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FGL2 fibrinogen like 2 [ Homo sapiens (human) ]

Gene ID: 10875, updated on 21-Dec-2019

Summary

Official Symbol
FGL2provided by HGNC
Official Full Name
fibrinogen like 2provided by HGNC
Primary source
HGNC:HGNC:3696
See related
Ensembl:ENSG00000127951 MIM:605351
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
T49; pT49
Summary
The protein encoded by this gene is a secreted protein that is similar to the beta- and gamma-chains of fibrinogen. The carboxyl-terminus of the encoded protein consists of the fibrinogen-related domains (FRED). The encoded protein forms a tetrameric complex which is stabilized by interchain disulfide bonds. This protein may play a role in physiologic functions at mucosal sites. [provided by RefSeq, Jul 2008]
Expression
Broad expression in spleen (RPKM 83.3), appendix (RPKM 61.0) and 22 other tissues See more
Orthologs

Genomic context

See FGL2 in Genome Data Viewer
Location:
7q11.23
Exon count:
2
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (77193369..77199819, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (76822688..76829150, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 pseudogene Neighboring gene family with sequence similarity 185, member A pseudogene Neighboring gene ribosomal protein L7a pseudogene 43 Neighboring gene coiled-coil domain containing 146 Neighboring gene uncharacterized LOC105375359 Neighboring gene uncharacterized LOC102723791

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of fibrinogen-like 2 (FGL2) in peptide-treated PBMCs PubMed
Tat tat HIV-1 Tat downregulates the expression of fibrinogen-like 2 (FGL2) in human primary T cells PubMed
Vif vif HIV-1 Vif downregulates the expression of fibrinogen-like 2 (FGL2) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

General protein information

Preferred Names
fibroleukin
Names
fibrinogen-like protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006682.3NP_006673.1  fibroleukin precursor

    See identical proteins and their annotated locations for NP_006673.1

    Status: REVIEWED

    Source sequence(s)
    AC007000, BC033820
    Consensus CDS
    CCDS5591.1
    UniProtKB/Swiss-Prot
    Q14314
    UniProtKB/TrEMBL
    A4D1B8
    Related
    ENSP00000248598.5, ENST00000248598.6
    Conserved Domains (2) summary
    cl00085
    Location:209435
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
    cl27170
    Location:28161
    DUF460; Protein of unknown function (DUF460)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    77193369..77199819 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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