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Frs3 fibroblast growth factor receptor substrate 3 [ Mus musculus (house mouse) ]

Gene ID: 107971, updated on 21-Apr-2024

Summary

Official Symbol
Frs3provided by MGI
Official Full Name
fibroblast growth factor receptor substrate 3provided by MGI
Primary source
MGI:MGI:2135965
See related
Ensembl:ENSMUSG00000023266 AllianceGenome:MGI:2135965
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Snt2; Frs2beta; 4930417B13Rik
Summary
Predicted to enable fibroblast growth factor receptor binding activity; identical protein binding activity; and transmembrane receptor protein tyrosine kinase adaptor activity. Predicted to be involved in fibroblast growth factor receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; gut; immune system; lung; and metanephros. Orthologous to human FRS3 (fibroblast growth factor receptor substrate 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 16.9), CNS E18 (RPKM 9.5) and 28 other tissues See more
Orthologs
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Genomic context

Location:
17 C; 17 23.88 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (47998532..48015211)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (47687607..47704286)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene 20517 Neighboring gene mediator complex subunit 20 Neighboring gene Kpna2 retrotransposed pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10959 Neighboring gene ubiquitin specific peptidase 49 Neighboring gene STARR-positive B cell enhancer ABC_E4218 Neighboring gene prickle planar cell polarity protein 4 Neighboring gene translocase of outer mitochondrial membrane 6, opposite strand Neighboring gene translocase of outer mitochondrial membrane 6 Neighboring gene STARR-seq mESC enhancer starr_42721 Neighboring gene fibroblast growth factor receptor substrate 3, opposite strand Neighboring gene STARR-seq mESC enhancer starr_42724 Neighboring gene predicted gene, 46579 Neighboring gene progastricsin (pepsinogen C)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC25496

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables fibroblast growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables fibroblast growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane receptor protein tyrosine kinase adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in fibroblast growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
fibroblast growth factor receptor substrate 3
Names
FGFR substrate 3
FRS2-beta
suc1-associated neurotrophic factor target 2 (FGFR signalling adaptor)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419207.1NP_001406136.1  fibroblast growth factor receptor substrate 3

    Status: VALIDATED

    Source sequence(s)
    AC124830, AC139214
    UniProtKB/Swiss-Prot
    Q91WJ0
  2. NM_001419208.1NP_001406137.1  fibroblast growth factor receptor substrate 3

    Status: VALIDATED

    Source sequence(s)
    AC124830, AC139214
    UniProtKB/Swiss-Prot
    Q91WJ0
  3. NM_144939.3NP_659188.1  fibroblast growth factor receptor substrate 3

    See identical proteins and their annotated locations for NP_659188.1

    Status: VALIDATED

    Source sequence(s)
    AC124830, AC139214
    Consensus CDS
    CCDS28854.1
    UniProtKB/Swiss-Prot
    Q91WJ0
    Related
    ENSMUSP00000108921.2, ENSMUST00000113296.8
    Conserved Domains (1) summary
    cd01202
    Location:15106
    PTB_FRS2; Fibroblast growth factor receptor substrate 2 phosphotyrosine-binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    47998532..48015211
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523469.4XP_006523532.1  fibroblast growth factor receptor substrate 3 isoform X1

    See identical proteins and their annotated locations for XP_006523532.1

    UniProtKB/Swiss-Prot
    Q91WJ0
    Conserved Domains (1) summary
    cd01202
    Location:15106
    PTB_FRS2; Fibroblast growth factor receptor substrate 2 phosphotyrosine-binding domain
  2. XM_036160258.1XP_036016151.1  fibroblast growth factor receptor substrate 3 isoform X2

    Conserved Domains (1) summary
    cl17171
    Location:1738
    PH-like; Pleckstrin homology-like domain