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NOXA1 NADPH oxidase activator 1 [ Homo sapiens (human) ]

Gene ID: 10811, updated on 24-Nov-2020

Summary

Official Symbol
NOXA1provided by HGNC
Official Full Name
NADPH oxidase activator 1provided by HGNC
Primary source
HGNC:HGNC:10668
See related
Ensembl:ENSG00000188747 MIM:611255
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p51NOX; NY-CO-31; SDCCAG31
Summary
This gene encodes a protein which activates NADPH oxidases, enzymes which catalyze a reaction generating reactive oxygen species. The encoded protein contains four N-terminal tetratricopeptide domains and a C-terminal Src homology 3 domain. Interaction between the encoded protein and proteins in the oxidase regulatory complex occur via the tetratricopeptide domains. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Expression
Ubiquitous expression in duodenum (RPKM 4.2), stomach (RPKM 4.0) and 25 other tissues See more
Orthologs

Genomic context

See NOXA1 in Genome Data Viewer
Location:
9q34.3
Exon count:
15
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (137423372..137434406)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (140317847..140328858)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene NOTCH regulated ankyrin repeat protein Neighboring gene exonuclease 3'-5' domain containing 3 Neighboring gene ectonucleoside triphosphate diphosphohydrolase 8 Neighboring gene microRNA 7114 Neighboring gene NMDA receptor synaptonuclear signaling and neuronal migration factor Neighboring gene patatin like phospholipase domain containing 7 Neighboring gene 9q34.3 PNPLA7 recombination region

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • FLJ25475, MGC131800

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SH3 domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
small GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
superoxide-generating NADPH oxidase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
superoxide-generating NADPH oxidase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
superoxide-generating NADPH oxidase activator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
positive regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
regulation of hydrogen peroxide metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of respiratory burst IMP
Inferred from Mutant Phenotype
more info
PubMed 
superoxide anion generation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
superoxide metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
NADPH oxidase complex IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
NADPH oxidase activator 1
Names
NCF2-like protein
Nox activator 1
antigen NY-CO-31
inhibitory NADPH oxidase activator 1
p51-nox
p67phox-like factor
serologically defined colon cancer antigen 31

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256067.2NP_001242996.1  NADPH oxidase activator 1 isoform 2

    See identical proteins and their annotated locations for NP_001242996.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1.
    Source sequence(s)
    AB095031, BX322799
    UniProtKB/Swiss-Prot
    Q86UR1
    Conserved Domains (4) summary
    cd06411
    Location:316393
    PB1_p51; The PB1 domain is present in the p51 protein, a homolog of the p67 protein. p51 plays an important role in NADPH oxidase activation during phagosytosis. The PB1 domain is a modular domain mediating specific protein-protein interaction in many critical ...
    cd12047
    Location:403455
    SH3_Noxa1_C; C-terminal Src Homology 3 domain of NADPH oxidase activator 1
    sd00006
    Location:3866
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:38100
    TPR_11; TPR repeat
  2. NM_001256068.2NP_001242997.1  NADPH oxidase activator 1 isoform 3

    See identical proteins and their annotated locations for NP_001242997.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons in the 3' coding region compared to variant 1. The resulting protein (isoform 3) is shorter compared to isoform 1.
    Source sequence(s)
    AI860821, AY927791, BX322799
    Consensus CDS
    CCDS59157.1
    UniProtKB/Swiss-Prot
    Q86UR1
    Related
    ENSP00000376562.2, ENST00000392815.2
    Conserved Domains (4) summary
    cd06411
    Location:260337
    PB1_p51; The PB1 domain is present in the p51 protein, a homolog of the p67 protein. p51 plays an important role in NADPH oxidase activation during phagosytosis. The PB1 domain is a modular domain mediating specific protein-protein interaction in many critical ...
    sd00006
    Location:3866
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:38100
    TPR_11; TPR repeat
    cl17036
    Location:347406
    SH3; Src Homology 3 domain superfamily
  3. NM_006647.2NP_006638.1  NADPH oxidase activator 1 isoform 1

    See identical proteins and their annotated locations for NP_006638.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1).
    Source sequence(s)
    BC041594, BX322799
    Consensus CDS
    CCDS7042.1
    UniProtKB/Swiss-Prot
    Q86UR1
    Related
    ENSP00000342848.2, ENST00000341349.6
    Conserved Domains (4) summary
    cd06411
    Location:316393
    PB1_p51; The PB1 domain is present in the p51 protein, a homolog of the p67 protein. p51 plays an important role in NADPH oxidase activation during phagosytosis. The PB1 domain is a modular domain mediating specific protein-protein interaction in many critical ...
    COG0457
    Location:10118
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:3866
    TPR; TPR repeat [structural motif]
    cl17036
    Location:403462
    SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    137423372..137434406
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011518158.3XP_011516460.1  NADPH oxidase activator 1 isoform X1

    Conserved Domains (4) summary
    cd06411
    Location:280357
    PB1_p51; The PB1 domain is present in the p51 protein, a homolog of the p67 protein. p51 plays an important role in NADPH oxidase activation during phagosytosis. The PB1 domain is a modular domain mediating specific protein-protein interaction in many critical ...
    sd00006
    Location:3866
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:38100
    TPR_11; TPR repeat
    cl17036
    Location:367426
    SH3; Src Homology 3 domain superfamily
  2. XM_024447388.1XP_024303156.1  NADPH oxidase activator 1 isoform X3

    Conserved Domains (2) summary
    cd06411
    Location:168245
    PB1_p51; The PB1 domain is present in the p51 protein, a homolog of the p67 protein. p51 plays an important role in NADPH oxidase activation during phagosytosis. The PB1 domain is a modular domain mediating specific protein-protein interaction in many critical ...
    cd12047
    Location:255307
    SH3_Noxa1_C; C-terminal Src Homology 3 domain of NADPH oxidase activator 1
  3. XM_011518160.1XP_011516462.1  NADPH oxidase activator 1 isoform X2

    See identical proteins and their annotated locations for XP_011516462.1

    Conserved Domains (2) summary
    cd06411
    Location:168245
    PB1_p51; The PB1 domain is present in the p51 protein, a homolog of the p67 protein. p51 plays an important role in NADPH oxidase activation during phagosytosis. The PB1 domain is a modular domain mediating specific protein-protein interaction in many critical ...
    cl17036
    Location:255314
    SH3; Src Homology 3 domain superfamily
  4. XM_011518159.1XP_011516461.1  NADPH oxidase activator 1 isoform X2

    See identical proteins and their annotated locations for XP_011516461.1

    Conserved Domains (2) summary
    cd06411
    Location:168245
    PB1_p51; The PB1 domain is present in the p51 protein, a homolog of the p67 protein. p51 plays an important role in NADPH oxidase activation during phagosytosis. The PB1 domain is a modular domain mediating specific protein-protein interaction in many critical ...
    cl17036
    Location:255314
    SH3; Src Homology 3 domain superfamily
  5. XM_017014220.1XP_016869709.1  NADPH oxidase activator 1 isoform X2

    Conserved Domains (2) summary
    cd06411
    Location:168245
    PB1_p51; The PB1 domain is present in the p51 protein, a homolog of the p67 protein. p51 plays an important role in NADPH oxidase activation during phagosytosis. The PB1 domain is a modular domain mediating specific protein-protein interaction in many critical ...
    cl17036
    Location:255314
    SH3; Src Homology 3 domain superfamily

RNA

  1. XR_001746169.1 RNA Sequence

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