction process TAS
Traceable Author Statement
more info
PubMed 
protein targeting to peroxisome TAS
Traceable Author Statement
more info
 
protein tetramerization IDA
Inferred from Direct Assay
more info
PubMed 
steroid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
peroxisomal matrix TAS
Traceable Author Statement
more info
 
peroxisomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
peroxisome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dehydrogenase/reductase SDR family member 4
Names
NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase
NADPH-dependent retinol dehydrogenase/reductase
dehydrogenase/reductase (SDR family) member 4 like 2A
peroxisomal short-chain alcohol dehydrogenase
short chain dehydrogenase/reductase family 25C member 2
short chain dehydrogenase/reductase family 25C, member 1
short-chain dehydrogenase/reductase family member 4
NP_001269916.1
NP_001269917.1
NP_001269918.1
NP_001269919.1
NP_001269920.1
NP_066284.2
XP_006720068.1
XP_011534668.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282987.2NP_001269916.1  dehydrogenase/reductase SDR family member 4 isoform 2

    See identical proteins and their annotated locations for NP_001269916.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two alternate exons in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AA293161, AY616182, CA438339
    Consensus CDS
    CCDS61408.1
    UniProtKB/Swiss-Prot
    Q9BTZ2
    Related
    ENSP00000453367.1, ENST00000558263.5
    Conserved Domains (1) summary
    cl21454
    Location:23136
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  2. NM_001282988.2NP_001269917.1  dehydrogenase/reductase SDR family member 4 isoform 3

    See identical proteins and their annotated locations for NP_001269917.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate coding exon, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AA293161, CA438339, DQ325464
    Consensus CDS
    CCDS61410.1
    UniProtKB/Swiss-Prot
    Q9BTZ2
    Related
    ENSP00000452645.1, ENST00000558581.5
    Conserved Domains (2) summary
    PRK07231
    Location:30239
    fabG; 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional
    cl21454
    Location:23244
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  3. NM_001282989.2NP_001269918.1  dehydrogenase/reductase SDR family member 4 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks three alternate exons in the 3' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AA293161, AY071856, BP366505, CA438339
    Consensus CDS
    CCDS61409.1
    UniProtKB/Swiss-Prot
    Q9BTZ2
    Related
    ENSP00000380265.3, ENST00000397075.7
    Conserved Domains (2) summary
    PRK07231
    Location:30187
    fabG; 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional
    cl21454
    Location:23192
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  4. NM_001282990.2NP_001269919.1  dehydrogenase/reductase SDR family member 4 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks two alternate coding exons, but maintains the reading frame, compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
    Source sequence(s)
    AA293161, BP366505, CA438339, DQ338571
    Consensus CDS
    CCDS61411.1
    UniProtKB/Swiss-Prot
    Q9BTZ2
    Related
    ENSP00000453983.1, ENST00000559632.5
    Conserved Domains (2) summary
    PRK07231
    Location:30194
    fabG; 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional
    cl21454
    Location:23199
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  5. NM_001282991.2NP_001269920.1  dehydrogenase/reductase SDR family member 4 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks four alternate coding exons, but maintains the reading frame, compared to variant 1. The encoded isoform (6) is shorter than isoform 1.
    Source sequence(s)
    AA293161, CA438339, CD674505
    Consensus CDS
    CCDS61412.1
    UniProtKB/Swiss-Prot
    Q9BTZ2
    Related
    ENSP00000380264.3, ENST00000397074.7
    Conserved Domains (2) summary
    PRK07231
    Location:30153
    fabG; 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional
    cl21454
    Location:23158
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  6. NM_021004.4NP_066284.2  dehydrogenase/reductase SDR family member 4 isoform 1

    See identical proteins and their annotated locations for NP_066284.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    BC003019, BQ030242, BU529016, CA438339
    Consensus CDS
    CCDS9605.1
    UniProtKB/Swiss-Prot
    Q9BTZ2
    Related
    ENSP00000326219.5, ENST00000313250.10
    Conserved Domains (2) summary
    cd08936
    Location:23278
    CR_SDR_c; Porcine peroxisomal carbonyl reductase like, classical (c) SDR
    PRK07231
    Location:30273
    fabG; 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    23953735..23969279
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006720005.3XP_006720068.1  dehydrogenase/reductase SDR family member 4 isoform X1

    Conserved Domains (2) summary
    PRK07231
    Location:30228
    fabG; 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional
    cl21454
    Location:23233
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  2. XM_011536366.2XP_011534668.1  dehydrogenase/reductase SDR family member 4 isoform X2

    See identical proteins and their annotated locations for XP_011534668.1

    Related
    ENSP00000440508.2, ENST00000543741.6
    Conserved Domains (1) summary
    cl21454
    Location:23138
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_018654722.1 Reference GRCh38.p13 PATCHES

    Range
    254749..270260
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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