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NOXA1 NADPH oxidase activator 1 [ Homo sapiens (human) ]

Gene ID: 10811, updated on 29-Mar-2023

Summary

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Official Symbol
NOXA1provided by HGNC
Official Full Name
NADPH oxidase activator 1provided by HGNC
Primary source
HGNC:HGNC:10668
See related
Ensembl:ENSG00000188747 MIM:611255; AllianceGenome:HGNC:10668
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p51NOX; NY-CO-31; SDCCAG31
Summary
This gene encodes a protein which activates NADPH oxidases, enzymes which catalyze a reaction generating reactive oxygen species. The encoded protein contains four N-terminal tetratricopeptide domains and a C-terminal Src homology 3 domain. Interaction between the encoded protein and proteins in the oxidase regulatory complex occur via the tetratricopeptide domains. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Expression
Ubiquitous expression in duodenum (RPKM 4.2), stomach (RPKM 4.0) and 25 other tissues See more
Orthologs
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Genomic context

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See NOXA1 in Genome Data Viewer
Location:
9q34.3
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (137423393..137434406)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (149674014..149685028)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (140317845..140328858)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene exonuclease 3'-5' domain containing 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:140311837-140312663 Neighboring gene uncharacterized LOC124902354 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:140323354-140324108 Neighboring gene Sharpr-MPRA regulatory region 12030 Neighboring gene ectonucleoside triphosphate diphosphohydrolase 8 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr9:140343721-140344920 Neighboring gene microRNA 7114 Neighboring gene NMDA receptor synaptonuclear signaling and neuronal migration factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The Novel Histone Deacetylase Inhibitor, OBP-801, Induces Apoptosis in Rhabdoid Tumors by Releasing the Silencing of NOXA. Sugimoto Y, et al. Mol Cancer Ther, 2020 Oct. PMID 32847975
  2. Destabilization of NOXA mRNA as a common resistance mechanism to targeted therapies. Montero J, et al. Nat Commun, 2019 Nov 14. PMID 31727958, Free PMC Article
  3. Selective recapitulation of conserved and nonconserved regions of putative NOXA1 protein activation domain confers isoform-specific inhibition of Nox1 oxidase and attenuation of endothelial cell migration. Ranayhossaini DJ, et al. J Biol Chem, 2013 Dec 20. PMID 24187133, Free PMC Article
  4. Noxa1 as a moderate activator of Nox2-based NADPH oxidase. Kawano M, et al. Arch Biochem Biophys, 2012 Mar 1. PMID 22244833
  5. Phosphorylation of serine282 in NADPH oxidase activator 1 by Erk desensitizes EGF-induced ROS generation. Oh H, et al. Biochem Biophys Res Commun, 2010 Apr 9. PMID 20230789

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MARCH5 requires MTCH2 to coordinate proteasomal turnover of the MCL1:NOXA complex.
    Title: MARCH5 requires MTCH2 to coordinate proteasomal turnover of the MCL1:NOXA complex.
  2. MARCH5-dependent degradation of MCL1/NOXA complexes defines susceptibility to antimitotic drug treatment.
    Title: MARCH5-dependent degradation of MCL1/NOXA complexes defines susceptibility to antimitotic drug treatment.
  3. The Novel Histone Deacetylase Inhibitor, OBP-801, Induces Apoptosis in Rhabdoid Tumors by Releasing the Silencing of NOXA.
    Title: The Novel Histone Deacetylase Inhibitor, OBP-801, Induces Apoptosis in Rhabdoid Tumors by Releasing the Silencing of NOXA.
  4. mitochondrial targeting domain peptide induces necrotic cell death by interaction with the VDAC2 protein.
    Title: Noxa mitochondrial targeting domain induces necrosis via VDAC2 and mitochondrial catastrophe.
  5. These results identify NOXA mRNA destabilization/MCL-1 adaptation as a non-genomic mechanism that limits apoptotic responses.
    Title: Destabilization of NOXA mRNA as a common resistance mechanism to targeted therapies.
  6. both caspase-8-dependent and -independent apoptotic mechanisms are activated in triple-negative breast cancer cells undergoing sustained endoplasmic reticulum stress.
    Title: Involvement of both caspase-8 and Noxa-activated pathways in endoplasmic reticulum stress-induced apoptosis in triple-negative breast tumor cells.
  7. Data from pull-down assay between the Noxo1 and Noxa1 showed that the SH3 domains (Noxa1) is responsible for interaction with Noxo1 C-terminal tail harboring proline rich region.
    Title: C-terminal tail of NADPH oxidase organizer 1 (Noxo1) mediates interaction with NADPH oxidase activator (Noxa1) in the NOX1 complex.
  8. A NOXA1 peptide blocked NOXA1-Nox1 binding. The finding identifies a NOXA1-activating domain and an isoform-specific Nox1 inhibitor.
    Title: Selective recapitulation of conserved and nonconserved regions of putative NOXA1 protein activation domain confers isoform-specific inhibition of Nox1 oxidase and attenuation of endothelial cell migration.
  9. Phosphorylation of Thr341 allows Noxo1 to sufficiently interact with Noxa1, an interaction that participates in Nox1 activation
    Title: Phosphorylation of Noxo1 at threonine 341 regulates its interaction with Noxa1 and the superoxide-producing activity of Nox1.
  10. Noxa1 has quite different kinetic properties from p67(phox) and suggest that Noxa1 may function as a moderate activator of Nox2.
    Title: Noxa1 as a moderate activator of Nox2-based NADPH oxidase.
Submit: New GeneRIF Correction See all GeneRIFs (19)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • FLJ25475, MGC131800

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables SH3 domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables superoxide-generating NADPH oxidase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables superoxide-generating NADPH oxidase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables superoxide-generating NADPH oxidase activator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of hydrogen peroxide metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of respiratory burst IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in superoxide anion generation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in superoxide metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of NADPH oxidase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
NADPH oxidase activator 1
Names
NCF2-like protein
Nox activator 1
antigen NY-CO-31
inhibitory NADPH oxidase activator 1
p51-nox
p67phox-like factor
serologically defined colon cancer antigen 31

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256067.2 → NP_001242996.1  NADPH oxidase activator 1 isoform 2

    See identical proteins and their annotated locations for NP_001242996.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1.
    Source sequence(s)
    AB095031, BX322799
    Consensus CDS
    CCDS94544.1
    UniProtKB/Swiss-Prot
    Q86UR1, Q8IUS3
    Related
    ENSP00000507846.1, ENST00000683555.1
    Conserved Domains (4) summary
    cd06411
    Location:316 → 393
    PB1_p51; The PB1 domain is present in the p51 protein, a homolog of the p67 protein. p51 plays an important role in NADPH oxidase activation during phagosytosis. The PB1 domain is a modular domain mediating specific protein-protein interaction in many critical ...
    cd12047
    Location:403 → 455
    SH3_Noxa1_C; C-terminal Src Homology 3 domain of NADPH oxidase activator 1
    sd00006
    Location:38 → 66
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:38 → 100
    TPR_11; TPR repeat

  2. NM_001256068.2 → NP_001242997.1  NADPH oxidase activator 1 isoform 3

    See identical proteins and their annotated locations for NP_001242997.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons in the 3' coding region compared to variant 1. The resulting protein (isoform 3) is shorter compared to isoform 1.
    Source sequence(s)
    AI860821, AY927791, BX322799
    Consensus CDS
    CCDS59157.1
    UniProtKB/Swiss-Prot
    Q86UR1
    Related
    ENSP00000376562.2, ENST00000392815.2
    Conserved Domains (4) summary
    cd06411
    Location:260 → 337
    PB1_p51; The PB1 domain is present in the p51 protein, a homolog of the p67 protein. p51 plays an important role in NADPH oxidase activation during phagosytosis. The PB1 domain is a modular domain mediating specific protein-protein interaction in many critical ...
    sd00006
    Location:38 → 66
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:38 → 100
    TPR_11; TPR repeat
    cl17036
    Location:347 → 406
    SH3; Src Homology 3 domain superfamily

  3. NM_006647.2 → NP_006638.1  NADPH oxidase activator 1 isoform 1

    See identical proteins and their annotated locations for NP_006638.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1).
    Source sequence(s)
    BC041594, BX322799
    Consensus CDS
    CCDS7042.1
    UniProtKB/Swiss-Prot
    Q86UR1
    Related
    ENSP00000342848.2, ENST00000341349.6
    Conserved Domains (4) summary
    cd06411
    Location:316 → 393
    PB1_p51; The PB1 domain is present in the p51 protein, a homolog of the p67 protein. p51 plays an important role in NADPH oxidase activation during phagosytosis. The PB1 domain is a modular domain mediating specific protein-protein interaction in many critical ...
    COG0457
    Location:10 → 118
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:38 → 66
    TPR; TPR repeat [structural motif]
    cl17036
    Location:403 → 462
    SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    137423393..137434406
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011518158.4 → XP_011516460.1  NADPH oxidase activator 1 isoform X1

    Conserved Domains (4) summary
    cd06411
    Location:280 → 357
    PB1_p51; The PB1 domain is present in the p51 protein, a homolog of the p67 protein. p51 plays an important role in NADPH oxidase activation during phagosytosis. The PB1 domain is a modular domain mediating specific protein-protein interaction in many critical ...
    sd00006
    Location:38 → 66
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:38 → 100
    TPR_11; TPR repeat
    cl17036
    Location:367 → 426
    SH3; Src Homology 3 domain superfamily

  2. XM_047422658.1 → XP_047278614.1  NADPH oxidase activator 1 isoform X2

  3. XM_047422660.1 → XP_047278616.1  NADPH oxidase activator 1 isoform X4

  4. XM_011518159.2 → XP_011516461.1  NADPH oxidase activator 1 isoform X3

    See identical proteins and their annotated locations for XP_011516461.1

    Conserved Domains (2) summary
    cd06411
    Location:168 → 245
    PB1_p51; The PB1 domain is present in the p51 protein, a homolog of the p67 protein. p51 plays an important role in NADPH oxidase activation during phagosytosis. The PB1 domain is a modular domain mediating specific protein-protein interaction in many critical ...
    cl17036
    Location:255 → 314
    SH3; Src Homology 3 domain superfamily

  5. XM_047422659.1 → XP_047278615.1  NADPH oxidase activator 1 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    149674014..149685028
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054361808.1 → XP_054217783.1  NADPH oxidase activator 1 isoform X1

  2. XM_054361809.1 → XP_054217784.1  NADPH oxidase activator 1 isoform X2

  3. XM_054361813.1 → XP_054217788.1  NADPH oxidase activator 1 isoform X4

  4. XM_054361810.1 → XP_054217785.1  NADPH oxidase activator 1 isoform X3

  5. XM_054361811.1 → XP_054217786.1  NADPH oxidase activator 1 isoform X3

  6. XM_054361812.1 → XP_054217787.1  NADPH oxidase activator 1 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86UR1.1 GenPept UniProtKB/Swiss-Prot:Q86UR1

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