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SLC26A1 solute carrier family 26 member 1 [ Homo sapiens (human) ]

Gene ID: 10861, updated on 13-Mar-2020

Summary

Official Symbol
SLC26A1provided by HGNC
Official Full Name
solute carrier family 26 member 1provided by HGNC
Primary source
HGNC:HGNC:10993
See related
Ensembl:ENSG00000145217 MIM:610130
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAON; EDM4; SAT1; SAT-1
Summary
This gene is a member of a family of sulfate/anion transporter genes. Family members are well conserved in their genomic (number and size of exons) and protein (aa length among species) structures, but have markedly different tissue expression patterns. This gene is primarily expressed in the liver, pancreas, and brain. Three splice variants that encode different isoforms have been identified. [provided by RefSeq, Jul 2008]
Expression
Broad expression in kidney (RPKM 6.4), liver (RPKM 1.9) and 19 other tissues See more
Orthologs

Genomic context

See SLC26A1 in Genome Data Viewer
Location:
4p16.3
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (979073..993404, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (972861..987228, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene transmembrane protein 175 Neighboring gene diacylglycerol kinase theta Neighboring gene alpha-L-iduronidase Neighboring gene fibroblast growth factor receptor like 1 Neighboring gene uncharacterized LOC105374343

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
anion:anion antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
anion:anion antiporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
bicarbonate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chloride transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chloride transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
oxalate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxalate transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
secondary active sulfate transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
sulfate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sulfate transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
3'-phosphoadenosine 5'-phosphosulfate biosynthetic process TAS
Traceable Author Statement
more info
 
bicarbonate transport IEA
Inferred from Electronic Annotation
more info
 
chloride transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
chloride transport ISS
Inferred from Sequence or Structural Similarity
more info
 
ion transport TAS
Traceable Author Statement
more info
 
oxalate transport ISS
Inferred from Sequence or Structural Similarity
more info
 
sulfate transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
sulfate transport ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
sulfate anion transporter 1
Names
solute carrier family 26 (anion exchanger), member 1
solute carrier family 26 (sulfate transporter), member 1
sulfate anion tranporter AT1
sulfate/anion transporter SAT-1 protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033042.1 RefSeqGene

    Range
    5033..19364
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_022042.4NP_071325.2  sulfate anion transporter 1 isoform a

    See identical proteins and their annotated locations for NP_071325.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks an exon in the 5' UTR, as compared to variant 3. Both variants 1 and 3 encode the same isoform (a).
    Source sequence(s)
    AK292747, AY124771
    Consensus CDS
    CCDS33934.1
    UniProtKB/Swiss-Prot
    Q9H2B4
    Related
    ENSP00000381528.2, ENST00000398516.3
    Conserved Domains (2) summary
    cd07042
    Location:528669
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    TIGR00815
    Location:55683
    sulP; high affinity sulphate transporter 1
  2. NM_134425.3NP_602297.1  sulfate anion transporter 1 isoform b

    See identical proteins and their annotated locations for NP_602297.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' UTR and has an alternate 3' terminal exon, as compared to variant 3. It encodes isoform b which has a shorter and different C-terminus compared to isoform a.
    Source sequence(s)
    AK292747, BC015517
    Consensus CDS
    CCDS33933.1
    UniProtKB/Swiss-Prot
    Q9H2B4
    Related
    ENSP00000381532.2, ENST00000398520.6
    Conserved Domains (1) summary
    cl28030
    Location:55196
    Sulfate_transp; Sulfate permease family
  3. NM_213613.4NP_998778.1  sulfate anion transporter 1 isoform a

    See identical proteins and their annotated locations for NP_998778.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AY124771
    Consensus CDS
    CCDS33934.1
    UniProtKB/Swiss-Prot
    Q9H2B4
    Related
    ENSP00000354721.2, ENST00000361661.6
    Conserved Domains (2) summary
    cd07042
    Location:528669
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    TIGR00815
    Location:55683
    sulP; high affinity sulphate transporter 1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    979073..993404 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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