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Ppp1r15b protein phosphatase 1, regulatory subunit 15B [ Mus musculus (house mouse) ]

Gene ID: 108954, updated on 8-Feb-2024

Summary

Official Symbol
Ppp1r15bprovided by MGI
Official Full Name
protein phosphatase 1, regulatory subunit 15Bprovided by MGI
Primary source
MGI:MGI:2444211
See related
Ensembl:ENSMUSG00000046062 AllianceGenome:MGI:2444211
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CReP; 1810033K10Rik; C530022L24Rik
Summary
Enables protein phosphatase regulator activity. Involved in negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation and peptidyl-serine dephosphorylation. Acts upstream of or within ER overload response and response to hydrogen peroxide. Part of protein phosphatase type 1 complex. Is expressed in compacted morula and inner cell mass. Orthologous to human PPP1R15B (protein phosphatase 1 regulatory subunit 15B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 17.3), colon adult (RPKM 16.0) and 28 other tissues See more
Orthologs
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Genomic context

See Ppp1r15b in Genome Data Viewer
Location:
1 E4; 1 57.8 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (133058904..133067538)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (133131166..133139800)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta Neighboring gene predicted gene 28609 Neighboring gene STARR-positive B cell enhancer ABC_E7750 Neighboring gene STARR-seq mESC enhancer starr_02273 Neighboring gene predicted gene, 51647 Neighboring gene STARR-seq mESC enhancer starr_02276 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:135055920-135056124 Neighboring gene pleckstrin homology domain containing, family A member 6 Neighboring gene VISTA enhancer mm971 Neighboring gene VISTA enhancer mm1460 Neighboring gene STARR-seq mESC enhancer starr_02278 Neighboring gene STARR-seq mESC enhancer starr_02279 Neighboring gene predicted gene, 51648 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:135134303-135134461 Neighboring gene predicted gene, 19461

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein phosphatase regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of protein phosphatase type 1 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of protein phosphatase type 1 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein phosphatase type 1 complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein phosphatase 1 regulatory subunit 15B
Names
constitutive repressor of eIF2alpha phosphorylation
protein phosphatase 1, regulatory (inhibitor) subunit 15b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133819.3NP_598580.1  protein phosphatase 1 regulatory subunit 15B

    See identical proteins and their annotated locations for NP_598580.1

    Status: VALIDATED

    Source sequence(s)
    AC107842, AK146089
    Consensus CDS
    CCDS15291.1
    UniProtKB/Swiss-Prot
    Q3TC78, Q8BFW3, Q8C390
    Related
    ENSMUSP00000057062.4, ENSMUST00000052529.4
    Conserved Domains (2) summary
    pfam10472
    Location:1394
    CReP_N; eIF2-alpha phosphatase phosphorylation constitutive repressor
    pfam10488
    Location:397682
    PP1c_bdg; Phosphatase-1 catalytic subunit binding region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    133058904..133067538
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)