Format

Send to:

Choose Destination

NMU neuromedin U [ Homo sapiens (human) ]

Gene ID: 10874, updated on 1-Aug-2020

Summary

Official Symbol
NMUprovided by HGNC
Official Full Name
neuromedin Uprovided by HGNC
Primary source
HGNC:HGNC:7859
See related
Ensembl:ENSG00000109255 MIM:605103
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the neuromedin family of neuropeptides. The encoded protein is a precursor that is proteolytically processed to generate a biologically active neuropeptide that plays a role in pain, stress, immune-mediated inflammatory diseases and feeding regulation. Increased expression of this gene was observed in renal, pancreatic and lung cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. Some of these isoforms may undergo similar processing to generate the mature peptide. [provided by RefSeq, Jul 2015]
Expression
Biased expression in esophagus (RPKM 5.6), skin (RPKM 5.5) and 6 other tissues See more
Orthologs

Genomic context

See NMU in Genome Data Viewer
Location:
4q12
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (55595231..55636793, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (56461396..56502465, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene clock circadian regulator Neighboring gene RN7SK pseudogene 30 Neighboring gene phosducin like 2 Neighboring gene uncharacterized LOC105377660 Neighboring gene CRISPRi-validated cis-regulatory element chr4.1623

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
neuromedin U receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor binding TAS
Traceable Author Statement
more info
PubMed 
type 1 neuromedin U receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
type 2 neuromedin U receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
eating behavior IEA
Inferred from Electronic Annotation
more info
 
energy homeostasis IEA
Inferred from Electronic Annotation
more info
 
gastric acid secretion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of eating behavior IEA
Inferred from Electronic Annotation
more info
 
negative regulation of gastric acid secretion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of gastric emptying IEA
Inferred from Electronic Annotation
more info
 
neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuropeptide signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
photoperiodism IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of heart rate IEA
Inferred from Electronic Annotation
more info
 
positive regulation of heat generation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of prolactin secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
positive regulation of smooth muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of stomach fundus smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
 
positive regulation of synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of systemic arterial blood pressure IEA
Inferred from Electronic Annotation
more info
 
regulation of circadian sleep/wake cycle, sleep IEA
Inferred from Electronic Annotation
more info
 
regulation of grooming behavior IEA
Inferred from Electronic Annotation
more info
 
sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
temperature homeostasis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
 
terminal bouton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
neuromedin-U
Names
neuromedin U precursor-related peptide/neuromedin U preproprotein
prepro-NMU

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001292045.2NP_001278974.1  neuromedin-U isoform 2 precursor

    See identical proteins and their annotated locations for NP_001278974.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 2, which lacks an internal segment and is shorter than isoform 1. This isoform (2) may undergo processing similar to isoform 1 to generate mature peptide.
    Source sequence(s)
    BC012908, BI603117, BQ049320
    Consensus CDS
    CCDS75125.1
    UniProtKB/Swiss-Prot
    P48645
    UniProtKB/TrEMBL
    A0A0B4J202
    Related
    ENSP00000422399.1, ENST00000511469.5
    Conserved Domains (1) summary
    smart00084
    Location:126150
    NMU; Neuromedin U
  2. NM_001292046.2NP_001278975.1  neuromedin-U isoform 3 precursor

    See identical proteins and their annotated locations for NP_001278975.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform 3, which lacks an internal segment and is shorter than isoform 1.
    Source sequence(s)
    AJ510133, BC012908, BF185217, BI603117, BQ049320
    Consensus CDS
    CCDS77914.1
    UniProtKB/Swiss-Prot
    P48645
    UniProtKB/TrEMBL
    E9PDJ7, Q86WB6
    Related
    ENSP00000422870.1, ENST00000507338.1
    Conserved Domains (1) summary
    smart00084
    Location:119141
    NMU; Neuromedin U
  3. NM_006681.4NP_006672.1  neuromedin-U isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_006672.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    BC012908, BI603117, X76029
    Consensus CDS
    CCDS3501.1
    UniProtKB/Swiss-Prot
    P48645
    UniProtKB/TrEMBL
    A0A250SH36
    Related
    ENSP00000264218.3, ENST00000264218.7
    Conserved Domains (1) summary
    smart00084
    Location:142166
    NMU; Neuromedin U

RNA

  1. NR_120489.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternate 5' terminal exon and lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AC024243, BC012908, CN343322

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    55595231..55636793 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534368.3XP_011532670.1  neuromedin-U isoform X2

    See identical proteins and their annotated locations for XP_011532670.1

    Conserved Domains (1) summary
    smart00084
    Location:108132
    NMU; Neuromedin U
  2. XM_011534367.2XP_011532669.1  neuromedin-U isoform X1

    Conserved Domains (1) summary
    smart00084
    Location:125149
    NMU; Neuromedin U
Support Center