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FRS3 fibroblast growth factor receptor substrate 3 [ Homo sapiens (human) ]

Gene ID: 10817, updated on 1-Jun-2020

Summary

Official Symbol
FRS3provided by HGNC
Official Full Name
fibroblast growth factor receptor substrate 3provided by HGNC
Primary source
HGNC:HGNC:16970
See related
Ensembl:ENSG00000137218 MIM:607744
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SNT2; FRS2B; SNT-2; FRS2beta; FRS2-beta
Summary
This gene encodes a substrate for the fibroblast growth factor receptor. The encoded protein is found in the peripheral plasma membrane and links fibroblast growth factor receptor stimulation to activators of Ras. The encoded protein down-regulates extracellular regulated kinase 2 through direct binding. [provided by RefSeq, Jul 2013]
Expression
Broad expression in testis (RPKM 6.0), brain (RPKM 2.3) and 23 other tissues See more
Orthologs

Genomic context

See FRS3 in Genome Data Viewer
Location:
6p21.1
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (41770176..41779900, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (41737914..41747643, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene transcription factor EB Neighboring gene microRNA 10398 Neighboring gene progastricsin Neighboring gene prickle planar cell polarity protein 4 Neighboring gene translocase of outer mitochondrial membrane 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC17167

Gene Ontology Provided by GOA

Function Evidence Code Pubs
fibroblast growth factor receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
MAPK cascade TAS
Traceable Author Statement
more info
 
fibroblast growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
fibroblast growth factor receptor substrate 3
Names
FGFR substrate 3
FGFR-signaling adaptor SNT2
suc1-associated neurotrophic factor target 2 (FGFR signalling adaptor)
testicular tissue protein Li 71

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006653.5NP_006644.1  fibroblast growth factor receptor substrate 3

    See identical proteins and their annotated locations for NP_006644.1

    Status: REVIEWED

    Source sequence(s)
    AF036718, HY036161
    Consensus CDS
    CCDS4860.1
    UniProtKB/Swiss-Prot
    O43559
    UniProtKB/TrEMBL
    A0A140VJJ7
    Related
    ENSP00000362109.3, ENST00000373018.7
    Conserved Domains (1) summary
    cd01202
    Location:15106
    PTB_FRS2; Fibroblast growth factor receptor substrate 2 phosphotyrosine-binding domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    41770176..41779900 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514255.2XP_011512557.1  fibroblast growth factor receptor substrate 3 isoform X1

    See identical proteins and their annotated locations for XP_011512557.1

    UniProtKB/Swiss-Prot
    O43559
    UniProtKB/TrEMBL
    A0A140VJJ7
    Conserved Domains (1) summary
    cd01202
    Location:15106
    PTB_FRS2; Fibroblast growth factor receptor substrate 2 phosphotyrosine-binding domain
  2. XM_011514254.2XP_011512556.1  fibroblast growth factor receptor substrate 3 isoform X1

    See identical proteins and their annotated locations for XP_011512556.1

    UniProtKB/Swiss-Prot
    O43559
    UniProtKB/TrEMBL
    A0A140VJJ7
    Conserved Domains (1) summary
    cd01202
    Location:15106
    PTB_FRS2; Fibroblast growth factor receptor substrate 2 phosphotyrosine-binding domain
  3. XM_017010193.1XP_016865682.1  fibroblast growth factor receptor substrate 3 isoform X2

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