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Frs3 fibroblast growth factor receptor substrate 3 [ Mus musculus (house mouse) ]

Gene ID: 107971, updated on 12-May-2024

Summary

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Official Symbol
Frs3provided by MGI
Official Full Name
fibroblast growth factor receptor substrate 3provided by MGI
Primary source
MGI:MGI:2135965
See related
Ensembl:ENSMUSG00000023266 AllianceGenome:MGI:2135965
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Snt2; Frs2beta; 4930417B13Rik
Summary
Predicted to enable fibroblast growth factor receptor binding activity; identical protein binding activity; and transmembrane receptor protein tyrosine kinase adaptor activity. Predicted to be involved in fibroblast growth factor receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; gut; immune system; lung; and metanephros. Orthologous to human FRS3 (fibroblast growth factor receptor substrate 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 16.9), CNS E18 (RPKM 9.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Frs3 in Genome Data Viewer
Location:
17 C; 17 23.88 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (47998532..48015211)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (47687607..47704286)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene 20517 Neighboring gene mediator complex subunit 20 Neighboring gene Kpna2 retrotransposed pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10959 Neighboring gene ubiquitin specific peptidase 49 Neighboring gene STARR-positive B cell enhancer ABC_E4218 Neighboring gene prickle planar cell polarity protein 4 Neighboring gene translocase of outer mitochondrial membrane 6, opposite strand Neighboring gene translocase of outer mitochondrial membrane 6 Neighboring gene STARR-seq mESC enhancer starr_42721 Neighboring gene fibroblast growth factor receptor substrate 3, opposite strand Neighboring gene STARR-seq mESC enhancer starr_42724 Neighboring gene predicted gene, 46579 Neighboring gene progastricsin (pepsinogen C)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The membrane-linked adaptor FRS2β fashions a cytokine-rich inflammatory microenvironment that promotes breast cancer carcinogenesis. Takeuchi Y, et al. Proc Natl Acad Sci U S A, 2021 Oct 26. PMID 34663724, Free PMC Article
  2. Neurotrophin and FGF Signaling Adapter Proteins, FRS2 and FRS3, Regulate Dentate Granule Cell Maturation and Excitatory Synaptogenesis. Nandi S, et al. Neuroscience, 2018 Jan 15. PMID 29155277, Free PMC Article
  3. Identification of multiple SNT-binding sites on NPM-ALK oncoprotein and their involvement in cell transformation. Chikamori M, et al. Oncogene, 2007 May 3. PMID 17086210
  4. Genomic organization and comparative sequence analysis of the mouse and human FRS2, FRS3 genes. Zhou L, et al. Mol Biol Rep, 2003 Mar. PMID 12688531
  5. Prominent expression of FRS2beta protein in neural cells and its association with intracellular vesicles. Minegishi Y, et al. FEBS Lett, 2009 Feb 18. PMID 19187780

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The membrane-linked adaptor FRS2beta fashions a cytokine-rich inflammatory microenvironment that promotes breast cancer carcinogenesis.
    Title: The membrane-linked adaptor FRS2β fashions a cytokine-rich inflammatory microenvironment that promotes breast cancer carcinogenesis.
  2. FRS2 and FRS3, are together required for postnatal brain development. In the hippocampus, FRS2&3 promote dentate gyrus morphogenesis and dentate granule cell (DGC) maturation during developmental neurogenesis. Frs2,3-double mutants have reduced numbers of dendritic branches and spines in DGCs. Double-mutant mice exhibit fewer excitatory synaptic inputs onto DGCs.
    Title: Neurotrophin and FGF Signaling Adapter Proteins, FRS2 and FRS3, Regulate Dentate Granule Cell Maturation and Excitatory Synaptogenesis.
  3. Analysis of a mutant Fgfr1 allele, unable to bind to the adaptor protein, Frs2/3, indicates that Sox2 maintenance can be
    Title: FGFR1-Frs2/3 signalling maintains sensory progenitors during inner ear hair cell formation.
  4. Prominent expression of Frs2beta protein in neural cells and its association with intracellular vesicles is reported.
    Title: Prominent expression of FRS2beta protein in neural cells and its association with intracellular vesicles.
  5. The results showed that the interaction of full-length FRS2beta with FGFR1 was not enhanced by activation of the receptor kinase.
    Title: Fibroblast growth factor receptor 1 (FGFR1) tyrosine phosphorylation regulates binding of FGFR substrate 2alpha (FRS2alpha) but not FRS2 to the receptor.
  6. Some essential functions of Fgfr1 are mediated by Frs-independent signaling.
    Title: Context-specific requirements for Fgfr1 signaling through Frs2 and Frs3 during mouse development.
  7. data indicate that the fibroblast growth factor receptor substrate 2 and fibroblast growth factor receptor substrate 3 adapters may have a role in thyroid carcinogenesis triggered by TRK oncogenes
    Title: The signaling adapters fibroblast growth factor receptor substrate 2 and 3 are activated by the thyroid TRK oncoproteins.
  8. ULK2, by interaction with FRS2/3 and inhibition of SynGAP, functions to negatively regulate tyrosyl phosphorylation of signaling proteins downstream of FGFR1.
    Title: UNC-51-like kinase regulation of fibroblast growth factor receptor substrate 2/3.
  9. SNT family proteins may play significant roles in cellular transformation triggered by NPM-ALK.
    Title: Identification of multiple SNT-binding sites on NPM-ALK oncoprotein and their involvement in cell transformation.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (1)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC25496

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables fibroblast growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fibroblast growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane receptor protein tyrosine kinase adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in fibroblast growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
fibroblast growth factor receptor substrate 3
Names
FGFR substrate 3
FRS2-beta
suc1-associated neurotrophic factor target 2 (FGFR signalling adaptor)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419207.1 → NP_001406136.1  fibroblast growth factor receptor substrate 3

    Status: VALIDATED

    Source sequence(s)
    AC124830, AC139214
    UniProtKB/Swiss-Prot
    Q91WJ0

  2. NM_001419208.1 → NP_001406137.1  fibroblast growth factor receptor substrate 3

    Status: VALIDATED

    Source sequence(s)
    AC124830, AC139214
    UniProtKB/Swiss-Prot
    Q91WJ0

  3. NM_144939.3 → NP_659188.1  fibroblast growth factor receptor substrate 3

    See identical proteins and their annotated locations for NP_659188.1

    Status: VALIDATED

    Source sequence(s)
    AC124830, AC139214
    Consensus CDS
    CCDS28854.1
    UniProtKB/Swiss-Prot
    Q91WJ0
    Related
    ENSMUSP00000108921.2, ENSMUST00000113296.8
    Conserved Domains (1) summary
    cd01202
    Location:15 → 106
    PTB_FRS2; Fibroblast growth factor receptor substrate 2 phosphotyrosine-binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    47998532..48015211
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523469.4 → XP_006523532.1  fibroblast growth factor receptor substrate 3 isoform X1

    See identical proteins and their annotated locations for XP_006523532.1

    UniProtKB/Swiss-Prot
    Q91WJ0
    Conserved Domains (1) summary
    cd01202
    Location:15 → 106
    PTB_FRS2; Fibroblast growth factor receptor substrate 2 phosphotyrosine-binding domain

  2. XM_036160258.1 → XP_036016151.1  fibroblast growth factor receptor substrate 3 isoform X2

    Conserved Domains (1) summary
    cl17171
    Location:17 → 38
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91WJ0.3 GenPept UniProtKB/Swiss-Prot:Q91WJ0

Gene LinkOut

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