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Slc26a1 solute carrier family 26 (sulfate transporter), member 1 [ Mus musculus (house mouse) ]

Gene ID: 231583, updated on 8-Feb-2025

Summary

Official Symbol
Slc26a1provided by MGI
Official Full Name
solute carrier family 26 (sulfate transporter), member 1provided by MGI
Primary source
MGI:MGI:2385894
See related
Ensembl:ENSMUSG00000046959 AllianceGenome:MGI:2385894
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sat1
Summary
Enables chloride transmembrane transporter activity; oxalate transmembrane transporter activity; and sulfate:bicarbonate antiporter activity. Involved in chloride transport; oxalate transport; and sulfate transmembrane transport. Located in basolateral plasma membrane. Is expressed in several structures, including alimentary system; integumental system; liver; nose; and urinary system. Human ortholog(s) of this gene implicated in calcium oxalate nephrolithiasis. Orthologous to human SLC26A1 (solute carrier family 26 member 1). [provided by Alliance of Genome Resources, Feb 2025]
Expression
Biased expression in liver adult (RPKM 59.7), kidney adult (RPKM 58.5) and 4 other tissues See more
Orthologs
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Genomic context

See Slc26a1 in Genome Data Viewer
Location:
5 F; 5 53.24 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (108817744..108826246, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (108669878..108678380, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene cyclin G associated kinase Neighboring gene transmembrane protein 175 Neighboring gene diacylglycerol kinase, theta Neighboring gene iduronidase, alpha-L Neighboring gene predicted gene, 42151 Neighboring gene fibroblast growth factor receptor-like 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in bicarbonate transport IEA
Inferred from Electronic Annotation
more info
 
involved_in chloride transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in chloride transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within chloride transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in chloride transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within oxalate transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in oxalate transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in sulfate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within sulfate transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in sulfate transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in sulfate transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
sulfate anion transporter 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310691.1NP_001297620.1  sulfate anion transporter 1 isoform 1

    See identical proteins and their annotated locations for NP_001297620.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC161813
    Consensus CDS
    CCDS80355.1
    UniProtKB/TrEMBL
    G5E8U1, Q8R4W9
    Related
    ENSMUSP00000113185.2, ENSMUST00000119270.2
    Conserved Domains (2) summary
    cd07042
    Location:554686
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    TIGR00815
    Location:71702
    sulP; high affinity sulphate transporter 1
  2. NM_001310692.1NP_001297621.1  sulfate anion transporter 1 isoform 2

    See identical proteins and their annotated locations for NP_001297621.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks a segment in the 5' UTR and 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1. Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AC161813
    Consensus CDS
    CCDS19517.1
    UniProtKB/Swiss-Prot
    P58735, Q80WF6
    UniProtKB/TrEMBL
    Q3UPH6, Q8R4W9
    Related
    ENSMUSP00000131282.2, ENSMUST00000163328.8
    Conserved Domains (1) summary
    TIGR00815
    Location:55686
    sulP; high affinity sulphate transporter 1
  3. NM_174870.4NP_777359.3  sulfate anion transporter 1 isoform 2

    See identical proteins and their annotated locations for NP_777359.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1. Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AC161813, AK143528
    Consensus CDS
    CCDS19517.1
    UniProtKB/Swiss-Prot
    P58735, Q80WF6
    UniProtKB/TrEMBL
    Q3UPH6, Q8R4W9
    Related
    ENSMUSP00000051561.8, ENSMUST00000051757.14
    Conserved Domains (1) summary
    TIGR00815
    Location:55686
    sulP; high affinity sulphate transporter 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    108817744..108826246 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254412.1XP_030110272.1  sulfate anion transporter 1 isoform X1

    UniProtKB/Swiss-Prot
    P58735, Q80WF6
    UniProtKB/TrEMBL
    Q3UPH6, Q8R4W9
    Conserved Domains (1) summary
    TIGR00815
    Location:55686
    sulP; high affinity sulphate transporter 1
  2. XM_017320856.2XP_017176345.1  sulfate anion transporter 1 isoform X1

    UniProtKB/Swiss-Prot
    P58735, Q80WF6
    UniProtKB/TrEMBL
    Q3UPH6, Q8R4W9
    Conserved Domains (1) summary
    TIGR00815
    Location:55686
    sulP; high affinity sulphate transporter 1
  3. XM_036165081.1XP_036020974.1  sulfate anion transporter 1 isoform X1

    UniProtKB/Swiss-Prot
    P58735, Q80WF6
    UniProtKB/TrEMBL
    Q3UPH6, Q8R4W9
    Conserved Domains (1) summary
    TIGR00815
    Location:55686
    sulP; high affinity sulphate transporter 1
  4. XM_030254414.1XP_030110274.1  sulfate anion transporter 1 isoform X1

    UniProtKB/Swiss-Prot
    P58735, Q80WF6
    UniProtKB/TrEMBL
    Q3UPH6, Q8R4W9
    Conserved Domains (1) summary
    TIGR00815
    Location:55686
    sulP; high affinity sulphate transporter 1
  5. XM_030254411.1XP_030110271.1  sulfate anion transporter 1 isoform X1

    UniProtKB/Swiss-Prot
    P58735, Q80WF6
    UniProtKB/TrEMBL
    Q3UPH6, Q8R4W9
    Conserved Domains (1) summary
    TIGR00815
    Location:55686
    sulP; high affinity sulphate transporter 1
  6. XM_017320855.2XP_017176344.1  sulfate anion transporter 1 isoform X1

    UniProtKB/Swiss-Prot
    P58735, Q80WF6
    UniProtKB/TrEMBL
    Q3UPH6, Q8R4W9
    Conserved Domains (1) summary
    TIGR00815
    Location:55686
    sulP; high affinity sulphate transporter 1
  7. XM_030254413.2XP_030110273.1  sulfate anion transporter 1 isoform X1

    UniProtKB/Swiss-Prot
    P58735, Q80WF6
    UniProtKB/TrEMBL
    Q3UPH6, Q8R4W9
    Conserved Domains (1) summary
    TIGR00815
    Location:55686
    sulP; high affinity sulphate transporter 1
  8. XM_036165082.1XP_036020975.1  sulfate anion transporter 1 isoform X1

    UniProtKB/Swiss-Prot
    P58735, Q80WF6
    UniProtKB/TrEMBL
    Q3UPH6, Q8R4W9
    Conserved Domains (1) summary
    TIGR00815
    Location:55686
    sulP; high affinity sulphate transporter 1