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Ston2 stonin 2 [ Mus musculus (house mouse) ]

Gene ID: 108800, updated on 5-Jan-2023

Summary

Official Symbol
Ston2provided by MGI
Official Full Name
stonin 2provided by MGI
Primary source
MGI:MGI:1918272
See related
Ensembl:ENSMUSG00000020961 AllianceGenome:MGI:1918272
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4933401N24Rik
Summary
Predicted to enable clathrin adaptor activity. Involved in regulation of endocytosis. Acts upstream of or within hematopoietic progenitor cell differentiation. Located in clathrin-coated vesicle and synaptic vesicle. Orthologous to human STON2 (stonin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 3.1), ovary adult (RPKM 2.6) and 28 other tissues See more
Orthologs
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Genomic context

See Ston2 in Genome Data Viewer
Location:
12; 12 D3
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (91599686..91753210, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (91633009..91786436, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene thyroid stimulating hormone receptor Neighboring gene predicted gene, 40541 Neighboring gene general transcription factor II A, 1 Neighboring gene predicted gene, 25776 Neighboring gene VISTA enhancer mm815 Neighboring gene ragulator complex protein LAMTOR2 pseudogene Neighboring gene predicted gene, 16876 Neighboring gene predicted gene, 34718 Neighboring gene sel-1 suppressor of lin-12-like (C. elegans) Neighboring gene signal recognition particle receptor ('docking protein') pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables clathrin adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within chemical synaptic transmission IC
Inferred by Curator
more info
PubMed 
involved_in clathrin-dependent endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within endocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within hematopoietic progenitor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in synaptic vesicle endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in synaptic vesicle endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in synaptic vesicle recycling IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of AP-2 adaptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in clathrin-coated vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynapse ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IC
Inferred by Curator
more info
PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in synaptic vesicle IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001403574.1NP_001390503.1  stonin-2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC154375, AC154709
    UniProtKB/Swiss-Prot
    A2RTJ7
  2. NM_001403575.1NP_001390504.1  stonin-2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154375, AC154709
  3. NM_175367.7NP_780576.1  stonin-2 isoform 1

    See identical proteins and their annotated locations for NP_780576.1

    Status: VALIDATED

    Source sequence(s)
    AC154375, AC154709
    Consensus CDS
    CCDS26090.1
    UniProtKB/Swiss-Prot
    A2RTJ7, Q8BZ60
    Related
    ENSMUSP00000053908.8, ENSMUST00000052969.15
    Conserved Domains (2) summary
    cd09263
    Location:556873
    AP_stonin-2_MHD; Mu homology domain (MHD) of adaptor-like protein (AP-like), stonin-2
    pfam12016
    Location:1337
    Stonin2_N; Stonin 2

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    91599686..91753210 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515374.4XP_006515437.1  stonin-2 isoform X1

    UniProtKB/Swiss-Prot
    Q8BZ60
    Conserved Domains (2) summary
    cd09263
    Location:556873
    AP_stonin-2_MHD; Mu homology domain (MHD) of adaptor-like protein (AP-like), stonin-2
    pfam12016
    Location:1337
    Stonin2_N; Stonin 2
  2. XM_006515373.5XP_006515436.1  stonin-2 isoform X1

    See identical proteins and their annotated locations for XP_006515436.1

    UniProtKB/Swiss-Prot
    A2RTJ7, Q8BZ60
    Conserved Domains (2) summary
    cd09263
    Location:556873
    AP_stonin-2_MHD; Mu homology domain (MHD) of adaptor-like protein (AP-like), stonin-2
    pfam12016
    Location:1337
    Stonin2_N; Stonin 2
  3. XM_011243982.3XP_011242284.1  stonin-2 isoform X1

    See identical proteins and their annotated locations for XP_011242284.1

    UniProtKB/Swiss-Prot
    A2RTJ7, Q8BZ60
    Related
    ENSMUSP00000131098.2, ENSMUST00000164713.8
    Conserved Domains (2) summary
    cd09263
    Location:556873
    AP_stonin-2_MHD; Mu homology domain (MHD) of adaptor-like protein (AP-like), stonin-2
    pfam12016
    Location:1337
    Stonin2_N; Stonin 2
  4. XM_006515379.5XP_006515442.1  stonin-2 isoform X3

    See identical proteins and their annotated locations for XP_006515442.1

    Conserved Domains (2) summary
    cd09263
    Location:430747
    AP_stonin-2_MHD; Mu homology domain (MHD) of adaptor-like protein (AP-like), stonin-2
    pfam12016
    Location:1211
    Stonin2_N; Stonin 2
  5. XM_006515380.4XP_006515443.1  stonin-2 isoform X3

    See identical proteins and their annotated locations for XP_006515443.1

    Conserved Domains (2) summary
    cd09263
    Location:430747
    AP_stonin-2_MHD; Mu homology domain (MHD) of adaptor-like protein (AP-like), stonin-2
    pfam12016
    Location:1211
    Stonin2_N; Stonin 2
  6. XM_006515378.5XP_006515441.1  stonin-2 isoform X3

    See identical proteins and their annotated locations for XP_006515441.1

    Conserved Domains (2) summary
    cd09263
    Location:430747
    AP_stonin-2_MHD; Mu homology domain (MHD) of adaptor-like protein (AP-like), stonin-2
    pfam12016
    Location:1211
    Stonin2_N; Stonin 2
  7. XM_006515375.5XP_006515438.1  stonin-2 isoform X2

    Conserved Domains (2) summary
    cd09263
    Location:437754
    AP_stonin-2_MHD; Mu homology domain (MHD) of adaptor-like protein (AP-like), stonin-2
    pfam12016
    Location:3218
    Stonin2_N; Stonin 2
  8. XM_006515376.5XP_006515439.1  stonin-2 isoform X3

    See identical proteins and their annotated locations for XP_006515439.1

    Conserved Domains (2) summary
    cd09263
    Location:430747
    AP_stonin-2_MHD; Mu homology domain (MHD) of adaptor-like protein (AP-like), stonin-2
    pfam12016
    Location:1211
    Stonin2_N; Stonin 2
  9. XM_011243985.4XP_011242287.1  stonin-2 isoform X4

    See identical proteins and their annotated locations for XP_011242287.1

    Conserved Domains (2) summary
    cd09263
    Location:356673
    AP_stonin-2_MHD; Mu homology domain (MHD) of adaptor-like protein (AP-like), stonin-2
    pfam12016
    Location:1137
    Stonin2_N; Stonin 2
  10. XM_036157157.1XP_036013050.1  stonin-2 isoform X3

    Conserved Domains (2) summary
    cd09263
    Location:430747
    AP_stonin-2_MHD; Mu homology domain (MHD) of adaptor-like protein (AP-like), stonin-2
    pfam12016
    Location:1211
    Stonin2_N; Stonin 2
  11. XM_006515381.4XP_006515444.1  stonin-2 isoform X4

    Conserved Domains (2) summary
    cd09263
    Location:356673
    AP_stonin-2_MHD; Mu homology domain (MHD) of adaptor-like protein (AP-like), stonin-2
    pfam12016
    Location:1137
    Stonin2_N; Stonin 2