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Ccdc88a coiled coil domain containing 88A [ Mus musculus (house mouse) ]

Gene ID: 108686, updated on 21-Apr-2024

Summary

Official Symbol
Ccdc88aprovided by MGI
Official Full Name
coiled coil domain containing 88Aprovided by MGI
Primary source
MGI:MGI:1925177
See related
Ensembl:ENSMUSG00000032740 AllianceGenome:MGI:1925177
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ape; Giv; Grdn; Hkrp1; Girdin; A430106J12Rik; C130096N06Rik; C330012F17Rik; D130005J21Rik
Summary
Enables microtubule binding activity and protein kinase B binding activity. Involved in several processes, including TOR signaling; activation of protein kinase B activity; and regulation of DNA replication. Located in cell leading edge. Is expressed in several structures, including limb; lung; nervous system; sensory organ; and somite. Orthologous to human CCDC88A (coiled-coil domain containing 88A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 8.1), whole brain E14.5 (RPKM 7.1) and 18 other tissues See more
Orthologs
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Genomic context

Location:
11 A3.3; 11 16.61 cM
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (29323521..29460808)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (29373405..29510808)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 23109 Neighboring gene predicted gene 12087 Neighboring gene predicted gene, 51886 Neighboring gene STARR-seq mESC enhancer starr_29023 Neighboring gene STARR-positive B cell enhancer ABC_E3936 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:29426294-29426403 Neighboring gene prolyl-tRNA synthetase domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_29024 Neighboring gene mitochondrial translational initiation factor 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G-protein alpha-subunit binding ISO
Inferred from Sequence Orthology
more info
 
enables G-protein gamma-subunit binding ISO
Inferred from Sequence Orthology
more info
 
enables GDP-dissociation inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables SH2 domain binding ISO
Inferred from Sequence Orthology
more info
 
enables actin binding ISO
Inferred from Sequence Orthology
more info
 
enables dynein light intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables epidermal growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
enables insulin receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylinositol binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase B binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase B binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase C binding ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables vascular endothelial growth factor receptor 2 binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in TOR signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in activation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell projection organization IEA
Inferred from Electronic Annotation
more info
 
involved_in cytoplasmic microtubule organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cytoskeleton-dependent intracellular transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in lamellipodium assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in maintenance of protein location in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in membrane organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cilium assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein localization to cilium ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of neuron projection development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in small GTPase-mediated signal transduction ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in COPI-coated Golgi to ER transport vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in cell leading edge IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in centriole ISO
Inferred from Sequence Orthology
more info
 
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
girdin
Names
Akt-phosphorylation enhancer
Hook-related protein 1
coiled-coil domain-containing protein 88A
g alpha-interacting vesicle-associated protein
girders of actin filament

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363368.1NP_001350297.1  girdin isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL935054, BX284634
    UniProtKB/TrEMBL
    A0A6I8MX08
    Related
    ENSMUSP00000159356.2, ENSMUST00000239407.2
    Conserved Domains (1) summary
    cl25732
    Location:4771331
    SMC_N; RecF/RecN/SMC N terminal domain
  2. NM_001363369.1NP_001350298.1  girdin isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL935054, BX284634
    Conserved Domains (1) summary
    cl25732
    Location:4771331
    SMC_N; RecF/RecN/SMC N terminal domain
  3. NM_176841.5NP_789811.2  girdin isoform 3

    See identical proteins and their annotated locations for NP_789811.2

    Status: VALIDATED

    Source sequence(s)
    AI530462, AK082029, AL935054, BX284634, CD803848, CN458498, CN532842, CO044538
    Consensus CDS
    CCDS24494.1
    UniProtKB/Swiss-Prot
    Q5SNZ0
    Related
    ENSMUSP00000048978.7, ENSMUST00000040182.13
    Conserved Domains (6) summary
    TIGR04523
    Location:4931205
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    pfam05622
    Location:18584
    HOOK; HOOK protein
    pfam06156
    Location:10611107
    DUF972; Protein of unknown function (DUF972)
    pfam09455
    Location:488638
    Cas_DxTHG; CRISPR-associated (Cas) DxTHG family
    cl09111
    Location:766859
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
    cl19252
    Location:825943
    MreC; rod shape-determining protein MreC

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    29323521..29460808
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514455.5XP_006514518.1  girdin isoform X6

    See identical proteins and their annotated locations for XP_006514518.1

    UniProtKB/Swiss-Prot
    Q5M6X2, Q5M6X4, Q5M6X5, Q5SNZ0, Q5SNZ1, Q8C486, Q8CFU7
    Conserved Domains (2) summary
    COG1196
    Location:4771331
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam05622
    Location:18586
    HOOK; HOOK protein
  2. XM_036156225.1XP_036012118.1  girdin isoform X7

    Conserved Domains (2) summary
    COG1196
    Location:4771331
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd22229
    Location:10165
    HkD_Girdin; Hook domain found in Girdin and similar proteins
  3. XM_030245467.2XP_030101327.1  girdin isoform X8

    Conserved Domains (2) summary
    COG1196
    Location:4771331
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam05622
    Location:18586
    HOOK; HOOK protein
  4. XM_036156226.1XP_036012119.1  girdin isoform X9

    Conserved Domains (2) summary
    COG1196
    Location:4771308
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd22229
    Location:10165
    HkD_Girdin; Hook domain found in Girdin and similar proteins
  5. XM_017314219.3XP_017169708.1  girdin isoform X10

    Conserved Domains (2) summary
    COG1196
    Location:4771308
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam05622
    Location:18586
    HOOK; HOOK protein
  6. XM_006514452.5XP_006514515.1  girdin isoform X3

    Conserved Domains (2) summary
    COG1196
    Location:4771331
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam05622
    Location:18586
    HOOK; HOOK protein
  7. XM_036156223.1XP_036012116.1  girdin isoform X1

    Conserved Domains (2) summary
    COG1196
    Location:4771331
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd22229
    Location:10165
    HkD_Girdin; Hook domain found in Girdin and similar proteins
  8. XM_006514451.5XP_006514514.1  girdin isoform X2

    Conserved Domains (2) summary
    COG1196
    Location:4771331
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam05622
    Location:18586
    HOOK; HOOK protein
  9. XM_036156224.1XP_036012117.1  girdin isoform X4

    Conserved Domains (2) summary
    COG1196
    Location:4771331
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd22229
    Location:10165
    HkD_Girdin; Hook domain found in Girdin and similar proteins
  10. XM_006514454.5XP_006514517.1  girdin isoform X5

    Conserved Domains (2) summary
    COG1196
    Location:4771331
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam05622
    Location:18586
    HOOK; HOOK protein
  11. XM_036156227.1XP_036012120.1  girdin isoform X11

    Conserved Domains (3) summary
    COG1196
    Location:4911232
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15921
    Location:182676
    CCDC158; Coiled-coil domain-containing protein 158
    cd22229
    Location:10165
    HkD_Girdin; Hook domain found in Girdin and similar proteins