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Nmu neuromedin U [ Mus musculus (house mouse) ]

Gene ID: 56183, updated on 8-Nov-2022

Summary

Official Symbol
Nmuprovided by MGI
Official Full Name
neuromedin Uprovided by MGI
Primary source
MGI:MGI:1860476
See related
Ensembl:ENSMUSG00000029236 AllianceGenome:MGI:1860476
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable type 1 neuromedin U receptor binding activity and type 2 neuromedin U receptor binding activity. Involved in several processes, including energy homeostasis; regulation of grooming behavior; and temperature homeostasis. Predicted to be located in extracellular region. Predicted to be active in terminal bouton. Is expressed in spinal cord; stomach; and testis. Human ortholog(s) of this gene implicated in obesity. Orthologous to human NMU (neuromedin U). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in stomach adult (RPKM 10.4), colon adult (RPKM 3.1) and 3 other tissues See more
Orthologs
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Genomic context

See Nmu in Genome Data Viewer
Location:
5; 5 C3.3
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (76481342..76511624, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (76333495..76363777, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene 7467 Neighboring gene RIKEN cDNA 4930432L08 gene Neighboring gene phosducin-like 2 Neighboring gene predicted gene, 34175 Neighboring gene exocyst complex component 1 like Neighboring gene exocyst complex component 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables neuromedin U receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables neuromedin U receptor binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables type 1 neuromedin U receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables type 2 neuromedin U receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in eating behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in energy homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in energy homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in gastric acid secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of eating behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of feeding behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gastric acid secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gastric emptying ISO
Inferred from Sequence Orthology
more info
 
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within neuropeptide signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in neuropeptide signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of heart rate ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of heat generation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of hormone secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of prolactin secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of stomach fundus smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of systemic arterial blood pressure ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of circadian sleep/wake cycle, sleep ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of feeding behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of grooming behavior IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of grooming behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
 
involved_in sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
involved_in temperature homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in terminal bouton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in terminal bouton ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
neuromedin-U
Names
neuromedin U precursor-related peptide/neuromedin U preproprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019515.1NP_062388.1  neuromedin-U precursor

    See identical proteins and their annotated locations for NP_062388.1

    Status: PROVISIONAL

    Source sequence(s)
    AF203444
    Consensus CDS
    CCDS19362.1
    UniProtKB/Swiss-Prot
    Q9QXK8
    UniProtKB/TrEMBL
    A0A8C6HMP2, Q059S5
    Related
    ENSMUSP00000031146.3, ENSMUST00000031146.3
    Conserved Domains (1) summary
    pfam02070
    Location:144166
    NMU; Neuromedin U

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    76481342..76511624 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)