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PPP1R15B protein phosphatase 1 regulatory subunit 15B [ Homo sapiens (human) ]

Gene ID: 84919, updated on 13-Mar-2020

Summary

Official Symbol
PPP1R15Bprovided by HGNC
Official Full Name
protein phosphatase 1 regulatory subunit 15Bprovided by HGNC
Primary source
HGNC:HGNC:14951
See related
Ensembl:ENSG00000158615 MIM:613257
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CREP; MSSGM2
Summary
This gene encodes a protein phosphatase I-interacting protein that promotes the dephosphorylation of eukaryotic translation initiation factor 2A to regulate translation under conditions of cellular stress. The transcribed messenger RNA contains two upstream open reading frames (ORFs) that repress translation of the main protein coding ORF under normal conditions, while the protein coding ORF is expressed at high levels in response to stress. Continual translation of the mRNA under conditions of eukaryotic translation initiation factor 2A inactivation is thought to create a feedback loop for reactivation of the gene during recovery from stress. In addition, it has been shown that this protein plays a role in membrane traffic that is independent of translation and that it is required for exocytosis from erythroleukemia cells. Allelic variants of this gene are associated with microcephaly, short stature, and impaired glucose metabolism. [provided by RefSeq, Feb 2016]
Expression
Ubiquitous expression in bone marrow (RPKM 43.3), gall bladder (RPKM 18.5) and 25 other tissues See more
Orthologs

Genomic context

See PPP1R15B in Genome Data Viewer
Location:
1q32.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (204398684..204412454, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (204369781..204380945, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene pleckstrin homology domain containing A6 Neighboring gene ribosomal protein L21 pseudogene 19 Neighboring gene long intergenic non-protein coding RNA 628 Neighboring gene phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta Neighboring gene VISTA enhancer hs1368 Neighboring gene tRNA-Lys (anticodon TTT) 3-1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Microcephaly, short stature, and impaired glucose metabolism 2
MedGen: C4225195 OMIM: 616817 GeneReviews: Not available
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NHGRI GWAS Catalog

Description
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14744, FLJ78991

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
ER overload response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of PERK-mediated unfolded protein response TAS
Traceable Author Statement
more info
PubMed 
negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-serine dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of phosphoprotein phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to endoplasmic reticulum stress IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to hydrogen peroxide IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphatase type 1 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphatase type 1 complex IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphatase type 1 complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
protein phosphatase 1 regulatory subunit 15B
Names
protein phosphatase 1, regulatory (inhibitor) subunit 15B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046737.1 RefSeqGene

    Range
    5001..13454
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_032833.5NP_116222.4  protein phosphatase 1 regulatory subunit 15B

    See identical proteins and their annotated locations for NP_116222.4

    Status: REVIEWED

    Source sequence(s)
    AL606489, KF459739
    Consensus CDS
    CCDS1445.1
    Related
    ENSP00000356156.4, ENST00000367188.5
    Conserved Domains (2) summary
    pfam10472
    Location:1410
    CReP_N; eIF2-alpha phosphatase phosphorylation constitutive repressor
    pfam10488
    Location:413699
    PP1c_bdg; Phosphatase-1 catalytic subunit binding region

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    204398684..204412454 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005245551.5XP_005245608.2  protein phosphatase 1 regulatory subunit 15B isoform X1

    Conserved Domains (2) summary
    pfam10472
    Location:1410
    CReP_N; eIF2-alpha phosphatase phosphorylation constitutive repressor
    pfam10488
    Location:413636
    PP1c_bdg; Phosphatase-1 catalytic subunit binding region
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